Rchr
J-GLOBAL ID：201801000077755894
Update date: Dec. 05, 2024
Tokuda Eiichi
トクダ エイイチ | Tokuda Eiichi
Affiliation and department：
Job title：
Lecturer (Group Leader)
Homepage URL (1)：
https://www.pha.nihon-u.ac.jp/
Research field (4)：
Neuropathology
, Pathobiochemistry
, Functional biochemistry
, Molecular biology
Research keywords (14)：
amyotrophic lateral sclerosis
, dementia
, neurodegenerative diseases
, protein aggregates
, SOD1
, TDP-43
, cell-to-cell transmission
, endocytosis
, endosome
, autophagy
, recombinant proteins
, cellular models
, animal models
, metallothionein
Research theme for competitive and other funds (25)：
- 2024 - 2026 Research on the pathogenesis of Alzhiemer's disease based on the novel stoichometrical molecular analyses in intracellular micro-regions.
- 2022 - 2025 Understating of disease process for ALS from the viewpoint of endosomal pH regulation.
- 2023 - 2024 Establishment of a principle that can entrap protein aggregates with cell-to-cell transmission inside the cells
- 2023 - 2024 How does endosome contributes to the pathogenesis of protein conformational diseases?
- 2022 - 2023 Search for the Hofmeister series ions that facilitate the aggregation of ALS related proteins and their application for ALS diagnosis
- 2021 - 2023 Development of hemodiagnosis for amyotrophic lateral sclerosis based on seeding reaction of misfolded protein
- 2022 - 2023 Are protein aggregate strains associated with phenotypic diversity of ALS?
- 2021 - 2022 Cell-to-cell transmission of ALS-related protein aggregates that initially spread from endosomes
- 2021 - 2022 Understanding of cell-to-cell spread of ALS linked-protein aggregates, learning from a theory of proton sponge effect in Drug Delivery Science
- 2021 - 2022 Development of hemodiagnosis for amyotrophic lateral sclerosis based on seeding reaction of misfolded protein
- 2021 - 2022 Does an endocytic receptor LRP2 regulate cell-to-cell transmission of SOD1 aggregates?
- 2020 - 2021 Therapeutic strategy for ALS targeting interaction between an endocytic receptor LRP2 and SOD1 aggregates
- 2020 - 2021 Development of blood diagnosis for ALS based on seeding reaction of misfolded proteins
- 2020 - 2021 Development of a proteome approach that comprehensively detects factors interacting with prion-like protein aggregates
- 2019 - 2020 Search for endocytosis inducers that are capable of efficiently removing extracellular misfoldded proteins
- 2017 - 2019 The role of cross-seeding in the pathogenesis of neurodegenerative diseases
- 2016 - 2018 Amylodosis potentially elicited by medicines: risk factor of development of neurodegenerative diseases?
- 2015 - 2017 Study on molecular mechanisms that accelerates the disease process of neurodegenerative diseases
- 2015 - 2016 Development of C. elegans models for study on disease progression of Parkinson's disease
- 2015 - 2016 神経変性疾患の病態拡大を評価できる新しいモデル動物の構築
- 2015 - 2016 神経変性疾患の病態が拡大・伝播する分子メカニズムの解明
- 2015 - 2016 筋萎縮性側索硬化症の病態伝播メカニズムを解明するための新たな線虫モデルの確立
- 2015 - 2016 新規の線虫モデルを利用したALS病態伝播メカニズムの検証
- 2010 - 2011 Dose extracellular SOD3 have a protective effect against vascular damage seen in ALS?
