Research theme for competitive and other funds (10):
2015 - 2019 Preparation of species-selective MetAP inhibitors activated by peptide deformylase
2014 - 2017 Identification of biological activities mediated by GPCR in dynamic equilibrium state of monomer and dimer
2011 - 2013 Discrimination of Biological Signals from Dimeric Heteroreceptors
2008 - 2010 Synthesis of Transmembrane Peptides Discriminate Multiple Biological activities from Heterodetic Dimeric Receptors
2007 - 2008 Elucidation of recognition mechanism on N-terminal methionine residue by means of mimetic probe molecules and application to biological defense
2006 - 2007 Development of Neutrophile Regulatory Peptides with Receptor Association Structures
2004 - 2005 Functional Structure Analysis of Ion-channel Oligomer and Production of regulating Peptides.
含フッ素アミノ酸の合成と生理活性ペプチドへの導入
Synthesis of unnatural amino acids.
Synthesis of fluorine-containing amino acids and their peptides
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Papers (113):
Taiki Nakatani, Ami Koga, Shogo Goto, Marina Inoue, Keita Shigedomi, Kiyohiko Seki, Kaoru Araki, Junichi Taira, Hiroaki Kodama, Satoshi Osada. Importance of isoleucine residue in ion channel formation ability of 11-residue peptaibols. Bioorganic and Medicinal Chemistry. 2024. 110
Takashi Matsumura, Masaya Ono, Satoshi Osada, Fumikazu Matsuhisa, Masanori Ochiai, Yoichi Hayakawa. N-acetyloxfenicine strongly induces mitohormesis in mice as well as in insects. FEBS Letters. 2023. 597. 2. 288-297
Dan Yu, Shintaro Morisada, Hidetaka Kawakita, Koichi Sakaguchi, Satoshi Osada, Keisuke Ohto, Katsutoshi Inoue, Xi Ming Song, Guolin Zhang, Ramachandra Rao Sathuluri. Gold recovery from precious metals in acidic media by using human hair waste as a new pretreatment-free green material. Journal of Environmental Chemical Engineering. 2021. 9. 1
Motomichi Fujita, Manabu Sasada, Takuya Iyoda, Reo Nagai, Chikako Kudo, Tetsuya Yamamoto, Satoshi Osada, Hiroaki Kodama, Fumio Fukai. Anoikis resistance conferred by tenascin-C-derived peptide TNIIIA2 and its disruption by integrin inactivation. Biochemical and Biophysical Research Communications. 2021. 536. 14-19
Keita Shigedomi, Satoshi Osada, Masoud Jelokhani-Niaraki, Hiroaki Kodama. Systematic Design and Validation of Ion Channel Stabilization of Amphipathic α-Helical Peptides Incorporating Tryptophan Residues. ACS Omega. 2021. 6. 1. 723-732