Oyamada Hideto

オヤマダヒデト | Oyamada Hideto

Affiliation and department：

Research field (1)： Pharmacology

Research theme for competitive and other funds (9)：

2019 - 2024 悪性高熱症の遺伝子診断を目指した1型リアノジン受容体遺伝子変異体の作製と発現
2016 - 2019 A trial for establishment of the cell banks as the models of malignant hyperthemia
2003 - 2006 SCREENING FOR THE FUNCTIONAL DOMAINS IN THE RYANODINE RECEPTOR
2002 - 2003 DEVELOPMENT OF THE VISUALIZED DOMINANT NEGATIVE METHOD FOR THE CALCIUM RELEASE CHANNEL
2000 - 2002 SPATIO-TEMPORAL ANALYSIS OF CA^<2+> RELEASE CHANNEL RELATED TO THE VARIOUS TYPE OF THE INTRACELLULAR CA^<2+> SIGNALS

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Papers (65)：

Takashi Murayama, Yuya Otori, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Takashi Sakurai, Haruo Ogawa. Dual role of the S5 segment in type 1 ryanodine receptor channel gating. Communications Biology. 2024. 7. 1
Kotaro Oyama, Vadim Zeeb, Toshiko Yamazawa, Takashi Murayama, Hideto Oyamada, Yoshie Harada, Norio Fukuda, Shin'ichi Ishiwata, Madoka Suzuki. Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia. 2020
Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Katsuji Oguchi, Takashi Sakurai, et al. Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics. Journal of General Physiology. 2020. 152. 1. 1-14
Yoshiko KUDO, Hideto OYAMADA, Tomoyuki MATSUOKA, Ayami INAGAKI, Hiromichi TSUCHIYA, Yoko AO, Atsushi Michael KIMURA, Mayumi TSUJI, Katsuji OGUCHI, Yuji KIUCHI. Construction of an All-in-one Double-conditional shRNA Expression Vector. The Showa University Journal of Medical Sciences. 2019. 31. 1. 41-50
OKAZAKI Keinosuke, YASUMOTO Taro, KIUCHI Yuji, SASAKI Tadanori, SASAKI Akiko, TSUNODA Yuko, FURUYA Kanji, TSUJI Mayumi, UDAKA Yuko, OYAMADA Hideto, et al. Eribulin Treatment Induces High Expression of miR-195 and Inactivates the Wnt/β - catenin Signaling Pathway in Triple-negative Breast Cancer. The Showa University Journal of Medical Sciences. 2018. 30. 3. 359-370

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MISC (78)：

木内祐二, 小山田英人, 石野敬子, 石川文博, 宇髙結子. 新型コロナウイルスと分析化学医療系大学の基礎系教員の支援により開設した"新型コロナウイルス対応PCRセンター"の活動. ぶんせき / 日本分析化学会編. 2020. 2020. 12. 485-489
Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kanemaru Kazunori, Takashi Sakurai, Masamitsu Iino. Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
Toshiko Yamazawa, Haruo Ogawa, Maki Yamaguchi, Takashi Murayama, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Takashi Sakurai, Iino Masamitsu. Investigation of Mutant Ryanodine Receptor Channel Activity using Functional Analysis and Molecular Dynamics. BIOPHYSICAL JOURNAL. 2019. 116. 3. 521A-522A
山澤徳志子, 山口眞紀, 小川治夫, 村山尚, 小山田英人, 呉林なごみ, 鈴木純二, 金丸和典, 櫻井隆, 飯野正光. 悪性高熱症関連変異を有する骨格筋型リアノジン受容体の構造と機能変化. 日本筋学会学術集会プログラム・抄録集. 2018. 4回. 167-167
村山尚, 呉林なごみ, 湯浅磨里, 石上, 森修一, 鈴木志奈, 秋間龍之介, 小川治夫, 鈴木純二, 金丸和典, et al. 小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング. 日本筋学会学術集会プログラム・抄録集. 2018. 4回. 180-180

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Lectures and oral presentations (42)：

Construction and integration of the All-in-One type single double-conditional shRNA expression vectors for spatio-temporal gene and/or cell targeting
(The 42nd Annual Meeting of the Japan Neuroscience Society 2019)
ヒト乳がん細胞株MDA-MB-231のCD44陽性細胞においてmicroRNA-17、-93はp21発現を抑制する
(日本癌学会総会記事 2017)
ヒト角膜上皮細胞における紫外線誘発細胞毒性に対する緑茶カテキンの抑制効果についての検討(学位甲)
(昭和学士会雑誌 2016)
MDA-MB-231 CD44陽性細胞はTublin阻害剤曝露後miR-93増加によりp21発現を抑制する
(日本癌学会総会記事 2016)
TNBCのBasal likeではEribulinとROS阻害剤の併用添加で酸化ストレス増加を抑制する
(日本乳癌学会総会プログラム抄録集 2015)

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Professional career (1)：

博士(医学) (東京大学医学系研究科)

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