Niki Kazuko

Affiliation and department：

Research keywords (4)：包括脳ネットワーク , 酸化ストレス , パーキンソン病 , DJ-1

Research theme for competitive and other funds (4)：

2018 - 2019 最適なBCR-ABL-TKI選択のための簡便なABL変異検出法の確立
2013 - 2014 Analysis of mitochondrial regulation by DJ-1
2011 - 2012 Analysis of neuroprotective function of Parkinson's Disease Gene DJ-1
2010 - 2011 Antioxidative defense mechanism of DJ-1, parkinson's disease related gene

Papers (37)：

Takeshi Niki, Jinro Endo, Kazuko Takahashi-Niki, Tatsuki Yasuda, Asami Okamoto, Yoshiro Saito, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga. DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN. Brain research. 2020. 1729. 146641-146641
Atsuko Honda, Yasuyuki Ito, Kazuko Takahashi-Niki, Natsuki Matsushita, Motohiro Nozumi, Hidenori Tabata, Kosei Takeuchi, Michihiro Igarashi. Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules. JOURNAL OF NEUROSCIENCE. 2017. 37. 15. 4046-4064
Kazuko Takahashi-Niki, Takeshi Niki, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga. Transcriptional regulation of DJ-1. Advances in Experimental Medicine and Biology. 2017. 1037. 89-95
Kazuko Takahashi-Niki, Yoko Ganaha, Takeshi Niki, Shota Nakagawa, Izumi Kato-Ose, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga. DJ-1 activates SIRT1 through its direct binding to SIRT1. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2016. 474. 1. 131-136
Kazuko Takahashi-Niki, Izumi Kato-Ose, Hiroaki Murata, Hiroshi Maita, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga. Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 29. 17838-17847

ｍore...

MISC (4)：

T. Niki, K. Niki-Takahashi, A. Okamoto, J. Endo, T. Miyakawa, H. Ariga, S. M. M. Iguchi-Ariga. Oxidative stress-response by DJ-1 and its binding compounds. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 66-66
Shizuma Ishikawa, Takahiro Taira, Kazuko Takahashi-Niki, Takeshi Niki, Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga. Human DJ-1-specific transcriptional activation of the tyrosine hydroxylase gene. NEUROSCIENCE RESEARCH. 2010. 68. E305-E306
Kimi Sakai, Hiroshi Maita, Kazuko Takahashi-Niki, Sanae M. M. Ariga, Hiroyoshi Ariga. Loss of DJ-1 affects mitochondrial functions. NEUROSCIENCE RESEARCH. 2010. 68. E308-E308
Motohiro Nozumi, Kazuko Takahashi-Niki, Michihiro Igarashi. Systematic immunostaining and RNAi experiments for finding the novel molecular marker candidates of the growth cone. NEUROSCIENCE RESEARCH. 2007. 58. S201-S201

Professional career (1)：

Work history (10)：

2016/04 - 現在北海道大学病院薬剤部試験研究室室長
2009/06 - 2016/03 Hokkaido University Faculty of Pharmaceutical Sciences
2009/04 - 2009/05 Hokkaido University Graduate School of Agriculture Research Faculty of Agriculture
2007/12 - 2009/03 Hokkaido University Faculty of Pharmaceutical Sciences
2006/04 - 2007/12 新潟大学医歯学総合研究科博士研究員

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