Rchr
J-GLOBAL ID：201301065071790520   Update date: Nov. 07, 2024

Kiyozumi Daiji

キヨズミ ダイジ | Kiyozumi Daiji
Affiliation and department：
Japan Science and Technology Agency

About Japan Science and Technology Agency


Other affiliations (2)：
Homepage URL  (1)： https://twitter.com/DaijiKiyozumi
Research field  (10)： Functional biochemistry ,  Genomics ,  Molecular biology ,  Animals: biochemistry, physiology, behavioral science ,  Zoological sciences ,  Urology ,  Cell biology ,  Laboratory animal science ,  Morphology, anatomy ,  Developmental biology
Research keywords  (22)： endocrine ,  sperm maturation ,  epididymis ,  NICOL, NELL-interacting cofactor for lumicrine signaling ,  NELL2 ,  laminin inactivated mice ,  in situ integrin ligand detection ,  in situ integrin binding ,  ゲノム生物学 ,  multicellular system ,  lumicrine ,  genome editing ,  reproductive biology ,  Experimental animals ,  Genetics ,  Developmental Biology ,  Organogenesis ,  Epithelial-mesencymal interactions ,  Fraser syndrome ,  cell adhesion ,  細胞外環境 ,  extracellular matrix
Research theme for competitive and other funds  (16)：
  • 2024 - 2026 長期安定的な生殖の基盤となる精子成熟制御システム
  • 2024 - 2025 新規な経管腔シグナル伝達「ルミクリン」の構造生物学的理解
  • 2024 - 2025 プロテオリシスを介した精子成熟メカニズムの解明
  • 2024 - 2025 新たな男性避妊薬開発の基盤となる精子成熟機構の解明
  • 2023 - 2025 生殖路による精子成熟の分子機構解明
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Papers (42)：
  • Nguyen Thi Thanh Tuyen, Keizo Tokuhiro, Keisuke Shimada, Haoting Wang, Daisuke Mashiko, Shingo Tonai, Daiji Kiyozumi, Masahito Ikawa. Gene-deficient mouse models established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024. 12. 1. 1411162-1411162
  • Daiji Kiyozumi. Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome. Reproductive Biology and Endocrinology. 2024. 22. 1. 40
  • Daiji Kiyozumi. Busulfan administration replicated the characteristics of the epididymal initial segment observed in mice lacking testis-epididymis lumicrine signaling. Journal of Reproduction and Development. 2024. 70. 2. 104-114
  • Daiji Kiyozumi. Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract. Reproductive Biology and Endocrinology. 2024. 22. 1. 3
  • Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin-Yi Chang, Masahito Ikawa. CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice. Andrology. 2023
ｍore...
MISC (9)：
  • 淨住大慈. プロテオリシスを介した精子成熟メカニズムの解明. 日本応用酵素協会誌. 2024. 58. 35-37
  • Daiji Kiyozumi. Regulation of sperm maturation by lumicrine signaling mediated by secreted protein NELL2. 2022. 94. 4. 560-564
  • 淨住大慈, 伊川正人. 精子の成熟機構と受精能. ファルマシア. 2022. 58. 1. 18-23
  • 淨住大慈, 伊川正人. 精子が「一人前」になる仕組み - 「ルミクライン因子」が司る精子成熟の分子メカニズムに迫る. academist Journal. 2020
  • 淨住大慈, 伊川正人. 新規なシグナル伝達システム「ルミクライン」による雄性生殖路の機能と妊孕性の制御. 実験医学. 2020. 38. 18. 3132-3135
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Lectures and oral presentations  (73)：
  • Regulation of Reproductive Tract Functions through Lumicrine Signaling
    (2024)
  • 精子の機能成熟におけるUPR関与の可能性
    (第17回小胞体ストレス研究会 2024)
  • 経管腔シグナル伝達ルミクリンによる精子成熟の制御
    (第4回有性生殖研究会 2024)
  • O-結合型糖鎖を有するタンパク質 NICOLの化学合成とその機能解明
    (日本化学会第104春季年会 2024)
  • Regulatory mechanism of epithelial integrity and function by lumicrine signaling
    (The 2nd JST International Symposium “Dynamics of Cellular Interactions in Multicellular Systems” 2024)
ｍore...
Professional career (1)：
  • 博士(理学) (大阪大学)
Work history (4)：
  • 2024/04 - 現在 National Institutes of Natural Sciences National Institute for Basic Biology
  • 2023/04 - 現在 Osaka University Institute for Protein Research
  • 2021/10 - 現在 Japan Science and Technology Agency
  • 2023/04 - 2024/03 Nagoya University Research Institute of Environmental Medicine Designated lecturer
Awards (7)：
  • 2023/04 - UBE学術振興財団 第63回学術奨励賞
  • 2022/11 - 第37回日本生殖免疫学会総会・学術集会 学会賞
  • 2022/03 - 2021 NIKON JOICO AWARD Runner-up Prize
  • 2020/11 - The 15th International Symposium of the Institute Network for Biomedical Sciences Early Career Investigator Award NELL2 is necessary for epididymal differentiation and male fertility
  • 2020/01 - 大阪大学微生物病研究所 令和元年度研究業績発表会 最優秀学術賞
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Association Membership(s) (4)：
JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE ,  The Japanese Society for Connective TIssue Research ,  JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS ,  日本分子生物学会
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