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J-GLOBAL ID：201702253074291428   Reference number：17A0655917

Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism

ピルビン酸キナーゼのM2アイソフォームの高発現は癌特異的代謝を制御することによって胃癌発症に関わる

Author (19)： Shiroki Takeharu (Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Shiroki Takeharu (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Yokoyama Misa (Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Tanuma Nobuhiro (Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Maejima Ryuhei (Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Maejima Ryuhei (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Tamai Keiichi (Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Yamaguchi Kazunori (Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Oikawa Tomoyuki (Department of Gastroenterology, Miyagi Cancer Center, Natori, Japan) ,  Noguchi Tetsuya (Department of Gastroenterology, Miyagi Cancer Center, Natori, Japan) ,  Miura Koh (Department of Gastroenterological Surgery, Miyagi Cancer Center, Natori, Japan) ,  Fujiya Tsuneaki (Department of Gastroenterological Surgery, Miyagi Cancer Center, Natori, Japan) ,  Shima Hiroshi (Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan) ,  Sato Ikuro (Department of Pathology, Miyagi Cancer Center, Natori, Japan) ,  Murata-Kamiya Naoko (Department of Microbiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan) ,  Hatakeyama Masanori (Department of Microbiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan) ,  Iijima Katsunori (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Shimosegawa Tooru (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Satoh Kennichi (Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 5  Page： 931-940  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： knockdown cell ,...

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Author keywords (5)： Aerobic glycolysis ,  CagA ,  cancer development ,  gastric cancer ,  pyruvate kinase

JST classification (3)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Enzyme in general  (EB09010D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (35)：

• Warburg O. On the origin of cancer cells. Science 1956; 123: 309-14.
• Anastasiou D, Poulogiannis G, Asara JM et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011; 334: 1278-83.
• Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins 2001; 43: 175-85.
• Christofk HR, Vander Heiden MG, Harris MH et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452: 230-3.
• Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008; 452: 181-6.

Terms in the title (7)： ピルビン酸キナーゼ ,  アイソフォーム ,  発現 ,  癌 ,  代謝 ,  胃癌 ,  発症