Research field (3):
Cell biology
, Molecular biology
, Genetics
Research keywords (2):
mRNA品質管理機構における翻訳抑制とタンパク質分解の普遍的役割の解析
, General roles of translation repression and protein degradation by the proteasome in mRNA surveillance system in eukaryotes.
Research theme for competitive and other funds (25):
2021 - 2026 Management of non-domain biopolymer research group
2021 - 2026 Analysis of non-domain type RNA sequences in the mRNA untranslated region
2022 - 2025 異常翻訳の感知応答と解消システムの分子機構の解明
2019 - 2021 Molecular basis for regulation of RQC by specific ribosome ubiquitination
2018 - 2021 Dynamism of codon-mediated regulation of gene expression
2015 - 2020 International Activities Supporting Group for Nascent Chain Biology
2014 - 2019 Nascent-Chain Biology
2014 - 2019 Analysis of novel functions of nascent-chain in quality controls of mRNA and protein
2014 - 2017 Analysis of protein degradation promoting mechanism derived from abnormal mRNA
2013 - 2015 mRNA品質管理機構におけるユビキチン化の新規機能の解析
2008 - 2014 Comprehensive promotion of research on RNA program
2008 - 2013 Diversity and asymmetry achieved by RNA program
2008 - 2008 UAAナンセンス変異におけるリードスルー効率の評価系の構築
2008 - 2008 プロテアソームによるナンセンス変異依存タンパク質分解機構の解析
2005 - 2008 機能性RNAによる代謝調節の分子基盤の解析
2005 - 2006 mRNA分解と翻訳抑制による異常タンパク質の合成抑制機構の解析
2002 - 2006 Messenger RNA regulation by 5'-cap structure
2004 - 2005 Analysis of trans-translation by isolation of ribosome mutants
2001 - 2003 Signal transduci ion and control of gene expression regarding glucose metabolism in Escherichia coli
2002 - 2002 膜内在性タンパク質IICBGlcにおける膜輸送と発現制御の解析
2001 - 2001 TmRNA系による標的タンパク質の精製と同定の試み
2001 - mRNA品質管理機構と翻訳制御
2001 - mRNA quality control and translation regulation
1997 - 1998 大腸菌グルコース効果の分子機構とcAMPの新しい役割
1997 - 1997 10SaRNAによるTrans-Translationの分子機構の解析
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Papers (89):
Toshifumi Inada, Roland Beckmann. Mechanisms of Translation-coupled Quality Control. Journal of molecular biology. 2024. 436. 6. 168496-168496
Masaaki Komatsu, Toshifumi Inada, Nobuo N Noda. The UFM1 system: Working principles, cellular functions, and pathophysiology. Molecular cell. 2024. 84. 1. 156-169
Ryosuke Ishimura, Sota Ito, Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, Nobuo N. Noda, Masaaki Komatsu. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Science Advances. 2023. 9. 33
Kota Ishibashi, Yuichi Shichino, Peixun Han, Kimi Wakabayashi, Toshifumi Inada, Seisuke Kimura, Shintaro Iwasaki, Yuichiro Mishima. Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in vertebrates. 2023
Kota Ishibashi, Yuichi Shichino, Peixun Han, Toshifumi Inada, Seisuke Kimura, Shintaro Iwasaki, Yuichiro Mishima. No-go decay dampens zinc finger protein mRNAs in vertebrates. 2023
Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast
2007 - 2009