Demachi-Okamura Ayako

オカムラアヤコ | Demachi-Okamura Ayako

Affiliation and department：
Homepage URL (1)： https://www.pref.aichi.jp/cancer-center/ri/01bumon/08hatsugan_seigyo/03member.html

Research field (2)： Tumor diagnostics and therapeutics , Immunology

Research keywords (3)：腫瘍免疫 , 細胞傷害性Tリンパ球 , 腫瘍抗原

Research theme for competitive and other funds (9)：

2024 - 2027 Analysis on T cells that are specific for MR1-restricted targets derived from tumors
2021 - 2023 免疫一細胞データ解析による改変型T細胞受容体デザイン技術の開発
2019 - 2022 オートファジー亢進型膵臓がんに対するがん免疫治療ターゲットの探索
2018 - 2022 Affinity maturation of cancer-specific TCRs by in vitro cell display methods and their application to drug discovery.
2016 - 2019 オートファジーによって生成されるエピトープによる抗腫瘍効果の検討

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Papers (29)：

Aiko Ogasawara, Hirokazu Matsushita, Tuan Zea Tan, Daisuke Shintani, Jieru Ye, Shoji Nagao, Ayako Demachi-Okamura, Daisuke Muraoka, Yukari Kobayashi, Kazuhiro Kakimi, et al. Immunological impact of intraperitoneal and intravenous chemotherapy in ovarian cancer, translational analyses of the Phase 3 iPocc trial. Gynecologic Oncology. 2024. 191. 124-131
Yusuke Sugita, Daisuke Muraoka, Ayako Demachi-Okamura, Hiroyasu Komuro, Katsuhiro Masago, Eiichi Sasaki, Yasunori Fukushima, Takuya Matsui, Shuichi Shinohara, Yusuke Takahashi, et al. Candidate tumor-specific CD8 ⁺ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis. OncoImmunology. 2024. 13. 1
Hiroyasu Komuro, Shuichi Shinohara, Yasunori Fukushima, Ayako Demachi-Okamura, Daisuke Muraoka, Katsuhiro Masago, Takuya Matsui, Yusuke Sugita, Yusuke Takahashi, Reina Nishida, et al. Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer. Journal for immunotherapy of cancer. 2023. 11. 8
Carolyne Barakat, Yuichiro Inagaki, Shohei Mizuno, Nobuhiro Nishio, Naoya Katsuyama, Yoshie Sato, Miki Kobayashi, Kazutaka Ozeki, Hiroatsu Iida, Akihiro Tomita, et al. Development of TCR-T cell therapy targeting mismatched HLA-DPB1 for relapsed leukemia after allogeneic transplantation. International journal of hematology. 2023. (in press). 2. 252-266
Shuichi Shinohara, Yusuke Takahashi, Hiroyasu Komuro, Takuya Matsui, Yusuke Sugita, Ayako Demachi-Okamura, Daisuke Muraoka, Hirotomo Takahara, Takeo Nakada, Noriaki Sakakura, et al. New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis. Journal for ImmunoTherapy of Cancer. 2022. 10. 4. e003765-e003765

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MISC (3)：

篠原周一, 高橋祐介, 岡村(出町) 文子, 松下博和. ネオ抗原の同定と抗原特異的免疫療法の開発. 2020. 61. 9. 1433-1439
松下博和, 岡村(出町)文子, 髙橋祐介. ネオアンチゲンはがんに対するナチュラルに誘導されるあるいは治療により誘導される免疫応答の重要な標的である. 2019. 46. 9. 1372-1376
岡村文子, 葛島清隆. 人工抗原提示細胞を用いた抗腫瘍CTLの誘導と抗原の同定. 臨床免疫・アレルギー科. 2014. 62. 6. 645-648

Patents (1)：

日本特許(特願2005-315306)「エプス

Professional career (1)：

博士(医学)

Work history (6)：

2019/04 - 現在 Aichi Cancer Center, Research Institute
2018 - 2019 Aichi Cancer Center, Research Institute
2015 - 2018 Aichi Cancer Center, Research Institute
2009 - 2015 Aichi Cancer Center, Research Institute
2007 - 2008 Aichi Cancer Center, Research Institute

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Committee career (2)：

2020 - 2021 日本学術振興会科学研究費審査委員
2016 - 2017 日本学術振興会科学研究費審査委員

Awards (1)：

2009 - 第13回日本がん免疫学会総会第1回若手研究奨励賞

Association Membership(s) (3)：

JAPANESE SOCIETY FOR IMMUNOLOGY (JSI) , 日本がん免疫学会 , THE JAPANESE CANCER ASSOCIATION

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