- 2021 - 2024 Investigating mechanisms of axial elongation control by non-visual opsin
- 2020 - 2023 Development and clinical application of drugs for prevention and treatment of dry eye
- 2017 - 2020 A novel prevention and treatment method of ocular aging by targeting sirtuins.
- 2016 - 2019 Effect of a Sema3A inhibitor treatment in a murine dry eye model
- 2014 - 2017 A significant role of senescent cells and donor mesenchymal stem cells in ocular chronic graft-versus-host disease and development of new therapy
- 2014 - 2017 The association of retinal thickness measurements with cognitive impairment in a Japanese population
- 2014 - 2016 Metabolite profiles and age-related macular degeneration
- 2013 - 2016 Elucidation of the mechanism to control tear secretion by anti-aging approach
- 2013 - 2016 Development of technologies for next-generation regenerative therapies
- 2013 - 2015 The energy metabolism and tear secretion
- 2011 - 2013 Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.
- 2010 - 2012 Evaluation of mechanisms by which caloric restriction regulates mitochondrial function
- 2010 - 2012 Molecular mechanism of dry eye disease
- 2010 - 2011 Molecular mechanism of gender gap in dry eye disease
- 2009 - 2010 A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice
- 2008 - 2010 Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention
- 2008 - 2009 IP3受容体およびムスカリニック受容体欠損マウスを用いた涙液分泌機構
- 2007 - 2008 The mechanism of peripheral nerve regeneration following corneal transplantation on mice
- 2007 - 2008 The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitis
- 2005 - 2007 Pathophysiology of conjunctival goblet cells
- 2005 - 2006 DEVELOPMENT OF CULTURE METHODS FOR EXOCRINE GLAND STEM CELLS USING GENE-TRANSDUCED FEEDER CELLS AND THEIR APPLICATION FOR TREATMENT
- 2005 - 2006 Searching the tissue specific autoimmune disease related gene by linkage analysis and establishment of a diagnosis method
- 2004 - 2005 The mechanism of exocrine gland disorder through estrogen and/or endocrine disruptors
- 2003 - 2004 Expression of the fetal HLA-G molecule by ocular surface epithelium is enhanced when expanded on amniotic membranes
- 2001 - 2004 涙液産生におけるアクアポリン5の生理的役割の解明
- 2002 - 2003 Identification of animal model for autoimmune disease using conditional expression of transgene
- 2001 - 2001 シェーグレン症候群診断基準査定調査の企画
- 2000 - 2001 Enhanced lacrimation and salivation in prolactin transgenic rats
- 1998 - 1999 A study on adhesion and retainment of saliva on the oral surface in the patient with xerostomia and Sjogren's syndrome
- 1998 - 1999 An organ-specific autoantigen for Sjogren's syndrome induced by Epstein-Barr virus activation
- 1997 - 1998 眼温度測定と気化熱解析による生体の水濡れ性測定機
- 1996 - 1998 Lacrimal gland transplantation for improvement of the gland function
- 1996 - 1997 Establishment of in vitro model for the Epstein-Barr virus reactivation in Sjogren's syndrome
- 1996 - 1997 Immunohistological analysis of TGF-beta1 expression in salivary glands
- 1995 - 1997 Detection of possible factors for the Epstein-Barr virus reactivation in Sjogren's syndrome
- 1995 - 1996 HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION
- 1994 - 1995 Analysis of temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.
- 1993 - 1994 HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION
- 1992 - 1993 眼乾燥症(ドライアイ)の病因論に関する免疫学的、分子生物学的研究
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