Art

J-GLOBAL ID：202002247708979576   Reference number：20A0846542

Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine

ネビラピンの代謝活性化を研究するためのネビラピン類似体の合成と評価

Author (8)： Tateishi Yasuhiro (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Ohe Tomoyuki (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Yasuda Daisuke (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Takahashi Kyoko (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Nakamura Shigeo (Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino, Tokyo, Japan) ,  Kazuki Yasuhiro (Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori, Japan) ,  Kazuki Yasuhiro (Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, Japan) ,  Mashino Tadahiko (Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 35  Issue： 2  Page： 238-243  Publication year： 2020 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *anti-AIDS agent ,...
Semi thesaurus term： CYP3A4

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Author keywords (5)： Nevirapine ,  Metabolic activation ,  Cytochrome P450 ,  Hepatotoxicity ,  HepG2

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Nevirapine

Terms in the title (5)： ネビラピン ,  代謝活性化 ,  研究 ,  類似体 ,  評価