KUMAMOTO TAKUYA

クマモトタクヤ | KUMAMOTO TAKUYA

Affiliation and department：

Research field (1)： Clinical pharmacy

Research keywords (1)： Synthetic organic chemistry

Research theme for competitive and other funds (14)：

2024 - 2027 Design and synthesis of benzoisochromane derivatives without quinone structure and their investigation as antimicrobial compounds
2022 - 2027 Development of multivalent PET tracers for the early diagnosis of Alzheimer's disease
2023 - 2026 Development of dual-action antimicrobial agents effective against antimicrobial resistant bacteria
2019 - 2024 Generation of highly functionalized naphthoquiones based on the mechanistic understanding of biosynthetic enzymes
2019 - 2023 Studies towards total synthesis of anti-HIV conocurvone and construction of trimeric structure using benzyne intermediates

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Papers (88)：

Takahiro Shirai*, Yusuke Migitera, Ryo Nakajima, and Takuya Kumamoto*. Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes Using Hydrosilane at Room Temperature. J Org Chem. 2024. 89. 4. 2787-2793
Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells. Front. Pharmacol., Sec. Neuropharmacology. 2023. 14. 1284586
Makoto Hashimoto, Susumu Watari, Takaaki Taguchi, Kazuki Ishikawa, Takuya Kumamoto, Susumu Okamoto, and KojiIchinose. Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction. Angew. Chem. Int. Ed. 2022. e202214400
Hiroki Miyake, Ryo Nakajima, and Takuya Kumamoto*. Asymmetric Total Synthesis of Brasiliquinones B and C via Oxidative Cyclization of a Hydroquinone-Silyl Enol Ether Hybrid. Journal of Organic Chemistry. 2022. 87. 18. 12491-12497
Takuya Kumamoto, Mika Kainuma, Azusa Takahashi, Yoshika Matsuo, Kazuaki Katakawa, Takaaki Taguchi, Koji Ichinose. Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer. Molecules. 2021. 26. 21. 6397-6397

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MISC (104)：

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Patents (2)：

誘導型一酸化窒素合成酵素(iNOS)を阻害するクマリン化合物
グアンジン化合物及びグアニジン化合物のポリマー固定化複合体

Books (3)：

Chapter 1. Recent Progress in Aryne Cycloaddition Reactions
NOVA SCIENCE PUBLISHERS 2019 ISBN:9781536154207
<B>Superbases for Organic Synthesis</B>: Guanidines, Amidines, Phosphazenes and Related Organocatalysts
2009
<B>Superbases for Organic Synthesis</B>: Guanidines, Amidines, Phosphazenes and Related Organocatalysts
2009

Lectures and oral presentations (55)：

Synthetic studies toward aromatic polyketide antibiotics
(International Conference in Organic Synthesis & Sustainable Materials 2024 2024)
Total Synthesis of Brasiliquinones
(International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023 2023)
温和な条件の不活性型オレフィンに対する還元的ヘック反応の開発
(日本薬学会第143年会 2023)
不活性型オレフィンに対する還元的ヘック反応の開発
(第48回反応と合成の進歩シンポジウム実行委員会 2022)
Synthetic Studies toward Natural Xanthone Blennolides via Spirochromanones
(ICPAC Kota Kinabalu 2022 2022)

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Works (6)：

シロキシジエンを用いる不斉 Diels-Alder 反応(ファルマシア 2001)
エチレンジアニオン等価体を用いたシクロプロパン化反応(ファルマシア 1995)
Guanidines in Organic Synthesis(Synthesis 2006)
構造に混乱のある Kinamycin 類の化学(有機合成化学協会誌 2004)
赤外線で有機化合物を見分ける(化学と教育2010)

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Education (6)：

- 1996 The University of Tokyo
- 1996 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- 1993 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- 1993 The University of Tokyo
- 1991 Kanazawa University Faculty of Pharmaceutical Sciences

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Professional career (1)：

博士 (東京大学)

Work history (7)：

2017/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
2010/04 - 2017/03 Musashino University Professor
2007/06 - 2010/03 Chiba University Associate Professor
2005/04 - 2007/05 Chiba University Lecturer
1997/04 - 2005/03 Chiba University Research Associate

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Committee career (7)：

2023/09 - 2025/09 International Pharmacy Federation International Pharmacy Federation, Board of Pharmaceutical Sciences, Special Interest Group New Medicines, Chair
2020/05 - 2021/05 有機合成化学協会中国四国支部有機合成化学協会中国四国支部支部幹事
2016/04 - 2021/03 Pharmaceutical Society of Japan International Affairs
2020/02 - 2021/02 日本薬学会中国四国支部日本薬学会中国四国支部支部幹事
2012/04 - 2019/09 International Pharmacy Federation Board of Pharmaceutical Sciences, Special Interest Group on Drug Design and Discovery

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Awards (2)：

2009 - 日本薬学会関東支部奨励賞
2004 - 有機合成化学協会研究企画賞

Association Membership(s) (6)：

The Society of Iodine Science , The Japanese Association of Molecular Target Therapy of Cancer , Chemical Society of Japan , International Federation of Pharmacy , The Society of Synthetic Organic Chemistry, Japan , Pharmaceutical Society of Japan

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