Rchr
J-GLOBAL ID:201201004766621952
Update date: Apr. 03, 2024
Sakakura Masayoshi
サカクラ マサヨシ | Sakakura Masayoshi
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
http://www-mls.tsurumi.yokohama-cu.ac.jp/fsb/sakakura/
Research field (1):
Pharmaceuticals - analytical and physicochemistry
Research keywords (10):
脱髄疾患
, ミエリン
, P0
, MPZ
, PMP22
, Amyloid precursor protein
, C99
, Charcot-Marie-Tooth disease
, NMR
, structural biology
Research theme for competitive and other funds (12):
- 2021 - 2024 Structural analyses of PMP22 and MPZ to elucidate the molecular mechanism of Charcot-Marie-Tooth disease
- 2019 - 2022 Redox sensing by membrane proteins via cysteine residues in the TM region as studied by using solution NMR
- 2018 - 2021 Structural analyses of PMP22 and MPZ to reveal the molecular basis of Charcot-Marie-Tooth disease
- 2015 - 2018 NMR approach for the functional structural analyses of human membrane proteins
- 2014 - 2017 Structural analyses of MAPEG family membrane proteins using NMR
- 2012 - 2015 Fundamental research for NMR structural analysis of human membrane proteins
- 2012 - 2014 Study of an AMPAR auxiliary transmembrane protein, stargazin
- 2007 - 2008 コンタクトシフトと立体整列同位体標識法を利用した新規蛋白質相互作用解析法の開発
- 2006 - 2007 NMRを用いた生体機能分子-標的蛋白質複合体の相互作用解析法の開発
- 2005 - 2006 酸素分子を利用した生体高分子複合体の相互作用界面を決定する新規NMR解析法の開発
- 2005 - 2005 NMRを用いた生体機能分子・標的蛋白質複合体の相互作用解析法の開発
- 2003 - 2003 原子レベルでの病態解明に向けたハイスループットな分子間相互作用解析法の開発
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Papers (30):
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Masayoshi Sakakura, Mikio Tanabe, Masaki Mori, Hideo Takahashi, Kazuhiro Mio. Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero. Structure (London, England : 1993). 2023
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Bilge Argunhan, Masayoshi Sakakura, Negar Afshar, Misato Kurihara, Kentaro Ito, Takahisa Maki, Shuji Kanamaru, Yasuto Murayama, Hideo Tsubouchi, Masayuki Takahashi, et al. Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex. eLife. 2020. 9. e52566
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Masayoshi Sakakura, Yumi Ohkubo, Hiraku Oshima, Suyong Re, Masahiro Ito, Yuji Sugita, Hideo Takahashi. Structural Mechanisms Underlying Activity Changes in an AMPA-type Glutamate Receptor Induced by Substitutions in Its Ligand-Binding Domain. Structure. 2019. 27. 11. 1698-1709.e5
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Bilge Argunhan, Masayoshi Sakakura, Negar Afshar, Misato Kurihara, Kentaro Ito, Takahisa Maki, Shuji Kanamaru, Yasuto Murayama, Hideo Tsubouchi, Masayuki Takahashi, et al. Rad51 Interaction Analysis Reveals a Functional Interplay Among Recombination Auxiliary Factors. 2019
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Carlos G. Vanoye, Masayoshi Sakakura, Rose M. Follis, Alexandra J. Trevisan, Malathi Narayan, Jun Li, Charles R. Sanders, Bruce D. Carter. Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology. Journal of Biological Chemistry. 2019. 294. 32. 12054-12065
more...
MISC (5):
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田村 真由美, 藤井 智彦, 坂倉 正義, 武内 智春, 畑中 朋美, 高橋 栄夫, 岸本 成史, 荒田 洋一郎. ガレクチン-2のS-ニトロソ化部位のLC-MS/MSによる解析. 日本薬学会年会要旨集. 2019. 139年会. 3. 102-102
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Hiraku Oshima, Suyong Re, Masayoshi Sakakura, Hideo Takahashi, Yuji Sugita. Effects of T686A Mutation on the Structural Stability of the AMPA Receptor Ligand-Binding Domain. BIOPHYSICAL JOURNAL. 2018. 114. 3. 125A-125A
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坂倉 正義, 田村 真由美, 武内 智春, 荒田 洋一郎, 高橋 栄夫. NMRを用いたS-ニトロソ化によるガレクチン-2の酸化的失活防御メカニズムの解明. 生命科学系学会合同年次大会. 2017. 2017年度. [1AT26-09(1P
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Sakakura M., Shimba N., Takahashi H., Arata Y., Fujii I., Shimada I. Structural analysis of catalytic antibodies. Biophysics. 1998. 38. 2. S44
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SAKAKURA M., SHIMBA N., TAKAHASHI H., TANAKA F., FUJII I., SHIMADA I. NMR study of the active site of catalytic antibody. Biophysics. 1997. 37. S21
Books (2):
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NMRによる有機材料分析とその試料前処理、データ解釈
技術情報協会 2021 ISBN:9784861048609
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物理系薬学〈3〉生体分子・化学物質の構造決定 (スタンダード薬学シリーズ)
東京化学同人 2006 ISBN:4807914537
Professional career (1):
Work history (6):
- 2022/04 - 現在 Yokohama City University
- 2013/04 - 2022/03 Yokohama City University International College of Arts and Sciences Medical Life Science Graduate School of Medical Life Science Department of Medical Life Science Graduate School of Medical Life Science Assistant Professor
- 2012/04 - 2013/03 Yokohama City University Graduate School of Nanobioscience Assistant Professor
- 2011/06 - 2012/03 Yokohama City University Graduate School of Nanobioscience Research Assistant Professor
- 2008/04 - 2011/05 Vanderbilt University School of Medicine Research Fellow
- 2001/06 - 2008/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Assistant Professor
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