Aikawa Chihiro

アイカワチヒロ | Aikawa Chihiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Bacteriology

Research theme for competitive and other funds (16)：

2022 - 2025 A群レンサ球菌の金属輸送系を標的とした治療薬剤としての人工抗体の取得
2021 - 2024 A群レンサ球菌の分泌毒素Ngaの新規機能による宿主制御機構の解析
2020 - 2023 Involvement in the pathogenic mechanism of Streptococcus pyogenes-derived extracellular vesicles
2019 - 2022 Functional analysis of Beclin 1 regulating different stages during bacterial infection
2019 - 2022 Elucidation of the Rab regulatory network that induces bacterial species-specific xenophagy

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Papers (43)：

Risa Asano, Miyu Takeuchi, Makoto Nakakido, Sho Ito, Chihiro Aikawa, Takeshi Yokoyama, Akinobu Senoo, Go Ueno, Satoru Nagatoishi, Yoshikazu Tanaka, et al. Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA. Protein science : a publication of the Protein Society. 2024. 33. 6. e5017
Chihiro Aikawa, Akihide Shimizu, Makoto Nakakido, Kazunori Murase, Takashi Nozawa, Kouhei Tsumoto, Ichiro Nakagawa. Group A Streptococcus cation diffusion facilitator proteins contribute to immune evasion by regulating intracellular metal concentrations. Biochemical and biophysical research communications. 2023. 676. 141-148
Sandra Valenciano-Bellido, Jose M M Caaveiro, Makoto Nakakido, Daisuke Kuroda, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth. The Journal of biological chemistry. 2023. 104927-104927
Chihiro Aikawa, Kiyosumi Kawashima, Chihiro Fukuzaki, Makoto Nakakido, Kazunori Murase, Takashi Nozawa, Kouhei Tsumoto, Ichiro Nakagawa. Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection. Biochemical and biophysical research communications. 2021. 566. 177-183
Tsukushi Yamawaki, Makoto Nakakido, Kan Ujiie, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor. Biochemical and biophysical research communications. 2021. 565. 1-7

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MISC (10)：

Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa. TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. Nature communications. 2020. 11. 1. 770-770
竹内美結, 中木戸誠, 長門石曉, 河出来時, 相川知宏, 中川一路, 津本浩平, 津本浩平, 津本浩平. 化膿連鎖球菌の金属獲得蛋白質MtsAに対する機能阻害剤の探索. 日本生化学会大会(Web). 2020. 93rd
中木戸誠, 相川知宏, 長門石曉, 妹尾暁暢, 竹内美結, 星野将人, 下村拓矢, CAAVEIRO Jose M. M., 中川一路, 津本浩平, et al. Strategy to develop small molecule and antibody-based inhibitors relying on biophysical techniques. 日本細菌学雑誌(Web). 2020. 75. 1
中川一路, 相川知宏, 妹尾暁暢, 中木戸誠, 長門石暁, 津本浩平, 津本浩平. 分子間相互作用阻害に基づく菌種特異的な増殖阻害剤の開発. 日本生化学会大会(Web). 2019. 92nd
Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa. Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Frontiers in cellular and infection microbiology. 2019. 9. 398-398

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Lectures and oral presentations (1)：

CRISPR/Casシステム:微生物における新規機能とゲノム編集適用例
(日本乳酸菌学会2014年度秋期セミナー・酢酸菌研究会第6回研究集会合同シンポジウム 2014)

Professional career (1)：

博士 (東京大学)

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