Kanai Ryuta

Affiliation and department：

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (8)：

2021 - 2024 Na+,K+-ATPaseによるK+選択的結合機構の構造生物学的研究
2019 - 2022 Structural biology of active transport and its regulation by P-type ATPases
2018 - 2022 Structural basis for Na+-selectivity of the sodium pump
2016 - 2019 Structural elucidation of active transport by P-type ATPases
2016 - 2019 structural basis of channelization of Na+-pump by palytoxin

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Papers (28)：

Takaharu Sakuragi, Ryuta Kanai, Mayumi Otani, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata. The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase. The Journal of biological chemistry. 2024. 300. 3. 105755-105755
Ryuta Kanai, Bente Vilsen, Flemming Cornelius, Chikashi Toyoshima. Crystal structures of Na+ ,K+ -ATPase reveal the mechanism that converts the K+ -bound form to Na+ -bound form and opens and closes the cytoplasmic gate. FEBS letters. 2023
Xingya Xu, Ryuta Kanai, Li Wang, Mitsuhiro Yanagida. Cohesin ATPase activities regulate DNA binding and coiled-coil configuration. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 33. e2208004119
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima. Cryo-electron microscopy of Na+ ,K+ -ATPase reveals how the extracellular gate locks in the E2·2K+ state. FEBS letters. 2022
Ryuta Kanai, Flemming Cornelius, Bente Vilsen, Chikashi Toyoshima. Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 15. e2123226119

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Education (2)：

Professional career (1)：

Work history (8)：

2023/05 - 現在 The University of Tokyo
2020/04 - 2023/04 The University of Tokyo
2018/04 - 2020/03 The University of Tokyo
2010/07 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences
2009/04 - 2010/06 Yale University (USA) Dept. of Molecular Biophysics and Biochemistry

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