Rchr
J-GLOBAL ID:201001056690263933
Update date: Nov. 20, 2024
Okubo Yusuke
オオクボ ユウスケ | Okubo Yusuke
Affiliation and department:
Job title:
Chief
Other affiliations (2):
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Yokohama National University
Institute of Advanced Sciences
Visiting Associate Professor
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Kanagawa Institute of Industrial Science and Technology
Research keywords (6):
Toxicology
, Alternatives to animal experiments
, Development of a moltimodal wearable device for rats
, Developmental toxicity
, Stem cell engineering
, Notch-Delta signaling
Research theme for competitive and other funds (20):
- 2024 - 2027 発生毒性リスク評価に資するシグナル伝達かく乱作用を基にしたNAMsの開発
- 2023 - 2027 DXによるin vivo毒性評価技術の発展的継承と一般化
- 2022 - 2026 ハイドロゲルと液体金属から構成される超ソフト電子機械システムに関する研究
- 2023 - 2026 発達神経毒性の迅速化・高精度・省動物に資する新規評価手法開発のための研究
- 2022 - 2025 化学物質のシグナルかく乱作用を基にした新規in vitro催奇形性評価原理の解明
- 2022 - 2025 化学物質のシグナルかく乱作用を基にした新規in vitro催奇形性評価原理の解明
- 2022 - 2025 シグナルかく乱作用に基づく新規ヒト発生毒性試験法による核酸医薬品の安全性評価
- 2022 - 2025 ヒトiPSレポーター細胞を用いたシグナルかく乱を指標とする発生毒性試験法
- 2020 - 2023 Engineering organoids on a chip based on tissue engineering approaches
- 2020 - 2023 Three-dimensional cutlure for hari regenerative medicine
- 2020 - 2023 ウェアラブルデバイスを用いたハイスループット毒性解析システムの開発
- 2020 - 2022 Controlling bi-directional Notch-Delta signalling in hippocampal neural stem cells to enhance the self-renewal and the neurogenesis
- 2018 - 2020 Controlling bi-directional Notch-Delta signaling in human iPSC derived dopaminergic neuron using multivalent protein.
- 2019 - 2020 In vitro 全身毒性評価チップデバイスの開発
- 2018 - 2020 AAVとクラスター化タンパク質の併用によるin vivo神経幹細胞制御法の開発
- 2019 - 2019 リガンドクラスタ化によるiPSC 由来ドーパミン神経細胞の大量作製
- 2013 - 2018 Development of reporter mice enabling detection of epigenetic toxicity in the conventional toxicity tests
- 2016 - 2018 クラスタ化Deltaによるヒト多能性幹細胞由来神経幹細胞のNotchシグナル制御
- 2013 - 2016 Analysis of tissue developments regulated by bi-directional Notch-Delta signal
- 2013 - 2015 組織機能回復の革新を目指した細胞パーティ編成技術の開発
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Papers (12):
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Yusuke Okubo, Yoko Hirabayashi, Junji Fukuda. Advances in genomic toxicology: In vitro developmental toxicity test based on signal network disruption dynamics. Current Opinion in Toxicology. 2024. 39. 100489-100489
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Tatsuto Kageyama, Akihiro Shimizu, Riki Anakama, Rikuma Nakajima, Kohei Suzuki, Yusuke Okubo, Junji Fukuda. Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction. Science Advances. 2022. 8. 42. eadd4603
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Yuji Isano, Hajime Fujita, Koki Murakami, Sijie Ni, Yuta Kurotaki, Tamami Takano, Yutaka Isoda, Ryosuke Matsuda, Fumika Nakamura, Yuuki Nishitai, et al. Transparent and Breathable Ion Gel-Based Sensors toward Multimodal Sensing Ability. Advanced Materials Technologies. 2022. 2200209-2200209
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Seiya Kanno, Kashu Mizota, Yusuke Okubo, Tatsuto Kageyama, Lei Yan, Junji Fukuda. Luciferase assay system to monitor fibroblast growth factor signal disruption in human iPSCs. STAR Protocols. 2022. 3. 2. 101439-101439
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Seiya Kanno, Yusuke Okubo, Tatsuto Kageyama, Lei Yan, Junji Fukuda. Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals. Journal of bioscience and bioengineering. 2022. 133. 3. 291-299
more...
MISC (2):
Patents (3):
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物質の細胞内導入法
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METHOD OF TRANSFERRING SUBSTANCE INTO CELL
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METHOD OF TRANSFERRING SUBSTANCE INTO CELL
Lectures and oral presentations (13):
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シグナルかく乱作用を基にしたin vitro発生毒性試験法の開発とその検出機構の解明に向けて
(第51回日本毒性学会学術年会 2024)
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シグナルかく乱作用のダイナミクスを基にしたin vitro発生毒性試験法
(「生殖発生毒性試験代替法の現状」 シンポジウム 2024)
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シグナルかく乱のリアルタイム計測を基にした in vitro 発生毒性試験
(第9回 日本医療研究開発機構 レギュラトリーサイエンス公開シンポジウム 2023)
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Developmental toxicity detection via dynamics of FGF-SRF signal disruption in human iPSC-based assay
(13TH Global Summit on Regulatory Science (GSRS23) In-Person Annual conference. 2023)
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生細胞リアルタイム発光システムを用いた高精度・ハイスループットな新規発生毒性試験法
(AMEDキャタリストユニット 第11回Top Runners in TRS. 2023)
more...
Education (3):
- 2007 - 2010 The Graduate University for Advanced Studies School of Life Science Department of Genetics
- 2005 - 2007 Saitama University Graduate School of Science and Engineering
- 2001 - 2005 Saitama University
Professional career (1):
- PhD. (The Graduate University for Advanced Studies)
Work history (11):
- 2024/04 - 現在 National Institute of Health Sciences Cellular &Molecular Toxicology division, Biological Safety Research Center Chief
- 2023/04 - 現在 Yokohama National University Institute of Advanced Sciences Visiting Associate Professor
- 2022/12 - 現在 Kanagawa Institute of Industrial Science and Technology
- 2018/02 - 2024/03 National Institute of Health Sciences Division of Toxicology Senior Researcher
- 2020 - 2022 Yokohama National University
- 2021 - Okayama University
- 2016/02 - 2018/01 Japan Society for the Promotion of Science Overseas Research Fellowships
- 2016/02 - 2018/01 University of California, Berkeley
- 2014/04 - 2016/01 National Institute of Health Sciences Division if Toxicology Senior Researcher
- 2010/09 - 2014/03 National Institute of Health Sciences Resercher
- 2010/04 - 2010/08 National Institute of Genetics Resercher
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Committee career (1):
- 2020/05 - 現在 The Pharmaceuticals and Medical Devices Agency (PMDA) External Expert (Toxicology)
Awards (6):
Association Membership(s) (5):
日本先天異常学会
, 日本動物実験代替法学会
, 日本発生生物学会
, 日本毒性学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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