OZAWA Manabu

オザワマナブ | OZAWA Manabu

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/80608787.ja.html

Research field (4)： Laboratory animal science , Developmental biology , Clinical pharmacy , Physiology

Research keywords (9)： alternative splicing , Sertoli cells , spermatogonial stem cells , testis , spermatogenesis , epigenetics , meiosis , sperm , germ cells

Research theme for competitive and other funds (8)：

2024 - 2026 セルトリ細胞はどのような分子経路を介して精細胞の減数分裂を制御するのか?
2021 - 2026 Development of male infertile model mice by genome editing and comprehensive study of fertilization
2020 - 2023 精細胞の分化を制御するセルトリ細胞の機能的役割の解明
2017 - 2021 Histone modifications in regulating the balance between self-renewal and differentiation of spermatogonia
2016 - 2021 Advanced Animal Model Support

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Papers (86)：

Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashi. Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024. 27. 2. 108997-108997
Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, et al. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice. Communications Biology. 2024. 7. 1
Yu Ishikawa-Yamauchi, Chihiro Emori, Hideto Mori, Tsutomu Endo, Kiyonori Kobayashi, Yuji Watanabe, Hiroshi Sagara, Takeshi Nagata, Daisuke Motooka, Akinori Ninomiya, et al. Age-associated aberrations of cumulus-oocyte interaction and microfilamentous structure in the zona pellucida decline female fertility. bioRxiv. 2023
Manabu Ozawa, Hideto Mori, Tsutomu Endo, Yu Ishikawa-Yamauchi, Daisuke Motooka, Chihiro Emori, Masahiro Ikawa. Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice. iScience. 2023
Dan Li, Yoshikazu Johmura, Satoru Morimoto, Miyuki Doi, Keiko Nakanishi, Manabu Ozawa, Yuji Tsunekawa, Akane Inoue-Yamauchi, Hiroya Naruse, Takashi Matsukawa, et al. LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits. Nature aging. 2023

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MISC (31)：

小沢学, 川上絵里, 徳永暁憲, 坂本怜子, 吉田進昭. ヒストン脱メチル化酵素Kdm2aは精原細胞の自己複製と分化のバランスを調整する. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4T20L-10(3P0929)]
A. Q. Bonilla, U. Oliveira, M. Ozawa, E. M. Newsom, M. C. Lucy, P. J. Hansen. Developmental changes in thermoprotective actions of insulin-like growth factor-1 on the preimplantation bovine embryo (vol 332, pg 170, 2011). MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2015. 413. C. 248-248
Kyle B. Dobbs, Firdous A. Khan, Miki Sakatani, James I. Moss, Manabu Ozawa, Alan D. Ealy, Peter J. Hansen. Regulation of Pluripotency of Inner Cell Mass and Growth and Differentiation of Trophectoderm of the Bovine Embryo by Colony Stimulating Factor 2 (vol 89, pg 141, 2013). BIOLOGY OF REPRODUCTION. 2014. 91. 5
M. Ozawa, M. Sakatani, K. E. Hankowski, N. Terada, K. B. Dobbs, P. J. Hansen. Importance of culture conditions during the morula-to-blastocyst period on capacity of inner cell-mass cells of bovine blastocysts for establishment of self-renewing pluripotent cells (vol 78, pg 1243, 2012). THERIOGENOLOGY. 2014. 81. 7. 1004-1004
Manabu Ozawa. A novel method for purification of inner cell mass and trophectoderm cells from blastocysts using magnetic activated cell sorting (vol 95, pg 799, 2011). FERTILITY AND STERILITY. 2014. 101. 3. 884-884

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Education (2)：

1998 - 2003 University of Tsukuba
- 1998 University of Tsukuba

Professional career (1)：

博士(農学) (筑波大学)

Work history (6)：

2016/12 - 現在 The University of Tokyo The Institute of Medical Science
2011/01 - 2016/12 The University of Tokyo The Institute of Medical Science
2009/04 - 2011/01 University of Florida 日本学術振興会海外特別研究員
2008/01 - 2009/04 The University of Tokyo The Institute of Medical Science
2005/04 - 2008/01 農業生物資源研究所日本学術振興会 PD

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Awards (6)：

2021/09 - The Society for Reproduction and Development Outstanding Paper Award
2015 - 東京大学医科学研究所創立記念シンポジウムベストポスター賞
2014/08 - 高遠分子細胞生物学シンポジウム優秀ポスター賞
2013 - リバネス研究費アフィメトリクス・ジャパン賞
2009/09 - The Society for Reproduction and Development Outstanding Paper Award

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Association Membership(s) (4)：

日本実験動物学会 , Society for the Study of Reproduction , SOCIETY FOR REPRODUCTION AND DEVELOPMENT , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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