Kiyozumi Daiji

キヨズミダイジ | Kiyozumi Daiji

Affiliation and department：
Other affiliations (2)：

National Institute for Basic Biology
Osaka University Institute for Protein Research

Homepage URL (1)： https://twitter.com/DaijiKiyozumi

Research field (10)： Functional biochemistry , Genomics , Molecular biology , Animals: biochemistry, physiology, behavioral science , Zoological sciences , Urology , Cell biology , Laboratory animal science , Morphology, anatomy , Developmental biology

Research keywords (22)： endocrine , sperm maturation , epididymis , NICOL, NELL-interacting cofactor for lumicrine signaling , NELL2 , laminin inactivated mice , in situ integrin ligand detection , in situ integrin binding , ゲノム生物学 , multicellular system , lumicrine , genome editing , reproductive biology , Experimental animals , Genetics , Developmental Biology , Organogenesis , Epithelial-mesencymal interactions , Fraser syndrome , cell adhesion , 細胞外環境 , extracellular matrix

Research theme for competitive and other funds (15)：

2024 - 2026 長期安定的な生殖の基盤となる精子成熟制御システム
2024 - 2025 プロテオリシスを介した精子成熟メカニズムの解明
2024 - 2025 新たな男性避妊薬開発の基盤となる精子成熟機構の解明
2023 - 2025 生殖路による精子成熟の分子機構解明
2021 - 2025 ルミクリンによる上皮組織の高次階層制御

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Papers (41)：

Nguyen Thi Thanh Tuyen, Keizo Tokuhiro, Keisuke Shimada, Haoting Wang, Daisuke Mashiko, Shingo Tonai, Daiji Kiyozumi, Masahito Ikawa. Gene-deficient mouse models established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024. 12. 1. 1411162-1411162
Daiji Kiyozumi. Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome. Reproductive Biology and Endocrinology. 2024. 22. 1. 40
Daiji Kiyozumi. Busulfan administration replicated the characteristics of the epididymal initial segment observed in mice lacking testis-epididymis lumicrine signaling. Journal of Reproduction and Development. 2024. 70. 2. 104-114
Daiji Kiyozumi. Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract. Reproductive Biology and Endocrinology. 2024. 22. 1. 3
Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin-Yi Chang, Masahito Ikawa. CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice. Andrology. 2023

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MISC (8)：

Daiji Kiyozumi. Regulation of sperm maturation by lumicrine signaling mediated by secreted protein NELL2. 2022. 94. 4. 560-564
淨住大慈, 伊川正人. 精子の成熟機構と受精能. ファルマシア. 2022. 58. 1. 18-23
淨住大慈, 伊川正人. 精子が「一人前」になる仕組み - 「ルミクライン因子」が司る精子成熟の分子メカニズムに迫る. academist Journal. 2020
淨住大慈. 精子が受精能をもつための鍵分子を発見!. 化学. 2020. 75. 75-75
淨住大慈, 伊川正人. 新規なシグナル伝達システム「ルミクライン」による雄性生殖路の機能と妊孕性の制御. 実験医学. 2020. 38. 18. 3132-3135

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Lectures and oral presentations (16)：

経管腔シグナル伝達ルミクリンによる精子成熟の制御
(第4回有性生殖研究会 2024)
The molecular mechanisms of mammalian sperm maturation regulated by lumicrine signaling
(2023)
ルミクリン:精子の成熟を制御する新しい分泌シグナル伝達
(名古屋大学大学院理学研究科アドバンス生命理学特論/GTR セミナー 2023)
経管腔シグナル伝達「ルミクリン」による雄性生殖能力の制御
(新学術研究領域研究「全能性プログラム:デコーディングからデザインへ」ウェビナー 2023)
精巣分泌因子Ts-1はルミクリンシグナル伝達を介した雄の妊孕性制御に必須である
(第37回日本免疫生殖学会総会・学術集会 2022)

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Professional career (1)：

博士(理学) (大阪大学)

Work history (4)：

2024/04 - 現在 National Institutes of Natural Sciences National Institute for Basic Biology
2023/04 - 現在 Osaka University Institute for Protein Research
2021/10 - 現在 Japan Science and Technology Agency
2023/04 - 2024/03 Nagoya University Research Institute of Environmental Medicine Designated lecturer

Awards (7)：

2023/04 - UBE学術振興財団第63回学術奨励賞
2022/11 - 第37回日本生殖免疫学会総会・学術集会学会賞
2022/03 - 2021 NIKON JOICO AWARD Runner-up Prize
2020/11 - The 15th International Symposium of the Institute Network for Biomedical Sciences Early Career Investigator Award NELL2 is necessary for epididymal differentiation and male fertility
2020/01 - 大阪大学微生物病研究所令和元年度研究業績発表会最優秀学術賞

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Association Membership(s) (4)：

JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , The Japanese Society for Connective TIssue Research , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , 日本分子生物学会

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