Niki Toshiro

ニキトシロウ | Niki Toshiro

Affiliation and department：
Job title：助教

Research field (1)： Immunology

Research keywords (3)：免疫制御 , レクチン , ガレクチン

Research theme for competitive and other funds (11)：

2022 - 2025 Examination of the effect of combination therapy of galectin-9 and epigallocatechin gallate on hepatocellular carcinoma
2021 - 2024 Functional elucidation of two forms of Galectin-9 and their potential application to diagnosis
2019 - 2022 Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis
2017 - 2020 Matricellular proteins as severity markers for disaster or tropical infectious diseases
2016 - 2019 A study on preparation of single receptor specific lectin and its usefulness

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Papers (116)：

Toshiaki Kono, Shintaro Fujihara, Kyoko Oura, Hisakazu Iwama, Koji Fujita, Naoki Fujita, Kei Takuma, Masahiro Ono, Daisuke Namima, Hiroki Yamana, et al. Antitumor Effect of Galectin-9 on Cell Proliferation and Tumor Growth of Human Duodenal Adenocarcinoma Cells. Anticancer research. 2023. 43. 8. 3769-3777
Li Du, Mohamed S Bouzidi, Akshay Gala, Fred Deiter, Jean-Noël Billaud, Stephen T Yeung, Prerna Dabral, Jing Jin, Graham Simmons, Zain Y Dossani, et al. Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells. Journal of molecular cell biology. 2023
Zhe Yuan, Leila B Giron, Colin Hart, Akwasi Gyampoh, Jane Koshy, Kai Ying Hong, Toshiro Niki, Thomas A Premeaux, Lishomwa C Ndhlovu, Claire Deleage, et al. Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice. AIDS (London, England). 2023. 37. 4. 571-577
Hiroko Iwasaki-Hozumi, Yosuke Maeda, Toshiro Niki, Haorile Chagan-Yasutan, Gaowa Bai, Takashi Matsuba, Daisuke Furushima, Yugo Ashino, Toshio Hattori. Plasma N-Cleaved Galectin-9 Is a Surrogate Marker for Determining the Severity of COVID-19 and Monitoring the Therapeutic Effects of Tocilizumab. International journal of molecular sciences. 2023. 24. 4
Bao-Tram Thi Tran, Aurore Gelin, Sylvère Durand, Matthieu Texier, Amaury Daste, Clémence Toullec, Karim Benihoud, Ingrid Breuskin, Philippe Gorphe, Florence Garic, et al. Plasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors. Oncoimmunology. 2023. 12. 1. 2150472-2150472

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MISC (23)：

河野寿明, 藤田直樹, 琢磨慧, 波間大輔, 山名浩喜, 小林聖幸, 加藤清人, 鎌田英紀, 仁木敏朗, 平島光臣, et al. Galectin-9の十二指腸癌に対する増殖抑制効果;in Vitroの検討. 日本消化器病学会雑誌(Web). 2019. 116
Koji Fujita, Toshiro Niki, Takashi Himoto, Tsutomu Masaki. Serum galectin-9 levels are correlated to liver fibrosis regardless of chronic inflammation or hepatocellular carcinoma complications. HEPATOLOGY. 2017. 66. 241A-241A
Shravan Madireddi, So-Young Eun, Amit K. Mehta, Aruna Birta, Dirk M. Zajonc, Nozomu Nishi, Toshiro Niki, Mitsuomi Hirashima, Taylor H. Schreiber, Eckhard R. Podack, et al. Galectin-9 Controls the Activity of DR3 (TNFRSF25) in Suppressing Immunity. JOURNAL OF IMMUNOLOGY. 2016. 196
Claire Lhuillier, Clement Barjon, Toshiro Niki, Aurore Gelin, Nadira Delhem, Mitsuomi Hirashima, Ming Wei, Olivier Dellis, Pierre Busson. Exploration of the signaling pathways triggered by exogenous galectin-9 in human T and B cells. CANCER IMMUNOLOGY RESEARCH. 2016. 4. 1
浩日勒, 浩日勒, 山内聡, 山内聡, 工藤大介, 工藤大介, 仁木敏朗, 芦野有悟, 芦野有悟, 服部俊夫, et al. Galectin-9は重症敗血症の免疫・炎症反応に関連する可能性がある. エンドトキシン血症救命治療研究会誌. 2015. 19. 1. 121

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Patents (4)：

Anti-galectin-9 antibody and methods of use thereof
ガレクチンタンパク質を用いるレトロウイルスの潜伏感染状態の逆転法
ガレクチン9を分泌する細胞、その製造方法及びその用途
マスト細胞安定化剤

Books (1)：

Efficient Production of Osteopontin-Encapsulating Exosome by LPS Stimulated THP-1 Macrophages
2021 ISBN:9789391473457

Education (2)：

- 1994 Hiroshima University
- 1989 Hiroshima University

Professional career (1)：

PhD (Science) (Hiroshima University)

Work history (3)：

2010 - - 香川大学医学部, 助教
1994 - 2004 バイエル薬品研究所, プロジェクトマネージャー
2004 - - 株式会社ガルファーマ, 部長 - 社長

Association Membership(s) (1)：

日本免疫学会

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