Ogi Tomoo

オギトモオ | Ogi Tomoo

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Nagoya University

Homepage URL (1)： http://133.6.134.122/wordpress/

Research field (6)： Environmental effects of chemicals , Environmental effects of radiation , Medical biochemistry , Molecular biology , Dermatology , Pathobiochemistry

Research keywords (13)： DNA repair; human genetics; nucleotide excision repair; genome , Human Genetics , DNA修復 , ヌクレオチド除去修復 , 発がん , 突然変異 , 転写と共役したヌクレオチド除去修復 , 放射線DNA損傷 , 乳癌 , タンパク質間相互作用 , ゲノム医科学 , BRCA2 , DNA損傷修復

Research theme for competitive and other funds (29)：

2022 - 2025 薬剤耐性・変異株解析可能なリアルタイム次世代シークエンスによる重症感染症迅速診断
2021 - 2024 転写共役修復 (TCR)の分子メカニズム解明とTCR欠損ヒト遺伝性疾患の分子病態
2020 - 2024 MYRF遺伝子を起点とした発熱時言動異常の病態解明
2020 - 2023 ロングリード配列決定法による放射線被ばく刻印の同定
2020 - 2023 Molecular pathogenesis of human disorders associated with deficiencies in the DNA repair and environmental stress response systems

2019 - 2023 次世代シークエンスによる包括的な重症感染症リキッドバイオプシー

2019 - 2022 Development of new technology to evaluate the transcription-coupling repair factors.

2018 - 2021 Interactome analysis after induction of DNA damage in human cells

2018 - 2021 Elucidation of the molecular pathogenesis of genetic disorders caused by defects in DNA damage response using deep proteomic analysis

2018 - 2021 中部東海地区IRUDゲノム解析拠点-先端情報技術の融合による包括的遺伝子診断の提供

2017 - 2020 DNA double strand break repair factors mutated in a new syndrome with microcephaly

2017 - 2020 ゲノム不安定性疾患群を中心とした希少難治性疾患の次世代マルチオミクス診断拠点構築

2017 - 2020 DNA修復・損傷応答機構の異常により発症するゲノム不安定性疾患の分子病態解明研究

2015 - 2019 Molecular regions of BRCA proteins responsible for cancer suppression

2014 - 2019 The molecular epidemiological study of DNA repair-related genes in post-Chernobyl radiation-induced thyroid cancers

2015 - 2018 Biochemical analysis of transcription coupled nucleotide excision repair factors

2014 - 2018 Mechanism of genomic DNA damage response mediated by acetylation of non-histone proteins

2015 - 2018 ゲノム不安定性を誘発する先天性稀少疾患と小児がんコホートの分子遺伝疫学調査

2014 - 2018 転写共役ヌクレオチド除去修復開始反応のin vitro再構成

2014 - 2017 転写共役修復開始反応の分子機能解析(遺伝性光線過敏症の分子基盤)

2014 - 2017 Identification of novel disease-causing gene mutations in patients with UV-sensitive syndromes

2016 - 2017 小頭症を発症する遺伝性疾患の鑑別診断技術開発

2012 - 2015 Stalled RNA polymerase processing in transcription-coupled nucleotide-excision repair

2012 - 2015 A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

2010 - 2012 Comprehensive analyses of the nucleotide excision repair (NER) molecular mechanisms

2009 - 2011 Mapping of the disease loci using SNP genotyping and identification of the gene by the sequence capture method

