Ochiai Kyoko

オチアイキョウコ | Ochiai Kyoko

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.biochem.med.tohoku.ac.jp/members/index.html

Research field (2)： Immunology , Medical biochemistry

Research keywords (7)： Chromatin regulation , B細胞分化制御 , Signaling pathway , Gene regulatory network , Epigenetics , Transcription factor , Differentiation

Research theme for competitive and other funds (6)：

2020 - 2025 Development of anti-cancer strategy by exploiting BACH1 addiction
2020 - 2023 多発性骨髄腫で転写因子IKAROSの不安定化を促進する新規化合物の開発
2016 - 2018 選択的遺伝子領域の動的ヘテロクロマチン化誘導機構
2016 - 2018 Orchestration of memory B cell differentiation controlled by the regulation of IRF4 protein degradation
2013 - 2015 エピゲノム制御によるDNA損傷修復機構と細胞分化

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Papers (28)：

Kyoko Ochiai, Hiroki Shima, Toru Tamahara, Nao Sugie, Ryo Funayama, Keiko Nakayama, Tomohiro Kurosaki, Kazuhiko Igarashi. Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions. The EMBO journal. 2024
Kyoko Ochiai, Kazuhiko Igarashi. Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies. International immunology. 2022
Liang Liu, Mitsuyo Matsumoto, Miki Matsui-Watanabe, Kyoko Ochiai, Bert K K Callens, Long Chi Nguyen, Yushi Kozuki, Miho Tanaka, Hironari Nishizawa, Kazuhiko Igarashi. BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin. Antioxidants (Basel, Switzerland). 2022. 11. 8
Kyoko Ochiai, Hiroki Shima, Tsuyoshi Ikura, Marissa C Franke, Evelyn P Sievert, Roger Sciammas, Kazuhiko Igarashi. Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins. STAR protocols. 2021. 2. 3. 100633-100633
Kyoko Ochiai, Mari Yamaoka, Amrutha Swaminathan, Hiroki Shima, Hitoshi Hiura, Mitsuyo Matsumoto, Daisuke Kurotaki, Jun Nakabayashi, Ryo Funayama, Keiko Nakayama, et al. Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. Cell reports. 2020. 33. 12. 108517-108517

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MISC (14)：

落合恭子. IRF4によって統御されるB細胞-形質細胞分化の遺伝子発現ネットワーク. 臨床免疫・アレルギー科. 2019. 71. 3. 1-7
落合恭子. B細胞内のシグナル伝達機構(第7回) IRF4によるB細胞分化制御. 炎症と免疫. 2016. 24. 3. 249-252
落合恭子. 転写因子のBifunctional機能決定の分子機構解明. 上原記念生命科学財団研究報告集. 2015. 29. 1-3
落合恭子. B細胞における転写因子IRF4の濃度依存的な細胞成熟と分化の分子メカニズム. 血液内科. 2014. 68. 5. 712-718
玉原亨, 佐藤好宏, 落合恭子, 五十嵐和彦. 転写因子Bach2はmTORによって制御される. 日本分子生物学会年会プログラム・要旨集(Web). 2014. 37th. 2P-0731 (WEB ONLY)

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Lectures and oral presentations (8)：

転写因子とクロマチン制御因子による細胞分化制御の遺伝子発現ネットワーク
(The 42th Annual Meeting of the Molecular Biology Society of Japan 2019)
転写因子結合DNAモチーフの多様性が制御する細胞分化
(The 41th Annual Meeting of the Molecular Biology Society of Japan 2018)
The diversity of IRF4 DNA binding motifs governs cell fate during plasma cell differentiation
(7th Meeting of the Asian Forum of Chromosome and Chromatin Biology 2018)
Gene regulatory networks of B-to-plasma cell differentiation orchestrated by IRF4 and its partner transcription factors
(The 46th Annual Meeting of the Japanese Society for Immunology 2017)
Gene Regulatory Networks Composed by Transcription Factors Orchestrate Plasma Cell Differentiation
(The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Research and Disease 2017)

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Education (2)：

2002 - 2007 Hiroshima University
1996 - 2002 Hiroshima University Faculty of Dentistry

Professional career (1)：

Ph.D (Hiroshima University)

Work history (4)：

2021/07 - 現在東北大学プロミネントリサーチフェロー
2011 - 現在東北大学大学院医学系研究科生物化学分野助教
2007 - 2011 University of Chicago Molecular Genetics and Cell Biology Research associate
2007 - 東北大学大学院医学系研究科生物化学分野研究支援者

Awards (1)：

2021/07 - 東北大学東北大学プロミネントリサーチフェロー

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