Art

J-GLOBAL ID：201002208507947258   Reference number：10A0272257

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

選択的オートファジー基質p62はKeap1不活化を介してストレス応答転写因子Nrf2を活性化する

Author (22)： KOMATSU Masaaki (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  KOMATSU Masaaki (JST-PRESTO, Kawaguchi, JPN) ,  KUROKAWA Hirofumi ,  WAGURI Satoshi (Fukushima Medical Univ. School of Medicine, Fukushima, JPN) ,  TAGUCHI Keiko ,  KOBAYASHI Akira (Doshisha Univ., Kyoto, JPN) ,  ICHIMURA Yoshinobu (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  ICHIMURA Yoshinobu (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  SOU Yu-Shin (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  SOU Yu-Shin (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  UENO Izumi (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  SAKAMOTO Ayako (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  TONG Kit I. ,  KIM Mihee (Doshisha Univ., Kyoto, JPN) ,  NISHITO Yasumasa (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  IEMURA Shun-ichiro (National Inst. Advanced Industrial Sci. and Technol., Tokyo, JPN) ,  NATSUME Tohru (National Inst. Advanced Industrial Sci. and Technol., Tokyo, JPN) ,  UENO Takashi (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  KOMINAMI Eiki (Juntendo Univ. School of Medicine, Tokyo, JPN) ,  MOTOHASHI Hozumi ,  TANAKA Keiji (Tokyo Metropolitan Inst. Medical Sci., Tokyo, JPN) ,  YAMAMOTO Masayuki
Material： Nature Cell Biology  (Nat Cell Biol)
Volume： 12  Issue： 3  Page： 213-223  Publication year： Mar. 2010 
JST Material Number： W1369A  ISSN： 1465-7392  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *phagocytosis ,  *protein ,  actin binding protein ,  metalloprotein ,  DNA binding protein ,  transcription factor ,  binding site ,  protein complex ,  transcription(genetics) ,  genetic regulation ,  crystal structure ,  hydrogen bond ,  mouse(animal) ,  hepatic dysfunction ,  intermolecular interaction ,  activation ,  *autophagy
Semi thesaurus term： Keap1 protein ,  Nrf2 protein ,  *p62 ,  protein interaction ,  Transcriptional Activation

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (9)： 選択的オートファジー ,  基質 ,  p62 ,  Keap1 ,  不活化 ,  ストレス応答 ,  転写因子 ,  NRF2 ,  活性化