Rchr
J-GLOBAL ID：201401018412604975   Update date: Aug. 27, 2024

Saeki Yasushi

サエキ ヤスシ | Saeki Yasushi
Affiliation and department：
The University of Tokyo The Institute of Medical Science

About The University of Tokyo The Institute of Medical Science


Job title： Professor
Homepage URL  (2)： https://www.ims.u-tokyo.ac.jp/prometa/ ,  https://www.ims.u-tokyo.ac.jp/prometa/en/index.html
Research field  (2)： Molecular biology ,  Functional biochemistry
Research keywords  (5)： Ubiquitin ,  Proteasome ,  Protein degradation ,  MS-based proteomics ,  LLPS
Research theme for competitive and other funds  (24)：
  • 2023 - 2028 Integrated understanding of proteasomal degradation and the ubiquitin code
  • 2023 - 2028 Shin-biology regulated by protein lifetime
  • 2023 - 2028 Mechanism of how the proteasome determines protein lifetime
  • 2023 - 2024 New Frontier for Ubiquitin Biology Driven by Chemo-technologies
  • 2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
Show all
Papers (111)：
  • Yukiko Yoshida, Tsuyoshi Takahashi, Nozomi Ishii, Ichiro Matsuo, Satoshi Takahashi, Haruka Inoue, Akinori Endo, Hikaru Tsuchiya, Meari Okada, Chikara Ando, et al. Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Molecular Cell. 2024. 84. 16. 3115-3127.e11
  • Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, et al. Intrinsic signaling pathways modulate targeted protein degradation. Nature communications. 2024. 15. 1. 5379-5379
  • Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024
  • Takumi Ito, Tomoko Asatsuma-Okumura, Akinori Endo, Junichi Yamamoto, Yoshiko Iwai, Yuki Yamaguchi, Mikihiko Naito, Hiroshi Handa, Yasushi Saeki. ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugs. 2023
  • 中臺 航太, 遠藤 彬則, 冨田 拓哉, 柴田 識人, 出水 庸介, 有竹 浩介, 佐伯 泰. PROTACが誘導するユビキチン化ゾーンと補助因子の解析. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-148]
ｍore...
MISC (103)：
ｍore...
Patents (2)：
Lectures and oral presentations  (20)：
  • Proteasome phase separation triggered by ATP depletion
    (FASEB Science Research Conference 2024 "Ubiquitin and Ub-like proteins" 2024)
  • ユビキチン・プロテアソーム研究の最新動向と創薬開発
    (日本ケミカルバイオロジー学会・産学連携委員会「ケミカルバイオロジーの技術革新」 2024)
  • ユビキチンプロテオミクスによるPROTAC評価
    (京都大学オープンイノベーション機構ミニシンポジウム「創薬プロテオミクス 企業とアカデミアの視点から」 2024)
  • ストレスに応答したプロテアソーム凝縮体形成
    (第46回日本分子生物学会年会「生体分子凝縮体を介するストレスへの適応機構」 2023)
  • プロテアソームによるタンパク質分解と液滴形成
    (第40回バイオメディシナルケミストリーシンポジウム つながり醸成企画-未来を拓く創薬技術- 「タンパク質分解」 2023)
ｍore...
Education (2)：
  • 1998 - 2003 Hokkaido University
  • 1994 - 1998 Hokkaido University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • PhD (Hokkaido University)
Work history (11)：
  • 2024/04 - 現在 Graduate School of Pharmaceutical Sciences, The University of Tokyo Protein Dynamics Professor
  • 2023/04 - 現在 Tokyo Metropolitan Institute of Medical Science
  • 2023/04 - 現在 The Institute of Medical Science, The University of Tokyo Division of Protein Metabolism, Department of Basic Medical Sciences Professor
  • 2021/04 - 現在 Graduate School of Frontier Sciences, The University of Tokyo Department of Computational Biology and Medical Sciences
  • 2020/04 - 2023/03 Tokyo Metropolitan Institute of Medical Science
Show all
Awards (3)：
  • 2022/04 - 科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)
  • 2014/10 - 日本生化学会奨励賞
  • 2013/04 - 科学技術分野の文部科学大臣表彰 若手科学者賞
Association Membership(s) (5)：
ゲノム創薬創発フォーラム ,  Japanese Proteome Society ,  Japan Society for Cell Biology ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM