Rchr

J-GLOBAL ID：201501018578504160 Update date: Mar. 09, 2023

HORI Kazuya

ホリカズヤ | HORI Kazuya

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Tumor biology

Research theme for competitive and other funds (10)：

2021 - 2024 転写調節CDK阻害薬による大腸癌の癌幹細胞性の抑制
2018 - 2021 Intestinal mucosal barrier by homeobox protein CDX2
2018 - 2021 ホメオボックス転写因子CDXsによる大腸癌の癌幹細胞性関連遺伝子の発現抑制機構
2016 - 2018 Mechanism of suppression of Notch signaling by CDX1 and CDX2 in colon cancer cells
2017 - 大腸癌細胞の癌幹細胞性の制御機構の解析

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Papers (15)：

Akari Nitta, Kazuya Hori, Isei Tanida, Ayumi Igarashi, Yasuyo Deyama, Takashi Ueno, Eiki Kominami, Manabu Sugai, Koji Aoki. Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S. Biochemical and biophysical research communications. 2019. 508. 2. 521-526
Tao Xu, Sung-Soo Park, Benedetto Daniele Giaimo, Daniel Hall, Francesca Ferrante, Diana M Ho, Kazuya Hori, Lucas Anhezini, Iris Ertl, Marek Bartkuhn, et al. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. The EMBO journal. 2017. 36. 21. 3232-3249
Kazuya Hori, Anindya Sen, Spyros Artavanis-Tsakonas. Genetic circuitry modulating notch signals through endosomal trafficking. Methods in enzymology. 2014. 534. 283-99
K G Guruharsha, Kazuya Hori, Robert A Obar, Spyros Artavanis-Tsakonas. Proteomic analysis of the Notch interactome. Methods in molecular biology (Clifton, N.J.). 2014. 1187. 181-92
Anindya Sen, Douglas N Dimlich, K G Guruharsha, Mark W Kankel, Kazuya Hori, Takakazu Yokokura, Sophie Brachat, Delwood Richardson, Joseph Loureiro, Rajeev Sivasankaran, et al. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2013. 110. 26. E2371-80

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MISC (2)：

Lectures and oral presentations (54)：

Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
(Looking to the future of Developmental Cell Biology Symposium 2018)
Suppression of intestinal cancer stemness and malignant progression by homeoproteins CDX1 and CDX2
(日本薬学会北陸支部第129回例会 2017)
Enhanced intestinal mucosal barrier function by homeoprotein CDX2 through autophagy activation
(第39回日本分子生物学会年会 2016)
Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
(第39回日本分子生物学会年会 2016)
Blocking intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
(第3回北陸エピジェネティクス研究会 2016)

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Education (3)：

2002 - 2005 東京理科大学大学院基礎工学研究科生物工学専攻博士後期課程
2000 - 2002 東京理科大学大学院基礎工学研究科生物工学専攻修士課程
1996 - 2000 東京理科大学基礎工学部生物工学科

Work history (6)：

2014/10 - 現在福井大学学術研究院医学系部門薬理学分野助教
2009/04 - 2014/09 Harvard Medical School Postdoctoral fellow
2007/04 - 2009/03 ハーバード大学医学大学院日本学術振興会・海外特別研究員
2006/04 - 2007/03 Harvard Medical School Postdoctoral fellow
2004/04 - 2006/03 東京理科大学大学院日本学術振興会・特別研究員

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Awards (2)：

2013/12 - 第36回日本分子生物学会海外ポスドク招聘企画
2011/11 - 第6回Notch研究会ポスター賞

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