Rchr
J-GLOBAL ID:201601019112309930   Update date: Nov. 19, 2024

Wei Fanyan

ウエイ フアンイエン | Wei Fanyan
Affiliation and department:
Job title: Lecturer
Homepage URL  (1): https://www.modomics-medicine.com
Research field  (6): Metabolism and endocrinology ,  Ophthalmology ,  Molecular biology ,  Medical biochemistry ,  Clinical pharmacy ,  Physiology
Research keywords  (6): Mitochondria ,  Metabolism ,  RNA Modification ,  RNA ,  生理学 ,  physiology
Research theme for competitive and other funds  (22):
  • 2024 - 2029 A Study on Elucidating Obesity and Lifestyle Diseases through the Epigenome-RNA Modification Axis
  • 2023 - 2026 Molecular basis of RNA modification in immune response after transplantation and cell therapy and novel biomarkers
  • 2022 - 2026 A synthetic metabolic network based on RNA modification for biological homeostasis
  • 2021 - 2026 ミトコンドリアにおける超硫黄分子リレーの分子基盤と生理的意義の解明
  • 2021 - 2026 Management of international relation and facility for promotion of research on sulfur biology
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Papers (104):
  • Hidetaka S Oshima, Akiko Ogawa, Fumiya K Sano, Hiroaki Akasaka, Tomoyoshi Kawakami, Aika Iwama, Hiroyuki H Okamoto, Chisae Nagiri, Fan-Yan Wei, Wataru Shihoya, et al. Structural insights into the agonist selectivity of the adenosine A3 receptor. Nature communications. 2024. 15. 1. 9294-9294
  • Jin Matsuura, Shinichiro Akichika, Fan-Yan Wei, Tsutomu Suzuki, Takahiro Yamamoto, Yuka Watanabe, Leoš Shivaya Valášek, Akitake Mukasa, Kazuhito Tomizawa, Takeshi Chujo. Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation. Communications biology. 2024. 7. 1. 1238-1238
  • Kaori Ishikawa, Daiki Miyata, Satoko Hattori, Haruna Tani, Takayoshi Kuriyama, Fan-Yan Wei, Tsuyoshi Miyakawa, Kazuto Nakada. Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene induces brain dysfunction in mice. Pharmacological research. 2024. 208. 107374-107374
  • Roland Tresky, Yuta Miyamoto, Yu Nagayoshi, Yasushi Yabuki, Kimi Araki, Yukie Takahashi, Yoshihiro Komohara, Huicong Ge, Kayo Nishiguchi, Takaichi Fukuda, et al. TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic Acids Research. 2024
  • Raja Norazireen Raja Ahmad, Long-Teng Zhang, Rikuri Morita, Haruna Tani, Yong Wu, Takeshi Chujo, Akiko Ogawa, Ryuhei Harada, Yasuteru Shigeta, Kazuhito Tomizawa, et al. Pathological mutations promote proteolysis of mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic peptidase (CLPP). Nucleic acids research. 2023
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MISC (73):
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Patents (8):
Books (1):
  • Cyclin-Dependent Kinase 5 (Cdk5) (50)
    Springer 2008 ISBN:9780387788869
Lectures and oral presentations  (23):
  • tRNA修飾異常によるX染色体連鎖性精神遅滞の発症分子メカニズムの解析
    (第95回日本生理学会大会 2018)
  • ミトコンドリアtRNAタウリン修飾によるタンパク質恒常性ネットワークの制御
    (日本RNA学会年会 2017)
  • マウス個体発生におけるミトコンドリアtRNA修飾の役割
    (第30回モロシヌス研究会 2017)
  • tRNA 修飾異常によるX染色体連鎖性精神遅滞の発症分子メカニズムの解析
    (第93回日本生理学会大会 2016)
  • tRNA 修飾異常によるX染色体連鎖性精神遅滞の発症分子メカニズムの解析
    (第17回日本RNA学会年会 2015)
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Works (8):
  • RNAモドミクスの確立及び神経・精神疾患への応用
    2015 - 2019
  • ミトコンドリアtRNA修飾の分子基盤及び生理機能解析
    2015 - 2018
  • Cdkal1リスクアレル保有2型糖尿病患者に対する治療薬ならびにコンパニオン診断技術の開発
    2014 - 2017
  • Cdkal1リスクアレル保有者およびアジア型2型糖尿病を標的とした経口糖尿病薬の研 究開発
    2014 - 2015
  • ゲノムワイド関連研究成果に基づく新規2型糖尿病治療薬の開発
    2012 - 2013
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Professional career (1):
  • 博士(医学) (岡山大学)
Work history (7):
  • 2019/10 - 現在 Tohoku University Department of Modomics Biology and Medicine, IDAC Professor
  • 2017/03 - 2019/09 Kumamoto University
  • 2015/10 - 2019/03 Japan Science and Technology Agency
  • 2015/05 - 2017/02 Kumamoto University
  • 2009/04 - 2015/04 Kumamoto University
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Awards (8):
  • 2022/02 - JSPS Prize
  • 2017/03 - 熊本医学会賞
  • 2016/09 - EMBO Reports Prize
  • 2016 - 日本生理学会奨励賞
  • 2011 - 第23回分子糖尿病シンポジウム若手研究奨励賞
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Association Membership(s) (2):
THE RNA SOCIETY OF JAPAN ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN
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