Obata Tohru

オバタトオル | Obata Tohru

Affiliation and department：

Research field (4)： Clinical pharmacy , Pharmaceuticals - health and biochemistry , Cell biology , Pharmaceuticals - chemistry and drug development

Research keywords (3)：癌化学療法学 , 癌化学療法 , Cancer Chemotherapy

Research theme for competitive and other funds (5)：

2021 - 2024 酸化還元電位を新指標とした光不安定医薬品のテーラーメード製剤化
2019 - 2023 銅触媒下で行なうタンデム反応を利用したセレン含有誘導体の一般合成法の開発
2003 - 2004 ヌクレオシドトランスポーターと抗腫瘍性ヌクレオシドに対する感受性との関連性
新規抗腫瘍性ヌクレオシドの作用機構の解明
Antitumor mechanisms of novel nucleosides

Papers (26)：

TOHRU OBATA, SARA SHIRATANI, TOMOMI NADA, YAYOI KASAYA, MITSUHIRO ARISAWA, SATOSHI SHUTO, MOTOHIRO TANAKA. Structure-activity Relationship of Indomethacin Derivatives as IDO1 Inhibitors. Anticancer Research. 2021. 41. 5. 2287-2296
Mio Matsumura, Tsutomu Takahashi, Hikari Yamauchi, Shunsuke Sakuma, Yukako Hayashi, Tadashi Hyodo, Tohru Obata, Kentaro Yamaguchi, Yasuyuki Fujiwara, Shuji Yasuike. Synthesis and anticancer activity of bis(2-arylimidazo[1,2-a]pyridin-3-yl) selenides and diselenides: the copper-catalyzed tandem C-H selenation of 2-arylimidazo[1,2-a]pyridine with selenium. Beilstein Journal of Organic Chemistry. 2020. 16. 1075-1083
Yamada, Mizuki, Takahashi, Tsutomu, Hasegawa, Mai, Matsumura, Mio, Ono, Kanna, Fujimoto, Ryota, Kitamura, Yuki, Murata, Yuki, Kakusawa, Naoki, Tanaka, Motohiro, et al. Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles. Bioorganic & Medicinal Chemistry Letters. 2018. 28. 2. 152-154
Yuki Kitamura, Mio Matsumura, Yuki Murata, Mizuki Yamada, Naoki Kakusawa, Motohiro Tanaka, Hiroyuki Okabe, Hiroshi Naka, Tohru Obata, Shuji Yasuike. A versatile synthesis of triarylantimony difluorides by fluorination of triarylstibanes with nitrosyl tetrafluoroborate and their antitumor activity. Journal of Fluorine Chemistry. 2017. 199. 1-6
Egashira, Miki, Suzuki, Takahiro, Orimoto, Ai, Obata, Tohru, Nakamura, Hiroshi, Tanaka, Motohiro, Kanamori, Takao, Kawai, Tatsushi. Structure-cytotoxicity relationship of methacrylate-based resin monomers as evaluated by an anti-oxidant responsive element-luciferase reporter assay. Dental Materials Journal. 2016. 35. 6. 946-951

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MISC (47)：

Yoshio Endo, Yoshihiro Uto, Yusei Shinohara, Chiaki Abe, Tohru Obata, Yutaka Yonemura, Shun-ichiro Ogura. An iron metabolism-targeting drug with antitumor activity enhances the effect of 5-ALA-based photodynamic therapy. CANCER SCIENCE. 2021. 112. 917-917
Yoshio Endo, Yoshihiro Uto, Yusei Shinohara, Chiaki Abe, Tohru Obata, Shun-ichiro Ogura, Yutaka Yonemura. Overcoming acquired resistance to photodynamic therapy using 5-aminolevulinic acid in gastric cancer cells. CANCER SCIENCE. 2018. 109. 594-594
Yoshio Endo, Yoshihiro Uto, Tohru Obata, Chiaki Abe, Shun-ichiro Ogura, Yutaka Yonemura. Development of novel Schiff base derivative for enhancing the anticancer potential of ALA-based photodynamic therapy. CANCER SCIENCE. 2018. 109. 373-373
Endo Yoshio, Obata T., Murata D., Ito M., Kadohira M., Sasaki T. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. Cancer Research Institute report. 2006. 2003. 118-118
M Sekine, K Okada, K Seio, H Kakeya, H Osada, T Obata, T Sasaki. Synthesis of chemically stabilized phosmidosine analogues and the structure-activity relationship of phosmidosine. JOURNAL OF ORGANIC CHEMISTRY. 2004. 69. 2. 314-326

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Books (1)：

腹膜播種
へるす出版(東京) 1996

Lectures and oral presentations (25)：

アミノレブリン酸を用いるがん光線力学的療法に対する新規シッフ塩基誘導体の感受性増強作用
(日本薬学会第139年会 2020)
新規シッフ塩基による5-アミノレブリン酸を用いるがん光線力学的療法の効果増強作用
(第78回日本癌学会学術総会 2019)
Mechanisms and overcome of acquired resistance to photodyn amic therapy using 5-aminolevulinic acid in cancer cells
(2019)
5-アミノレブリン酸を用いる光線力学的療法に対して耐性化した胃がん細胞における感受性回復に関する研究
(第77回日本癌学会学術総会 2018)
インドメタシン誘導体のIDO阻害活性
(日本薬学会第138年会 2018)

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Education (4)：

- 1998 Kanazawa University
1992 - 1994 Kanazawa University Graduate School, Division of Medicine
1988 - 1992 Hokuriku University Faculty of Pharmaceutical Science Department of Pharmacy
- 1992 Hokuriku University Faculty of Pharmaceutical Science

Professional career (2)：

(BLANK) (Kanazawa University)
(BLANK) (Kanazawa University)

Work history (14)：

2015/04/01 - 現在愛知学院大学大学院薬学研究科医療薬学専攻准教授
2015/04/01 - 現在愛知学院大学薬学部生体有機化学准教授
2012/04/01 - 2015/03/31 愛知学院大学大学院薬学研究科医療薬学専攻講師
2010/09/01 - 2015/03/31 愛知学院大学薬学部生体有機化学講師
2007/04/01 - 2010/08/31 愛知学院大学薬学部生体有機化学助教

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Awards (1)：

2017/10 - 日本色材協会色材協会論文賞

Association Membership(s) (5)：

がん分子標的治療研究会 , 日本薬学会 , 日本癌学会 , 日本分子生物学会 , がん分子標的治療学会

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