KIMURA HIROAKI

キムラヒロアキ | KIMURA HIROAKI

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/70593622.ja.html

Research field (5)： Pharmaceuticals - health and biochemistry , Allergies and connective tissue disease , Immunology , Immunology , Metabolism and endocrinology

Research keywords (8)： hyoithyroidism , inflammation , 脂質代謝 , 血糖値コントロール , mycobacterial infection , autoimmune diseases , メタボリック症候群 , 免疫プロテアソーム

Research theme for competitive and other funds (17)：

2020 - 2023 Role of the immunoproteasome in nonalcoholic steatohepatitis
2018 - 2022 Neutrophils in inflammatory response induced by lipid crystals
2018 - 2022 Role of ARIH2 in the inflammasome-related cardiovascular disease
2016 - 2020 Role of adapter molecule ASC independent of inflammasome
2017 - 2020 新規治療法の開発を目指した糖・脂質代謝における免役プロテアソームの役割の解明

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Papers (98)：

Hidefumi Inaba, Shuhei Morita, Daisuke Kosugi, Yuki Asai, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Yuki Yamamoto, Masatoshi Jinnin, et al. Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors. Frontiers in immunology. 2023. 14. 1165004-1165004
Hidefumi Inaba, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Takakazu Sugita, Yuki Yamamoto, Masatoshi Jinnin, Hiroaki Kimura, Tomoko Kobayashi, et al. Human Leukocyte Antigens and Biomarkers in Type 1 Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors. Endocrinology and Metabolism. 2022. 37. 1. 84-95
Yasuyuki Shiraishi, Atsushi Kimura, Hiroaki Kimura, Tsukasa Ohmori, Masafumi Takahashi, Katsushi Takeshita. Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2021. 26. 3. 487-493
Sachiko Watanabe, Fumitake Usui-Kawanishi, Takanori Komada, Tadayoshi Karasawa, Ryo Kamata, Naoya Yamada, Hiroaki Kimura, Katsuya Dezaki, Tsukasa Ohmori, Masafumi Takahashi. ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome. Biochemical and biophysical research communications. 2020. 531. 2. 125-132
Homare Ito, Hiroaki Kimura, Tadayoshi Karasawa, Shu Hisata, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, et al. NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury. Journal of immunology (Baltimore, Md. : 1950). 2020. 205. 5. 1393-1405

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MISC (18)：

木村博昭, 木村博昭, 唐澤直義, 駒田敬則, 鎌田諒, 笠原忠, 高橋将文. 脂肪細胞分化における免疫プロテアソームの役割. 日本薬学会九州支部大会講演要旨集. 2019. 36th
Homare Ito, Yoshiyuki Inoue, Ai Sadatomo, Naoya Yamada, Ryo Kamata, Sachiko Watanabe, Tadayoshi Karasawa, Hiroaki Kimura, Yasunaru Sakuma, Hisanaga Horie, et al. NLRP3 INFLAMMASOMES CONTRIBUTE TO INFLAMMATION AND REGENERATION IN RADIATION-INDUCED ENTERITIS. GASTROENTEROLOGY. 2018. 154. 6. S497-S497
木村博昭, 中村潤, 渡邊幸子, 唐澤直義, 鎌田涼, 笠原忠, 三浦典子, 大野尚仁, 高橋将文. CAWS誘導川崎病様マウス血管炎のIL-10による病態抑制効果. 日本薬学会年会要旨集. 2018. 138年会. 4. 70-70
鎌田諒, 川島晃, 唐澤直義, 渡邊幸子, 木村博昭, 高橋将文. E3ユビキチンリガーゼARIH2によるNLRP3インフラマソーム制御機構の解明. 脈管学(Web). 2018. 58. supplement. S152(J-STAGE)
Hiroaki Kimura, Tadayoshi Karasawa, Sachiko Watanabe, Koichi Suzuki, Patrizio Caturegli, Masafumi Takahashi. Contribution of the immunoproteasome to the inflammatory phenotyope observed in obese mice. JOURNAL OF IMMUNOLOGY. 2017. 198. 1

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Education (2)：

1992 - 1998 Nagoya City University Graduate School of Pharmaceutical Sciences
1988 - 1992 Nagoya City University Medicin Medicin

Professional career (1)：

Ph.D. (Nagoya City University)

Work history (5)：

2019/04 - 現在 Kyushu University of Health and Welfare School of Pharmaceutical Sciences, Department of Pharmaceutical Sciences
2010/06 - 2019/03 Jichi Medical University School of Medicine
2008/07 - 2010/05 The Johns Hopkins Medical Institutions Dept of Pathology research associate
2001/07 - 2008/06 The Johns Hopkins Medical Institutions Dept of Pathology postdoctoral fellow
1998/05 - 2001/06 National Institute of Infectious Diseases Leprosy Research Center

Awards (5)：

2016/10 - 自治医科大学自治医大優秀論文賞
2010 - 日本甲状腺学会基礎医学研究助成受賞
2009 - Asia-Oceania Thyroid association Young Investigator Award
2009 - 日本甲状腺学会若手奨励賞
2008/07 - American Thyroid Association ATA grants 2008

Association Membership(s) (7)：

JAPAN SOCIETY FOR THE STUDY OF OBESITY , THE PHARMACEUTICAL SOCIETY OF JAPAN , American Thyroid Association , The Endocrine Society , THE JAPANAESE SOCIETY OF INFLAMMATION AND REGENERATION , 日本甲状腺学会 , THE JAPAN ENDOCRINE SOCIETY

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