2008 - 2009 Functional analyses of DNA polymerases in nucleotide excision repair

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Papers (112)：

Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi. Endogenous aldehyde-induced DNA-protein crosslinks are resolved by transcription-coupled repair. Nature cell biology. 2024
Paniz Farshadyeganeh, Takahiro Yamada, Hirofumi Ohashi, Gen Nishimura, Hiroki Fujita, Yuriko Oishi, Misa Nunode, Shuku Ishikawa, Jun Murotsuki, Yuri Yamashita, et al. Dyssegmental dysplasia Rolland-Desbuquois type is caused by pathogenic variants in HSPG2 - a founder haplotype shared in five patients. Journal of human genetics. 2024
Miyu Misaki, Takuya Takeichi, Michiya Omi, Yasutoshi Ito, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama. Localized epidermolysis bullosa simplex caused by a previously unreported substitution in the linker 12 domain of keratin 14. The Journal of dermatology. 2024
Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, et al. Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. iScience. 2024. 27. 2. 108872-108872
Maiko Shimomura-Ishihara, Takuya Takeichi, Tatsuhiro Noda, Haruka Koizumi, Teruyuki Mitsuma, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama. Natal teeth, hypoplasia of the first toe, and growth retardation in a patient with severe epidermolysis bullosa simplex. The Journal of dermatology. 2023

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MISC (8)：

T. Takeichi, T. Matsumoto, T. Nomura, M. Takeda, H. Niwa, M. Kono, H. Shimizu, T. Ogi, M. Akiyama. A novel NCSTN missense mutation in the signal peptide domain causes hidradenitis suppurativa, which has features characteristic of an autoinflammatory keratinization disease. British Journal of Dermatology. 2020. 182. 2. 491-493
Y. Takahashi, Y. Endo, A. Kusaka-Kikushima, S. Nakamaura, Y. Nakazawa, T. Ogi, M. Uryu, G. Tsuji, M. Furue, S. Moriwaki. An XPA gene splicing mutation resulting in trace protein expression in an elderly patient with xeroderma pigmentosum group A without neurological abnormalities. BRITISH JOURNAL OF DERMATOLOGY. 2017. 177. 1. 253-257
N. Jia, Y. Nakazawa, C. Guo, M. Shimada, M. Sethi, Y. Takahashi, H. Ueda, Y. Nagayama, T. Ogi. Click-iT DNA damage and repair assay. Assay and Drug Development Technologies. 2015. 13. 186-187
Nakazawa Yuka, Ogi Tomoo, Guo Chaowan, Shimada Mayuko, Jia Nan. P-011 XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency(Poster Sessions). 2015. 44. 98-98
OGI Tomoo, NAKAZAWA Yuka, SASAKI Kensaku, GUO Chaowan, YOSHIURA Koh-ichiro, UTANI Atsushi, NAGAYAMA Yuji. Molecular cloning and characterisation of UVSSA, the responsible gene for UV-sensitive syndrome. 生化學. 2013. 85. 3. 133-144

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Patents (4)：

Lectures and oral presentations (4)：

RNA polymerase IIのユビキチン化修飾による転写共役修復開始反応の分子機構とその破綻により発症する哺乳類の神経変性のメカニズム
(第42回日本分子生物学会年会 2019)
希少未診断疾患におけるゲノム解析およびデータ評価パイプラインの構築
(第4回名大医薬系3部局交流シンポジウム 2019)
Mutations in UVSSA cause UV sensitive syndrome
(Responses to DNA damage: from molecular mechanism to human disease 2011)
Mutations in UVSSA cause UV sensitive syndrome
(2011)

Works (16)：

ヌクレオチド除去修復欠損性日光過敏症のウイルス発現系とゲノム解析による網羅的探索
2012 - 2014
紫外線感受性症候群責任因子によるRNAポリメラーゼユビキチン化と待避機構の解析
2012 - 2014
放射線損傷DNA修復過程における複製忠実度の低いDNAポリメラーゼによる突然変異誘発機構の解析
2011 - 2012
DNA修復過程でのヌクレオシドの取り込みを指標とした不正確な修復合成を誘発するDNA修復因子の探索
2010 - 2011
ヌクレオチド除去修復過程における修復DNA合成の分子メカニズムの解明
2010 - 2011

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Professional career (1)：

D. Sci. (Kyoto University)

Work history (4)：

2021/01 - 現在 Nagoya University
2015/04/01 - 現在 Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Professor
2015/04 - 現在 Nagoya University Research Institute of Environmental Medicine (RIeM) Professor of Genetics
2014 - 2015 Nagasaki University

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