Shibata Takehiko

シバタタケヒコ | Shibata Takehiko

Affiliation and department：
Job title： Unit Lieder
Other affiliations (1)：

特定国立研究開発法人理化学研究所名誉研究員

Homepage URL (1)： http://www.riken.go.jp/r-world/research/lab/wako/shibata/index.html

Research field (5)： Evolutionary biology , Molecular biology , Functional biochemistry , Structural biochemistry , Genetics

Research keywords (19)： Nonhomologous end-joining , mitochonrial genetics , mitochondrial genetics , mitochondrial DNA , メンデル遺伝 , molecular structure , DNA , molecular evolution , protein function , Rad51 , RecA , 相同組換え , recombination enzyme , Genetic recombination , 3D structure of Proteins DNA , Evolution , RecA/Rad51 proteins , DNA recombination , Homologous Genetic Recombination

Research theme for competitive and other funds (6)：

2010 - 相同組換え開始とその制御の機構についての遺伝学、生化学、構造生物学
2004 - 相同DNA組換え制御技術・標的組換え技術の実現
相同DNA組換えのミトコンドリアでの機能を明らかにする
The developments of new genome technology using controlled homologous recombination
Biochemical and structural biological studies on the regulation of partner selection and consequence of homologous recombination.

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Papers (97)：

Shinohara, T, Arai, N, Iikura, Y, Kasagi, M, Masuda-Ozawa, T, Yamaguchi, Y, Suzuki-Nagata, K, Shibata, T, Mikawa, T. Nonfilament-forming RecA dimer catalyzes homologous joint formation. Nonfilament-forming RecA dimer catalyzes homologous joint formation. 2018. Online
Muramoto, N, Oda, A, Tanaka, H, Nakamura, T, Kugou, K, Suda, K, Kobayashi, A, Yoneda, S, Ikeuchi, A, Sugimoto, H, et al. Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks. Nature Communications. 2018. 9. 1995
Naoto Konomura, Naoto Arai, Takeshi Shinohara, Jun Kobayashi, Wakana Iwasaki, Shukuko Ikawa, Kohji Kusano, Takehiko Shibata. Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions. NUCLEIC ACIDS RESEARCH. 2017. 45. 1. 337-352
Feng Ling, Rong Niu, Hideyuki Hatakeyama, Yu-ichi Goto, Takehiko Shibata, Minoru Yoshida. Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells. MOLECULAR BIOLOGY OF THE CELL. 2016. 27. 10. 1684-1693
Takeshi Shinohara, Shukuko Ikawa, Wakana Iwasaki, Toshiki Hiraki, Takaaki Hikima, Tsutomu Mikawa, Naoto Arai, Nobuo Kamiya, Takehiko Shibata. Loop L1 governs the DNA-binding specificity and order for RecA-catalyzed reactions in homologous recombination and DNA repair. NUCLEIC ACIDS RESEARCH. 2015. 43. 2. 973-986

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MISC (10)：

H Kurumizaka, S Ikawa, M Nakada, R Enomoto, W Kagawa, T Kinebuchi, M Yamazoe, S Yokoyama, T Shibata. Homologous pairing and ring and filament structure formation activities of the human Xrcc2-Rad51D complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. 277. 16. 14315-14320
Counteracting regulation of chromatin remodeling at a fission yeast CRE-related recombination hotspot by SAPK, cAMP-dependent kinase, and meiosis regulators. Genetics. 2001. 159, 1467-1478
H. Senbongi, F. Ling, T. Shibata. A mutation in a mitochondrial ABC transporter results in mitochondrial dysfunction through oxidative damage of mitochondrial DNA. Molecular and General Genetics. 1999. 262. 3. 426-436
DNAはどのようにして相同部位を認識し、鎖を交換するか?-相同検索、鎖交換反応のDNA分子構造模型-. 蛋白質核酸酵素, 44, 631-342 (1999)
細胞エネルギー供給の知られざる裏方:ミトコンドリアゲノムの安定性を支配するDNA組換え. 化学と生物, 34, 643-651 (1996)

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Patents (17)：

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Education (4)：

The University of Tokyo Faculty of Science
東京大学理学系研究科
University of Tokyo, School of Science
University of Tokyo, Graduate School of Science

Professional career (1)：

Ph. D.

Work history (19)：

2013 - 現在 Yokohama City University
2005 - 現在理化学研究所名誉研究員
2014 - 2015 理化学研究所環境資源科学研究センター先進機能触媒研究グループ嘱託職員
2015 - 現職
2010 - 2014 RIKEN

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Awards (1)：

1983 農芸化学奨励賞

Association Membership(s) (9)：

ェ , 日本農芸化学会 , 日本蛋白質科学会 , 日本分子生物学会 , 日本生化学会 , 日本遺伝学会 , The Molecular Biology Society of Japan , The Japanese Biochemical Society , The Genetic Society of Japan

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