Rchr
J-GLOBAL ID：201401053626032545
Update date: Feb. 13, 2024
Takeuchi Toshihide
タケウチ トシヒデ | Takeuchi Toshihide
Affiliation and department：
Job title：
Associate Professor
Research field (1)：
Clinical pharmacy
Research theme for competitive and other funds (9)：
- 2022 - 2025 エクソソームによるタンパク質クリアランス機構の解明と病的意義
- 2018 - 2021 Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasis
- 2016 - 2019 Investigation of the role of exosome-mediated maintenance of proteostasis in neurodegenerative diseases.
- 2015 - 2018 New strategy for intracellular delivery of biomacropharmaceuticals
- 2014 - 2018 Development of molecular therapy for polyglutamine diseases by reverse structure-based drug design
- 2013 - 2015 細胞膜タンパク質のオリゴマー形成制御法の開発とシンデカンの機能解析
- 2011 - 2012 逆ドラッグデザインアプローチによる合理的なポリグルタミン病分子治療薬の開発
- 2011 - 2012 凝集阻害ペプチドQBP1の脳内デリバリー法の開発とポリグルタミン病の分子治療
- 2005 - 2008 細胞内薬物送達の制御を目指した新規構造スイッチング型膜透過ペプチドの設計と開発
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Papers (73)：
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Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, et al. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. Acta Neuropathologica Communications. 2024. 12. 1
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Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, et al. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice. Molecular therapy. Nucleic acids. 2023. 31. 353-366
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Toshihide Takeuchi, Yoshitaka Nagai. Emerging roles of extracellular vesicles in polyglutamine diseases: Mutant protein transmission, therapeutic potential, and diagnostics. Neurochemistry International. 2022. 157. 105357-105357
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Xiaoman Zhang, Toshihide Takeuchi, Akiko Takeda, Hideki Mochizuki, Yoshitaka Nagai. Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions. PLOS ONE. 2022. 17. 6. e0270634-e0270634
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Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, et al. Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease. Scientific reports. 2022. 12. 1. 351-351
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MISC (31)：
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上山盛夫, 上山盛夫, 上山盛夫, 石黒太郎, 小澤大作, 小澤大作, 杉木俊彦, 石黒亮, 徳田栄一, 今野卓哉, et al. ショウジョウバエモデルによるC9orf72関連ALS/FTDの病態解明. 日本臨床ストレス応答学会大会抄録集. 2021. 15th
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Toshihide Takeuchi. Non-cell autonomous maintenance of proteostasis by molecular chaperones and its molecular mechanism. Biological and Pharmaceutical Bulletin. 2018. 41. 6. 843-849
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Non-cell autonomous maintenance of protein homeostasis by exosomal chaperone transmission contributes to therapeutic effects on polyglutamine disease models. 2016. 30. 3. 368-376
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M. Akishiba, T. Takeuchi, Y. Kawaguchi, K. Sakamoto, I. Nakase, S. Futaki. DEVELOPMENT OF PEPTIDE TOOLS FOR INTRACELLULAR DELIVERY OF ANTIBODIES. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S106-S106
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S. Futaki, Y. Kawaguchi, T. Takeuchi, K. Kuwata. PHOTOCROSSLINKING APPROACHES TO IDENTIFY CELLULAR-UPTAKE RECEPTORS OF ARGININE-RICH CELL-PENETRATING PEPTIDES. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S48-S48
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Patents (1)：
Professional career (1)：
Work history (3)：
- 2021/01 - 現在 Kindai University
- 2016/04 - 2020/12 Osaka University
- 2013/04 - 2016/03 Kyoto University Institute for Chemical Research
Awards (1)：
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