Rchr
J-GLOBAL ID：201601004260315918   Update date: Oct. 09, 2024

Kon Ayana

コン アヤナ | Kon Ayana
Affiliation and department：
The University of Tokyo Division of Hematology and Tumor Biology, The Institute of Medical Science

About The University of Tokyo Division of Hematology and Tumor Biology, The Institute of Medical Science


Job title： Associate Professor / PI
Homepage URL  (1)： https://www.ims.u-tokyo.ac.jp/imsut/jp/lab/advancedclinicalresearch/page_00455.html
Research field  (2)： Tumor biology ,  Hematology and oncology
Research keywords  (7)： コヒーシン複合体 ,  造血幹細胞 ,  Myelodysplastic symdromes ,  急性骨髄性白血病 ,  molecular biology ,  RNA splicing ,  epigenetics
Research theme for competitive and other funds  (10)：
  • 2021 - 2024 Elucidating the mechanisms of clonal evolution of myeloid neoplasms with germline predisposition
  • 2019 - 2024 comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.
  • 2022 - 2024 DDX41変異前がん細胞と微小環境の相互作用に基づくクローン進化過程の理解と新たな治療標的の解明
  • 2020 - 2022 Elucidating the contribution of the order of mutation acquisition to the clonal evolution of cancer using single-cell sequencing
  • 2018 - 2021 Elucidating the molecular mechanisms underlying the clonal evolution of leukemic stem cells
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Papers (26)：
  • Atsushi Tanaka, Koutarou Nishimura, Wataru Saika, Ayana Kon, Yui Koike, Hiromi Tatsumi, June Takeda, Masaki Nomura, Weijia Zang, Manabu Nakayama, et al. SETBP1 is dispensable for normal and malignant hematopoiesis. Leukemia. 2023
  • Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, et al. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms. Blood. 2023. 141. 5. 534-549
  • June Takeda, Kenichi Yoshida, Masahiro M Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi, et al. Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia. Blood cancer discovery. 2022. 3. 5. 410-427
  • Keita Yamamoto, Susumu Goyama, Shuhei Asada, Takeshi Fujino, Taishi Yonezawa, Naru Sato, Reina Takeda, Akiho Tsuchiya, Tomofusa Fukuyama, Yosuke Tanaka, et al. A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells. Cell Reports. 2021. 36. 8. 109576-109576
  • Ayana Kon. Clonal evolution of myeloid malignancies. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2020. 61. 9. 1120-1129
ｍore...
MISC (66)：
  • Ayana Kon. Splicing factor mutations in hematological malignancies. 2023. 41. 13
  • 昆 彩奈. 【がんと慢性炎症】骨髄異形成症候群と慢性炎症. 別冊Bio Clinica: 慢性炎症と疾患. 2022. 11. 2. 37-41
  • 昆 彩奈. 血液疾患におけるBCOR遺伝子変異の意義. 血液内科. 2022. 85. 3. 384-389
  • 昆 彩奈, 中川 正宏, 片岡 圭亮, 垣内 伸之, 牧島 秀樹, 越智 陽太郎, 中山 学, 古関 明彦, 南谷 泰仁, 小川 誠司. 骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies). 日本癌学会総会記事. 2022. 81回. E-1066
  • Qi Xingxing, Yoshizatoi Tetuichi, 南谷 泰仁, Nakagawa Masahiro M., 森 拓人, 昆 彩奈, 依田 成玄, 越智 陽太郎, 竹田 淳恵, 佐伯 龍之介, et al. Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中). 日本癌学会総会記事. 2022. 81回. P-1255
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Lectures and oral presentations  (57)：
  • 骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)
    (日本癌学会総会記事 2022)
  • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
    (日本癌学会総会記事 2022)
  • Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中)
    (日本癌学会総会記事 2022)
  • 骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)
    (日本癌学会総会記事 2022)
  • ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes(和訳中)
    (日本血液学会学術集会 2021)
ｍore...
Education (2)：
  • 2011 - 2015 The University of Tokyo Graduate School of Medicine
  • 2001 - 2007 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (1)：
  • 医学博士 (東京大学)
Work history (9)：
  • 2024/05 - 現在 東京大学医科学研究所 先端医療研究センター 血液・腫瘍生物学分野 准教授 (分野長)
  • 2023/04 - 2024/04 Kyoto University, Graduate School of Medicine Department of Pathology and Tumor Biology
  • 2018/04 - 2023/03 Kyoto University Graduate School of Medicine
  • 2016/04 - 2018/03 Kyoto University Graduate School of Medicine
  • 2015/04 - 2016/03 日本学術振興会 特別研究員(PD)
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Committee career (2)：
  • 2023/04 - 現在 京都大学 環境管理専門委員会 有機廃液情報管理小委員会 全学委員
  • 2017/04 - 現在 京都大学 医学研究科動物実験施設運営委員会
Awards (8)：
  • 2023/07 - 日本血液学会 第13回JSH国際シンポジウム Best Symposium Award
  • 2018 - 日本癌学会 奨励賞
  • 2015 - 日本血液学会 奨励賞
  • 2015 - ISEH 44th Annual Scientific Meeting Travel Grant Award
  • 2015 - 20th Congress of EHA Travel Award
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Association Membership(s) (4)：
日本造血細胞移植学会 ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF HEMATOLOGY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE
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