Research field (3)：
Pharmaceuticals - chemistry and drug development
, Biophysics
, Pharmaceuticals - analytical and physicochemistry
Research keywords (4)：
相互作用解析
, 動的構造
, NMR
, 構造生物学
Research theme for competitive and other funds (22)：
2022 - 2025 in cell structure-guided drug development by NMR
2021 - 2024 Molecular basis for biosynthetic and degradation systems for tRNA sulfur-modified bases
2023 - 2024 技術集約型オープンイノベーションによるNMR細胞内創薬の実現
2020 - 2023 高活性化合物を創生し創薬標的の枯渇を解消する動的構造創薬技術の確立
2020 - 2023 GTP代謝制御によるウイルス複製阻害技術の開発
2020 - 2022 Development of basic strategy to structurally evaluate the membrane permeation activity of middle-size molecules
2020 - 2022 分子夾雑環境下におけるタンパク質と薬物の動的相互作用解析
2019 - 2022 Identification and Functional Analysis of the Target Molecule of Terrein, a Small Molecule Compound for Application in the Super-Aging Society
2018 - 2022 Analysis of functional dynamics of membrane proteins in different membrane environments
2017 - 2022 in situ functional analyses of membrane proteins by NMR
2018 - 2020 NMR method to obtain structural fingerprints of an intact monoclonal antibody acquired under formulated storage conditions
2015 - 2018 NMR approach for the functional structural analyses of human membrane proteins
2015 - 2017 Investigation of molecular mechanism of transphosphorylation by a phosphatidylinositol kinase
2015 - 2017 Structural biology of the intrinsically disordered region of CagA
2014 - 2017 汎特異的相互作用を基盤とする多剤耐性機構の動的立体構造解析
2014 - 2015 多剤耐性転写制御因子の動的薬剤認識と機能発現のNMR解析
2013 - 2015 X線結晶構造解析・核磁気共鳴法の融合によるキナーゼ複合体の動的立体構造解析
2012 - 2015 Fundamental research for NMR structural analysis of human membrane proteins
2011 - 2013 原核生物多剤耐性トランスポーターの構造揺らぎと薬剤排出活性のNMR解析
2011 - 2012 Structure determination and elucidation of transport mechanism of mitochondrial inner membrane transporter
Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, et al. A High-Resolution Structural Characterization and Physicochemical Study of How a Peptoid Binds to an Oncoprotein MDM2. Chemical Science. 2024
Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B Boxer, et al. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023. 679. 116-121
Tomoki Yanagi, Hiroaki Kikuchi, Koh Takeuchi, Koichiro Susa, Takayasu Mori, Naohiro Takahashi, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yu Hara, et al. ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease. 2023
Jun-ichi Sugiyama, Yuji Tokunaga, Mafumi Hishida, Masahito Tanaka, Koh Takeuchi, Daisuke Satoh, Masahiko Imashimizu. Nonthermal acceleration of protein hydration by sub-terahertz irradiation. Nature Communications. 2023
上田 卓見, 幸福 裕, 竹内 恒, 今井 駿輔, 白石 勇太郎, 嶋田 一夫. 溶液NMR法によるGPCRの活性と直結する動的構造平衡の解明-Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR-ミニ特集 生理学的環境での生体高分子の挙動の観察可能性の追求. 日本結晶学会誌 = Journal of the Crystallographic Society of Japan. 2022. 64. 4. 279-284
廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, 竹内恒, 千田俊哉, 佐々木敦朗, et al. Metabolic regulation by the GTP sensor PI5P4Kβ: towards the treatment of diabetes, cancer cachexia and sarcopenia. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, TILVE Diego, 竹内恒, 千田俊哉, et al. Metabolic dysregulation by disruption of GTP resilience: a new pathological mechanism for metabolic diseases. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
竹内恒, 池田幸樹, 千田美紀, 原田彩佳, 奥脇弘次, 福澤薫, 中川草, 長瀬里沙, 今井美咲, 廣田佳久, et al. Molecular evolution of PI5P4Kβ that underlies the GTP resilience. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
降旗大岳, 降旗大岳, 原田彩佳, 中川草, 竹内恒, 佐々木敦朗, 千田俊哉, 千田俊哉, 加藤龍一, 加藤龍一. Crystal structural analysis of Branchiostoma floridae PI5P4K for investigation of evolution of GTP sensor. 量子ビームサイエンスフェスタ(Web). 2019. 2018
