Kinoshita Takayoshi

キノシタタカヨシ | Kinoshita Takayoshi

Affiliation and department：

Research field (3)： Pharmaceuticals - chemistry and drug development , Chemical biology , Structural biochemistry

Research keywords (3)： SBDD , X線結晶構造解析 , シグナル伝達

Research theme for competitive and other funds (7)：

2016 - 2020 Crystal structure analysis for intermediate in enzymatic reaction by using neutron beam
2015 - 2018 Structural basis for auto-inhibition mechanisms of MAP2K
2014 - 2017 A new strategy to develop therapeutic agents for neurodegenerative diseases by structural biology
2012 - 2015 The activating mechanism of the FGFR3 pathogenic mutants
2007 - 2008 Ultra-high resolution X-ray and neutron analyses aimed for producing highly selective JNK1 inhibitors

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Papers (49)：

Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi. Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water. RSC Medicinal Chemistry. 2024
Keiji Nishiwaki, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Shiori Nakatani, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi. Design, Synthesis and Structure-Activity Relationship Studies of Protein Kinase CK2 Inhibitors Containing a Purine Scaffold. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 558-565
Asaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, Masaaki Sawa, Shinya Nakamura, Isao Nakanishi, Takayoshi Kinoshita. Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2α1-selective inhibitors. Biochemical and biophysical research communications. 2022. 630. 30-35
Yuka Murakawa, Shirly Valter, Haim Barr, Nir London, Takayoshi Kinoshita. Structural basis for producing selective MAP2K7 inhibitors. Bioorganic and Medicinal Chemistry Letters. 2020. 30. 22
Masato Tsuyuguchi, Tetsuko Nakaniwa, Akira Hirasawa, Isao Nakanishi, Takayoshi Kinoshita. Structural insights for producing CK2α1-specific inhibitors. Bioorganic and Medicinal Chemistry Letters. 2020. 30. 2

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MISC (2)：

Nakanishi Shinsuke, Okada Hironori, Moriwaki Hirotomo, Nishiwaki Keiji, Nakamura Shinya, Kinoshita Takayoshi, Oishi Shinya, Ohno Hiroaki, Fujii Nobutaka, Nakanishi Isao. Binding free energy-guided design of Protein kinase CK2 inhibitors and structure-activity relationship analysis. Proceedings of the Symposium on Chemoinformatics. 2014. 2014. 0. P08-P08
Takayoshi Kinoshita, Kentaro Doi, Hajime Sugiyama, Shuhei Kinoshita, Mutsuyo Wada, Shuji Naruto, Atsushi Tomonaga. Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery. Chemical Biology and Drug Design. 2011. 78. 3. 471-476

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