Sachiko Machida

Research field (1)： Applied biochemistry

Research keywords (4)： advanced glycation end products , oxidized LDL , protein engineering , receptor

Papers (8)：

Miyuki Kumano-Kuramochi, Ken-Ichiro Tatematsu, Mayumi Ohnishi-Kameyama, Mari Maeda-Yamamoto, Toshiro Kobori, Hideki Sezutsu, Sachiko Machida. Co-expression of BirA with biotin bait achieves in vivo biotinylation of overexpressed stable N-glycosylated sRAGE in transgenic silkworms. SCIENTIFIC REPORTS. 2017. 7. 1. 356
Miyuki Kumano-Kuramochi, Takashi Fujimura, Shiro Komba, Mari Maeda-Yamamoto, Sachiko Machida. Screening, expression, and characterization of an anti-human oxidized low-density lipoprotein single-chain variable fragment. JOURNAL OF BIOSCIENCE AND BIOENGINEERING. 2016. 122. 3. 287-293
Miho Chikazawa, Takahiro Shibata, Yukinori Hatasa, Sayumi Hirose, Natsuki Otaki, Fumie Nakashima, Mika Ito, Sachiko Machida, Shoichi Maruyama, Koji Uchidat. Identification of C1q as a Binding Protein for Advanced Glycation End Products. BIOCHEMISTRY. 2016. 55. 3. 435-446
Kumano-Kuramochi M, Shimozu Y, Wakita C, Ohnishi-Kameyama M, Shibata T, Matsunaga S, Takano-Ishikawa Y, Watanabe J, Goto M, Xie Q, et al. Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. The Biochemical journal. 2012. 442. 1. 171-180
Takahiro Shibata, Yuuki Shimozu, Chika Wakita, Noriyuki Shibata, Makio Kobayashi, Sachiko Machida, Rina Kato, Hiroyuki Itabe, Xiaochun Zhu, Lawrence M. Sayre, et al. Lipid Peroxidation Modification of Protein Generates N-epsilon-(4-Oxononanoyl)lysine as a Pro-inflammatory Ligand. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. 286. 22. 19943-19957

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MISC (16)：

町田幸子, 小堀俊郎, 立松謙一郎, 瀬筒秀樹. 加齢性疾患の原因となる刺激性終末糖化産物(AGEs)の検出法の開発. バイオサイエンスとインダストリー. 2020. 78. 4. 308-311
町田幸子, 立松謙一郎, 倉持(熊野) みゆき, 小堀俊郎, 瀬筒秀樹. 遺伝子組換えカイコによるヒト終末糖化産物受容体の生産 (特集蚕業革命 : カイコが拓く新産業). 蚕糸・昆虫バイオテック. 2019. 88. 3. 161-165
町田幸子, 小堀俊郎, 倉持みゆき, 瀬筒秀樹, 立松謙一郎. 刺激性AGEs測定キット. 農研機構食品研究部門成果情報(Web). 2019. 2019
Recombinant protein production in the silk glands of transgenic silkworms. 2016. 74. 6. 501-504
廣瀬冴美, 日沖裕介, 中村哲彰, 宮下宙士, 近澤未歩, 柴田貴広, 町田幸子, 内田浩二. 自己抗体反応性ピロール化タンパク質と相互作用する血清タンパク質. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0461]-[1P0461]

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Patents (19)：

AGEsを検出するためのアッセイ系
Biotinlated oxidized LDL receptor and andanced glycated end product receptor produced using genetically engineered silkworm
Biotinlated oxidized LDL receptor and andanced glycated end product receptor produced using genetically engineered silkworm
遺伝子組換えカイコにより生産したビオチン化酸化LDL受容体・終末糖化産物受容体
Biotinlated oxidized LDL receptor and andanced glycated end product receptor produced using genetically engineered silkworm

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Education (1)：

- 1987 京都大学大学院農学研究科

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