- 2008 - 2010 Development of novel therapies for amyotrophic lateral sclerosis
Show all
Papers (31)：
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Eiichi Tokuda, Yume Sakashita, Naoya Tokoro, Ayano Date, Yasuhiro Kosuge, Tomohiro Miyasaka. MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons. International Journal of Molecular Sciences. 2024. 25. 11. 5603-5603
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Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Toshihiko Sugiki, Hayato Ito, Asako Murata, Akira Ishiguro, Tania F. Gendron, Kohji Mori, et al. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD. eLife. 2023. 12. RP84338
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Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-Ichi Ono, Eiichi Tokuda. A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells. International Journal of Molecular Sciences. 2021. 22. 8
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Mikako Hirose, Mito Asano, Saori Watanabe-Matsumoto, Koji Yamanaka, Yoichiro Abe, Masato Yasui, Eiichi Tokuda, Yoshiaki Furukawa, Hidemi Misawa. Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS. Neuroscience Research. 2020. 171. 74-82
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Yoshiaki Furukawa, Eiichi Tokuda. Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?. Translational Neurodegeneration. 2020. 9. 1
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MISC (65)：
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徳田栄一. SOD1タンパク質が毒性の高い異常な構造を形成する新たなメカニズム. ファルマシア(Web). 2024. 60. 5
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徳田栄一, 川名麻衣. Development of hemodiagnosis for sporadic ALS based on the seeding reaction by misfolded SOD1. 日本薬学会年会要旨集(Web). 2024. 144th
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徳田栄一, 阪下優芽, 山老直哉. Characterization of misfolded SOD1 species that are recognized by a commercially available antibody MS785. 日本薬学会年会要旨集(Web). 2023. 143rd
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徳田 栄一, 桂馬 茉衣子, 池田 知亜子, 小菅 康弘, 小野 真一. ALS病因タンパク質の凝集を抑制するZn結合型メタロチオネイン. 日本薬学会年会要旨集. 2022. 142年会. 26F-pm13
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徳田栄一, 桂馬茉衣子, 池田知亜子, 小菅康弘, 小野真一. Zn結合型メタロチオネインによるALS関連タンパク質の凝集抑制. 日本神経化学会大会抄録集(Web). 2022. 65th
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Patents (1)：
Books (1)：
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Brain Diseases and Metalloproteins
Pan Stanford Publishing 2012 ISBN:9789814316019
Lectures and oral presentations (16)：
-
Neuroprotection of metallothionein in ALS-SOD1 is mediated by an endocytic receptor LRP2/Megalin
(1st International Symposium on Metal in ALS 2019)
-
Wild-type SOD1 is misfolded in cerebrospinal fluid of sporadic ALS
(2018)
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Development of peptides that specifically recognize misfolded SOD1 proteins in amyotrophic lateral sclerosis
(28th International Symposium on ALS/MND 2017)
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In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates
(27th International Symposium on ALS/MND. 2016)
-
Human spinal ventral horn contains a lower autophagic capacity than other CNS areas: Implication for selective vulnerability of motor system in ALS
(26th International Symposium on ALS/MND 2015)
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Education (3)：
- 2007 - 2010 Graduate School of Nihon University Pharmaceutical Sciences Ph.D. Course
- 2005 - 2007 Graduate School of Nihon University Pharmaceutical Sciences Master's Course
- 2001 - 2005 Nihon University School of Pharmacy
Professional career (1)：
- Ph.D (Pharmaceutical Sciences) (Nihon University)
Work history (5)：
- 2019/04 - 現在 Nihon University School of Pharmacy Senior Research Associate
- 2018/04 - 2019/03 Tokushima Bunri University Faculty of Pharmaceutical Sciences Senior Research Associate
- 2015/04 - 2018/03 Keio University Department of Chemistry Assistant Professor
- 2010/04 - 2015/03 Umea University, Sweden Department of Medical Biosciences Post-doc
- 2008/04 - 2010/03 Japan Society of the Promotion of Sciences Research Fellow
Committee career (3)：
- 2022/06 - 現在 International Journal of Molecular Sciences (MDPI, Switzerland) Topic Advisory Panel
- 2021/09 - 現在 National Institute of Science and Technology Policy NISTEP investigator
- 2020/01 - 現在 Life (MDPI, Switzerland) Advisory Board
Awards (3)：
- 2021/12 - The Serika Fund Research Encouragement Award
- 2010/02 - The Naito Foundation Fellowship for research overseas
- 2009/10 - Japanese Society of Metal Biosciences Research Encouragement Award
Association Membership(s) (5)：
Japan Society for Dementia Research
, ENCALS
, THE JAPANESE SOCIETY OF TOXICOLOGY
, THE JAPAN NEUROSCIENCE SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
