Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences Division of Bio-Pharmaceutical Science Molecular Pharmaceutics
About Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences Division of Bio-Pharmaceutical Science Molecular Pharmaceutics
Research field (5):
Hygiene and public health (laboratory)
, Pathobiochemistry
, Medical biochemistry
, Pharmaceuticals - health and biochemistry
, Immunology
2018 - 2021 Elucidation of balancing mechanisms of death receptor signaling mediated by STK11
2019 - 2021 NLRP3インフラマソーム阻害薬の開発
2016 - 2020 Development of efficient and versatile method for inducing neuronal differentiation with temperature-controlled repeated thermal stimulation (TRTS)
2019 - 2020 癌抑制因子STK11/LKB1による薬剤性パータナトス抑制機構の解明
2019 - 2020 パータナトス阻害剤の探索
2013 - 2016 Elucidation of the phospho-dependent mechanisms of apoptosis induction
2008 - 2013 Drug development by the molecular mechanism-based analysis of stress signaling
2008 - 2009 小胞体品質管理におけるタンパク質分解の新規分子メカニズムの解明
2008 - 2008 口腔疾患に関わるストレスシグナル解明への遺伝学的アプローチ
2007 - 2008 Functional analysis of ASK2, a novel stress-responsive kinase, in carcinogenesis of oral squamous cell carcinomas
2006 - 2007 異常蛋白質蓄積によるASK1シグナルを介した神経変性細胞死の分子病態の解明
2006 - 2007 活性酸素種によるASK1活性化制御機構の解明
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Papers (67):
Yusuke Hirata, Yuya Nakata, Hiromu Komatsu, Yuki Kodoh, Miki Takahashi, Soma Taguchi, Takuya Noguchi, Atsushi Matsuzawa. Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1. Free Radical Biology and Medicine. 2024
Tomohiro Kagi, Aya Inoue, Takuya Noguchi, Wakana Suzuki, Saya Takano, Kohei Otani, Rio Naganuma, Yuto Sekiguchi, Yusuke Hirata, Sawako Shindo, et al. The NLRP3 Inflammasome Is a Major Cause of Acute Renal Failure Induced by Polypeptide Antibiotics. The Journal of Immunology. 2024
Takumi Yokosawa, Sayoko Miyagawa, Wakana Suzuki, Yuki Nada, Yusuke Hirata, TAKUYA Noguchi, Atsushi Matsuzawa. The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1. Cells. 2024. 13. 8. 687
Shuhei Hamano, Takuya Noguchi, Yukino Asai, Ryo Ito, Ryuto Komatsu, Tetsu Sato, Aya Inoue, Tomoe Maruyama, Tada-aki Kudo, Yusuke Hirata, et al. Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Cell Death Discovery. 2024. 10. 1. 74
Kanako Tominami, Tada-aki Kudo, TAKUYA Noguchi, Yohei Hayashi, You-Ran Luo, Takakuni Tanaka, Ayumu Matsushita, Satoshi Izumi, Hajime Sato, Keiko Gengyo-Ando, et al. Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review. International Journal of Molecular Sciences. 2024. 25. 2. 772