Yuyama Kohei

ユヤマコウヘイ | Yuyama Kohei

Affiliation and department：
Homepage URL (1)： http://sphingolipidfunction.com

Research field (2)： Neuroscience - general , Structural biochemistry

Research theme for competitive and other funds (6)：

2022 - 2025 デジタル測定による脳内アミロイドβ蓄積とアミロイドβ結合エクソソーム量の相関解析
2018 - 2021 The mechnisms of physiological exosome delivery to neurons
2017 - 2021 画期的医薬品等の創出をめざす脂質の生理活性と機能の解明
2014 - 2017 Exosome-like synthetic liposomes containing glycosphingolipids for therapy of Alzheimer's disease
2011 - 2011 Clearance of neuronal exosomes in brain平成25年5月20日現在

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Papers (48)：

Yukifusa Igeta, Isao Hemmi, Kohei Yuyama, Yasuyoshi Ouchi. Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease. Scientific reports. 2024. 14. 1. 4658-4658
Kohei Yuyama, Hui Sun, Risa Fujii, Isao Hemmi, Koji Ueda, Yukifusa Igeta. Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer’s disease pathogenesis. Brain. 2023
Mariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde. Stereochemistry-activity relationship of ceramide-induced exosome production to clear amyloid-β in Alzheimer's disease. Chirality. 2023. 35. 9. 577-585
Kohei Yuyama, Hui Sun, Yasuyuki Igarashi, Kenji Monde, Takumi Hirase, Masato Nakayama, Yoichi Makino. Immuno-digital invasive cleavage assay for analyzing Alzheimer's amyloid ß-bound extracellular vesicles. Alzheimer's Research & Therapy. 2022. 14. 1. 140-140
Yuta Murai, Takumi Honda, Kohei Yuyama, Daisuke Mikami, Koichi Eguchi, Yuichi Ukawa, Seigo Usuki, Yasuyuki Igarashi, Kenji Monde. Evaluation of Plant Ceramide Species-Induced Exosome Release from Neuronal Cells and Exosome Loading Using Deuterium Chemistry. International Journal of Molecular Sciences. 2022. 23. 18. 10751-10751

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MISC (18)：

Kohei Yuyama, Hui Sun, Kenji Monde, Takumi Hirase, Yoichi Makino. Study of extracellular vesicle biomarkers for detection of brain amyloid accumulation. 2024. 7. 8. 663-667
湯山耕平, 孫慧, 門出健次, 平瀬匠, 牧野洋一. 細胞外小胞のデジタル検出法開発-アルツハイマー病早期検出への応用-. Medical Science Digest. 2023. 49. 432-435
Kohei Yuyama, Yasuyuki Igarashi. Linking glycosphingolipids to Alzheimer's amyloid-ß: extracellular vesicles and functional plant materials. Glycoconjugate journal. 2022. 39. 5. 613-618
Kohei Yuyama, Yasuyuki Igarashi. Roles of sphingolipids in neurodegenerative diseases. Journal of Japanese Biochemical Society. 2020. 92. 5. 640-648
湯山耕平, 江口晃一, 五十嵐靖之. 広がりを見せる食餌性植物セラミドの生体調節機能. バイオサイエンスとインダストリー. 2020. 78. 4. 302-307

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Books (5)：

Lectures and oral presentations (2)：

Ceramide-dependent exosome production and their functions in neurodegenerative diseases
(2019)
Sphingoid long chain bases: Their structural diversity, absorption, and functions for skin improvement
(7th International Singapore Lipid Symposium (ISLS7) 2018)

Education (3)：

Professional career (1)：

Work history (4)：

2015/06 - 現在 Hokkaido University Faculty of Advanced Life Science Associate Professor
2009/04 - 2015/05 Hokkaido University Faculty of Advanced Life Science Assistant Professor
2005/11 - 2009/03 National Center for Geriatrics and Gerontology Department of Alzheimer's Disease Postdoctoral fellow
2002/04 - 2005/10 Tokyo Metropolitan Institute of Medical Science Biomembrane Signaling Project Postdoctral fellow

Committee career (1)：

Awards (3)：

2014/08 - Japanese Sciety of Extracellular Vesicles (JSEV) encouraging prize
2013/04 - International Society for Extracellular Vesicles (ISEV) Young Investigator Award
2012/10 - 第5回セラミド研究会学術集会 Young Investigator Award

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