Takemoto Hiroyasu

タケモトヒロヤス | Takemoto Hiroyasu

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://kpu-m.medchem.jp/index.html

Research field (2)： Biomaterials , Biomedical engineering

Research keywords (4)： nucleic acid , drug delivery system , biomaterials , polymer

Research theme for competitive and other funds (12)：

2024 - 2028 rational design of pH-responsive polyzwitterion for tumor-targeted drug vehicle
2023 - 2025 シェル分子内電離挙動の精密制御と被覆ナノ粒子のがん深部送達促進への展開
2018 - 2022 新規シェル、コア設計による次世代スマート機能型高分子ミセルの創製
2019 - 2021 細胞の固定結合のためのポリマーの開発
2018 - 2020 肌表面の微小環境を認識して健全な常在菌フローラを育成する機能性高分子の開発

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Papers (68)：

Masahiro Toyoda, Yutaka Miura, Motoaki Kobayashi, Masato Tsuda, Takahiro Nomoto, Yuto Honda, Hiroyuki Nakamura, Hiroyasu Takemoto, Nobuhiro Nishiyama. Synthesis and Optimization of Ethylenediamine-Based Zwitterion on Polymer Side Chain for Recognizing Narrow Tumorous pH Windows. Biomacromolecules. 2024
Motoki Naka, Tomohiro Umeno, Mika Shibuya, Yuto Yamaberi, Atsushi Ueda, Masakazu Tanaka, Hiroyasu Takemoto, Makoto Oba. Intracellular Delivery of Plasmid DNA Using Amphipathic Helical Cell-Penetrating Peptides Containing Dipropylglycine. Chemical and Pharmaceutical Bulletin. 2024. 72. 5. 512-517
Chengyuan Zhu, Hiroyasu Takemoto, Yuriko Higuchi, Fumiyoshi Yamashita. Programmed immobilization of living cells using independent click pairs. Biochemical and biophysical research communications. 2024. 699. 149556-149556
Keitaro Homma, Yutaka Miura, Motoaki Kobayashi, Wanphiwat Chintrakulchai, Masahiro Toyoda, Koichi Ogi, Junya Michinishi, Tomoyuki Ohtake, Yuto Honda, Takahiro Nomoto, et al. Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential. Science and technology of advanced materials. 2024. 25. 1. 2338785-2338785
Xin Shen, Anjaneyulu Dirisala, Masahiro Toyoda, Yao Xiao, Haochen Guo, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto, Yutaka Miura, Nobuhiro Nishiyama. pH-responsive polyzwitterion covered nanocarriers for DNA delivery. Journal of Controlled Release. 2023. 360. 928-939

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MISC (49)：

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Patents (35)：

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Books (6)：

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Lectures and oral presentations (9)：

生体内刺激応答性高分子の開発とがん送達への展開
(第11回 9大学化学会 2023)
Polyzwitterion that recognizes tumorous pH for effective tumor delivery of the coated materials
(VANJ Conference 2020 2020)
Polyzwitterion that recognizes cancerous environment for effective delivery of the coated nanomaterials to tumor tissues
(3rd GLowing Polymer Symposium in KANTO 2020)
Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue
(第77回日本癌学会学術総会 2018)
Bioresponsive Polyzwitterion that Recognizes Tumorous pH for a Construction of Tumor-targeted Carriers
(The 35th International Conference of Photopolymer Science and Technology (ICPST-35) 2018)

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Education (3)：

Professional career (1)：

Work history (4)：

2023/09 - 2023/12 Kochi University Faculty of Science and Technology
2023/04 - Kyoto Prefectural University of Medicine Graduate School of Medical Science
2021/01 - 2023/03 協和キリン株式会社
2013/04 - 2020/12 Tokyo Institute of Technology Institute of Innovative Research assistant professor

Committee career (4)：

Awards (5)：

Association Membership(s) (4)：

American Chemical Society , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE JAPANESE SOCIETY FOR BIOMATERIALS , THE SOCIETY OF POLYMER SCIENCE, JAPAN

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