Research theme for competitive and other funds (1):
2015 - 2019 The establishment of new therapy targeting metabolic characteristics and cancer-stroma interaction for pancreatic cancer
Papers (8):
Misa Yokoyama, Nobuhiro Tanuma, Rie Shibuya, Takeharu Shiroki, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Kazunori Yamaguchi, Ikuro Sato, Keiichi Tamai, et al. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species. International Journal of Oncology. 2018. 52. 3. 881-891
Takeharu Shiroki, Misa Yokoyama, Nobuhiro Tanuma, Ryuhei Maejima, Keiichi Tamai, Kazunori Yamaguchi, Tomoyuki Oikawa, Tetsuya Noguchi, Koh Miura, Tsuneaki Fujiya, et al. Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism. CANCER SCIENCE. 2017. 108. 5. 931-940
Takeharu Shiroki, Misa Yokoyama, Ryuhei Maejima, Keiichi Tamai, Kazunori Yamaguchi, Tomoyuki Oikawa, Tetsuya Noguchi, Koh Miura, Tsuneaki Fujiya, Ikuro Sato, et al. PKM2 Is Dominantly Expressed in Normal Gastric Mucosa and Its Overexpression Is Involved in Gastric Cancer Development. GASTROENTEROLOGY. 2015. 148. 4. S563-S563
M. Abue, M. Yokoyama, R. Shibuya, K. Tamai, I. Sato, N. Tanaka, K. Yamaguch, S. Hamada, T. Shimosegawa, K. Sugamura, et al. The Evaluation of Circulating miR-483-3p and miR-21 in Plasma of Pancreatic Ductal Adenocarcinoma Patients. PANCREAS. 2014. 43. 8. 1340-1340
M. Yokoyama, R. Shibuya, T. Shiroki, N. Tanuma, K. Tamai, K. Yamaguchi, N. Tanaka, K. Sugamura, K. Satoh. Pyruvate Kinase Type M2 (PKM2) Is Selectively Expressed and Involved in Survival and Development in Pancreatic Ductal Adenocarcinoma Cells. PANCREAS. 2014. 43. 8. 1427-1428
2014/11 - Young Investigator Award ”Pyruvate kinase type M2 (PKM2) is selectively expressed and involved in survival and development in pancreatic ductal adenocarcinomacells”