Daisuke Yasuda

ヤスダダイスケ | Daisuke Yasuda

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://www.ompu.ac.jp/class/pharm/pmb.html

Research field (3)： Pharmaceuticals - chemistry and drug development , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (19)： Keap1 , PROTAC , アルツハイマー病 , ADMET , Epigenetics , Antiviral agent , Anticancer agents , Fluorescent probes , Parkinson's Disease , Nrf2 , Autophagy , ALS , Oxidative stress , Organic chemistry , Antioxidant , Medicinal chemistry , Medicinal Chemistry , Chemical biology , Click chemistry

Research theme for competitive and other funds (3)：

2023 - 2026 Development of Nrf2 modulators for enhancing chemotherapy sensitivity and reducing side effects in cancer treatment
2019 - 2022 Development of chemoresistance-overcoming agent targeting p62-Keap1-Nrf2 axis
2016 - 2018 生細胞内クリックケミストリー実行時の毒性を抑制する抗酸化剤の開発

Papers (16)：

Daiki Katagishi, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino, Tomoyuki Ohe. Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease. Bioorganic and Medicinal Chemistry Letters. 2023. 80. 129121-129121
Daisuke Yasuda*, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino, et al. Development of p62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer. Results in Chemistry. 2022. 4. 100609
Yasuhiro TateishiTomoyuki OheDaisuke, YasudaKyoko TakahashiShigeo NakamuraYasuhiro, KazukiTadahiko Mashino. Synthesis and Evaluation of Nevirapine Analogs to Study the Metabolic Activation of Nevirapine. Drug Metabolism and Pharmacokinetics. 2020. 35. 2. 238-243
Hideyuki Okano, Daisuke Yasuda, Koki Fujimori, Satoru Morimoto, Shinichi Takahashi. Ropinirole, a New ALS Drug Candidate Developed Using iPSCs. Trends in Pharmacological Sciences. 2020. 41. 2. 99-109
Yasuda D., Ohe T., Takahashi, K., Imamura, R., Kojima H., Okabe T., Ichimura Y., Komatsu M., Yamamoto M., Nagano T., et al. Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line. Free Radical Research. 2020. 54. 11-12. 859-871

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MISC (5)：

清川慎介, 安田大輔, 生長幸之助. 新たな機能性分子を合成する手法“クリックケミストリー”- 2022年ノーベル化学賞によせて. 医学のあゆみ. 2022. 283. 13. 1173-1175
Daisuke Yasuda. メディシナルケミストへ勧める「相分離メガネ」のかけ方. 2021. 57. 7. 667
YASUDA Daisuke, OBATA Rika, TAKAHASHI Kyoko, OHE Tomoyuki, MASHINO Tadahiko. Hit-to-Lead in Academia : Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2. YAKUGAKU ZASSHI. 2018. 138. 8. 1059-1065
中島真央, 安田大輔, 大江知之, 高橋恭子, 小松雅明, 一村義信, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, et al. 医薬品としての物性向上を目指したKeap1-リン酸化p62結合阻害剤の創製. 日本薬学会年会要旨集. 2018. 138年会. 2. 114-114
Matsumaru T, Yasuda D. Young innovators driving the next generation of academic drug discovery. Yakugaku Zasshi. 2018. 138. 8. 1025-1026

Patents (1)：

パーキンソン病治療薬

Lectures and oral presentations (20)：

新規Nrf2活性化剤KMN003が示す抗炎症作用の解析
(第97回日本生化学会大会 2024)
ビススルホンアミド型 Keap1-Nrf2 PPI 阻害剤の創製研究
(第50回反応と合成の進歩シンポジウム 2024)
特定のpH領域で機能する光機能分子の開発研究
(第50回反応と合成の進歩シンポジウム 2024)
<I>N</i><sup>1</sup>-メチルアデノシンを検出する蛍光センサーの開発研究
(第74回日本薬学会関西支部総会・大会 2024)
過酸化水素存在下で機能するケージド化合物の開発
(第74回日本薬学会関西支部総会・大会 2024)

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Education (2)：

2011 - 2014 Keio University Pharmaceutical Sciences Programs for Pharmaceutical Sciences
2009 - 2011 Keio University Pharmaceutical Sciences Programs for Pharmaceutical Sciences

Work history (3)：

2021/09 - 現在 Osaka Medical and Pharmaceutical University Faculty of Pharmacy Assistant Professor
2021/04 - 2021/08 Keio University Division of Molecular Design, Faculty of Pharmacy Project Lecturer
2014/04 - 2021/03 Keio University Faculty of Pharmacy Department of Pharmaceutical Sciences Project Assistant Professor

Committee career (2)：

2024/08 - 現在日本酸化ストレス学会若手の会役員
2022/09 - 現在薬学共用試験センター CBT実施委員

Awards (1)：

2021/06 - Society for Free Radical Research Japan Young Researcher's Award

Association Membership(s) (4)：

Society for Free Radical Research JAPAN , The Pharmaceutical Society of Japan , Division of Medicinal Chemistry, The Pharmaceutical Society of Japan , Japanese Society for Chemical Biology

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