Rchr
J-GLOBAL ID:201401072103921464
Update date: Apr. 04, 2024
Karasawa Tadayoshi
カラサワ タダヨシ | Karasawa Tadayoshi
Affiliation and department:
Homepage URL (1):
http://kaken.nii.ac.jp/d/r/60631893.ja.html
Research field (2):
Cell biology
, Metabolism and endocrinology
Research keywords (7):
凝集体
, Regulated cell death
, 脂肪酸
, リポタンパク質
, 動脈硬化
, 脂質代謝
, 炎症
Research theme for competitive and other funds (11):
- 2021 - 2024 Role and Mechanism of a novel E3 ligase ARIH2 in Cardiovascular Disease
- 2021 - 2024 動脈硬化病変におけるカスパーゼ11依存的パイロトーシスの役割の解明
- 2019 - 2022 Mechanism of NLRP3 inflammasome in CAWS-induced vasculitis
- 2018 - 2022 Role of ARIH2 in the inflammasome-related cardiovascular disease
- 2016 - 2020 Role of adapter molecule ASC independent of inflammasome
- 2016 - 2019 The study about inflammasome regulation system by protein degradation
- 2018 - 脂質結晶により誘導される好中球性炎症の分子基盤の解明
- 2015 - 2018 Molecular mechanisms underlying inflammasome-mediated cardiovascular disease
- 2016 - 2018 動脈硬化での炎症の遷延におけるインフラマソームの役割の解明
- 2014 - 2016 Regulation of NLRP3 inflammasome by modulation of lipid metabolisms
- 2012 - 2014 インフラマソームの生活習慣病の病態における役割の解明とその新規制御法の確立
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Papers (74):
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Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, et al. Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. Nature communications. 2024. 15. 1. 2195-2195
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Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai. Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
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Hazuki Tanaka, Ren Ozawa, Yuka Henmi, Manabu Hosoda, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna. Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages. Reproductive biology. 2024. 24. 1. 100857-100857
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Tadayoshi Karasawa, Takanori Komada, Chintogtokh Baatarjav, Emi Aizawa, Yoshiko Mizushina, Kenta Fujimura, Yoshitaka Gunji, Satoko Komori, Hidetoshi Aizawa, Cantona Billton Jing Tao, et al. Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice. Biochemical and biophysical research communications. 2023. 686. 149158-149158
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Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, et al. NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy. Journal of molecular and cellular cardiology. 2023. 180. 58-68
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MISC (15):
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木村博昭, 木村博昭, 唐澤直義, 駒田敬則, 鎌田諒, 笠原忠, 高橋将文. 脂肪細胞分化における免疫プロテアソームの役割. 日本薬学会九州支部大会講演要旨集. 2019. 36th
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Homare Ito, Yoshiyuki Inoue, Ai Sadatomo, Naoya Yamada, Ryo Kamata, Sachiko Watanabe, Tadayoshi Karasawa, Hiroaki Kimura, Yasunaru Sakuma, Hisanaga Horie, et al. NLRP3 INFLAMMASOMES CONTRIBUTE TO INFLAMMATION AND REGENERATION IN RADIATION-INDUCED ENTERITIS. GASTROENTEROLOGY. 2018. 154. 6. S497-S497
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木村 博昭, 中村 潤, 渡邊 幸子, 唐澤 直義, 鎌田 涼, 笠原 忠, 三浦 典子, 大野 尚仁, 高橋 将文. CAWS誘導川崎病様マウス血管炎のIL-10による病態抑制効果. 日本薬学会年会要旨集. 2018. 138年会. 4. 70-70
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鎌田諒, 川島晃, 唐澤直義, 渡邊幸子, 木村博昭, 高橋将文. E3ユビキチンリガーゼARIH2によるNLRP3インフラマソーム制御機構の解明. 脈管学(Web). 2018. 58. supplement. S152(J-STAGE)
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Kyoko Honne, Masahiro Iwamoto, Shunichiro Hanai, Satoshi Machida, Hitoshi Sekiya, Reina Tsuda, Tatsuhiko Ozawa, Tadayoshi Karasawa, Atsushi Muraguchi, Masafumi Takahashi, et al. Immunocompetent Cells Expressing Citrullinated Proteins in Joint Synovium of Osteoarthritis and Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY. 2017. 69
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Patents (1):
Education (3):
- 2008 - 2012 University of Tsukuba
- 2006 - 2008 University of Tsukuba
- 2002 - 2006 University of Tsukuba
Work history (3):
- 2020/04 - 現在 自治医科大学 分子病態治療研究センター 炎症・免疫研究部 講師
- 2014/04 - 現在 Jichi Medical University School of Medicine
- 2012/04 - 2014/03 Jichi Medical University School of Medicine
Association Membership(s) (4):
JAPAN ATHEROSCLEROSIS SOCIETY
, 日本脂質生化学会
, 日本分子生物学会
, 日本Cell death学会
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