Takeuchi Toshihide

タケウチトシヒデ | Takeuchi Toshihide

Affiliation and department：
Job title： Associate Professor

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (9)：

2022 - 2025 エクソソームによるタンパク質クリアランス機構の解明と病的意義
2018 - 2021 Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasis
2016 - 2019 Investigation of the role of exosome-mediated maintenance of proteostasis in neurodegenerative diseases.
2015 - 2018 New strategy for intracellular delivery of biomacropharmaceuticals
2014 - 2018 Development of molecular therapy for polyglutamine diseases by reverse structure-based drug design

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Papers (75)：

Yoshinobu Takakura, Rikinari Hanayama, Kazunari Akiyoshi, Shiroh Futaki, Kyoko Hida, Takanori Ichiki, Akiko Ishii-Watabe, Masahiko Kuroda, Kazushige Maki, Yasuo Miura, et al. Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles. Pharmaceutical research. 2024
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, et al. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. Acta Neuropathologica Communications. 2024. 12. 1
武内敏秀, 前田和宏, 丁欣, 大江由佳子, 武田明子, 井上真奈, 長野清一, 藤原健志, 松田誠司, 石垣診祐, et al. TDP-43を標的とした核酸医薬はALS/FTDマウスに対して持続的な治療効果を発揮する. Dementia Japan. 2023. 37. 4. 708-708
Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, et al. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice. Molecular therapy. Nucleic acids. 2023. 31. 353-366
Toshihide Takeuchi, Yoshitaka Nagai. Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics. Neurochemistry International. 2022. 157. 105357-105357

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MISC (31)：

上山盛夫, 上山盛夫, 上山盛夫, 石黒太郎, 小澤大作, 小澤大作, 杉木俊彦, 石黒亮, 徳田栄一, 今野卓哉, et al. ショウジョウバエモデルによるC9orf72関連ALS/FTDの病態解明. 日本臨床ストレス応答学会大会抄録集. 2021. 15th
Toshihide Takeuchi. Non-cell autonomous maintenance of proteostasis by molecular chaperones and its molecular mechanism. Biological and Pharmaceutical Bulletin. 2018. 41. 6. 843-849
Non-cell autonomous maintenance of protein homeostasis by exosomal chaperone transmission contributes to therapeutic effects on polyglutamine disease models. 2016. 30. 3. 368-376
M. Akishiba, T. Takeuchi, Y. Kawaguchi, K. Sakamoto, I. Nakase, S. Futaki. DEVELOPMENT OF PEPTIDE TOOLS FOR INTRACELLULAR DELIVERY OF ANTIBODIES. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S106-S106
S. Futaki, Y. Kawaguchi, T. Takeuchi, K. Kuwata. PHOTOCROSSLINKING APPROACHES TO IDENTIFY CELLULAR-UPTAKE RECEPTORS OF ARGININE-RICH CELL-PENETRATING PEPTIDES. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S48-S48

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Patents (1)：

Professional career (1)：

Work history (3)：

Awards (1)：

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