Art

J-GLOBAL ID：201802270536906994   Reference number：18A1061715

Non-cell Autonomous Maintenance of Proteostasis by Molecular Chaperones and Its Molecular Mechanism

分子シャペロンによるタンパク質恒常性の非細胞自律性維持とその分子機序

Author (2)： Takeuchi Toshihide (Department of Neurotherapeutics, Osaka University Graduate School of Medicine) ,  Takeuchi Toshihide (JST, PRESTO)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 6  Page： 843-849(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *chaperone protein ,...
Semi thesaurus term： *タンパク質恒常性 ,...

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Author keywords (10)： molecular chaperone ,  proteostasis ,  exosome ,  non-cell autonomous ,  polyglutamine ,  molecular chaperone ,  proteostasis ,  exosome ,  non-cell autonomous ,  polyglutamine

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Reference (48)：

• 1) Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature, 475, 324-332 (2011).
• 2) Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol., 11, 545-555 (2010).
• 3) Popiel HA, Takeuchi T, Fujita H, Yamamoto K, Ito C, Yamane H, Muramatsu S, Toda T, Wada K, Nagai Y. Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism. PLOS ONE, 7, e51069 (2012).
• 4) Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Futaki S, Wada K, Nagai Y. Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level. Proc. Natl. Acad. Sci. U.S.A., 112, E2497-E2506 (2015).
• 5) Sprang GK, Brown IR. Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization. Brain Res., 427, 89-93 (1987).

Terms in the title (6)： 分子シャペロン ,  タンパク質 ,  恒常性 ,  細胞 ,  自律性 ,  分子機序