Ito Yoshinaga

イトウヨシナガ | Ito Yoshinaga

Affiliation and department：
Homepage URL (2)： https://www.infront.kyoto-u.ac.jp/laboratory/lab21/ , https://www.infront.kyoto-u.ac.jp/en/laboratory/lab21/

Research field (3)： Tumor diagnostics and therapeutics , Allergies and connective tissue disease , Immunology

Research theme for competitive and other funds (4)：

2022 - 2024 新規抵抗性経路の網羅的同定と解除による免疫治療抵抗性癌の克服と、分子機序の解明
2012 - 2015 Identification of autoantigens recognized by pathogenic T cells in autoimmune arthritis
2008 - 2012 Molecular basis of the function and generation of Foxp3-expressing regulatory T cells
2006 - 2008 Analysis of pathophysiology and novel therapeutic approach for rheumatic diseases by arthritis-regulated proteins

Papers (26)：

Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y Juan, Jason W Pyrdol, Oleksandr Kyrysyuk, John G Doench, X Shirley Liu, Kai W Wucherpfennig. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines. Cancer discovery. 2023. 13. 5. 1186-1209
Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, et al. Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease. The Journal of experimental medicine. 2023. 220. 2
Sushil Kumar, Zexian Zeng, Archis Bagati, Rong En Tay, Lionel A Sanz, Stella R Hartono, Yoshinaga Ito, Fieda Abderazzaq, Elodie Hatchi, Peng Jiang, et al. CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. Cancer discovery. 2021. 11. 8. 2050-2071
Nathan D Mathewson, Orr Ashenberg, Itay Tirosh, Simon Gritsch, Elizabeth M Perez, Sascha Marx, Livnat Jerby-Arnon, Rony Chanoch-Myers, Toshiro Hara, Alyssa R Richman, et al. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021. 184. 5. 1281-1298
Rong En Tay, Olamide Olawoyin, Paloma Cejas, Yingtian Xie, Clifford A Meyer, Yoshinaga Ito, Qing Yu Weng, David E Fisher, Henry W Long, Myles Brown, et al. Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. The Journal of experimental medicine. 2020. 217. 7

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MISC (26)：

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Lectures and oral presentations (10)：

自己免疫疾患惹起性T細胞の標的自己抗原の同定
(RA Biologic Conference in 広島 2015)
自己免疫疾患惹起性T細胞の標的自己抗原の同定
(T-Cell Educational セミナー 2015)
T細胞はRPL23Aを標的自己抗原として関節炎を起こす
(第一回病因研究会別府シンポジウム 2015)
Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene
(1st Bio-Rheumatology International Congress/8th GARN Meeting Tokyo 2011)
II型コラーゲン誘発性関節炎(CIA)局所におけるIL-17分泌細胞の解析
(日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 2008)

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Education (2)：

Work history (8)：

2022/04 - 現在京都大学医生物学研究所再生組織構築研究部門病因免疫学分野教授
2020/05 - 2022/03 Harvard Medical School Instructor
2015/04 - 2020/04 Harvard Medical School Department of Immunology Research Fellow
2011/04 - 2015/03 京都大学再生医科学研究所生体機能調節学分野助教
2009/04 - 2011/03 京都大学再生医科学研究所生体機能調節学分野研究員

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Awards (1)：

Association Membership(s) (3)：

American Association for Cancer Research , 日本リウマチ学会 , 日本免疫学会

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