Art

J-GLOBAL ID：202002288956932808   Reference number：20A0028181

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

野生型Cu/Znスーパーオキシドジスムターゼは散発性筋萎縮性側索硬化症の脳脊髄液において誤って折畳まれる【JST・京大機械翻訳】

Author (8)： Tokuda Eiichi (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan) ,  Takei Yo-ichi (Department of Neurology, Matsumoto Medical Center, Matsumoto, Japan) ,  Ohara Shinji (Department of Neurology, Matsumoto Medical Center, Matsumoto, Japan) ,  Ohara Shinji (Department of Neurology, Iida Hospital, Iida, Japan) ,  Fujiwara Noriko (Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan) ,  Hozumi Isao (Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University, Gifu, Japan) ,  Hozumi Isao (Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan) ,  Furukawa Yoshiaki (Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Japan)
Material： Molecular Neurodegeneration (Web)
Volume： 14  Issue： 1  Page： 1-21  Publication year： 2019 
JST Material Number： U7339A  ISSN： 1750-1326  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： A subset of familial forms of ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0028181&from=J-GLOBAL&jstjournalNo=U7339A") }}

Thesaurus term： motor nerve ,  *cerebrospinal fluid ,  antibody ,  immunoprecipitation ,  folding (morphology) ,  Parkinson's disease ,  sensitivity ,  Proteins ,  *Superoxide Dismutase ,  subset ,  Mutation ,  *wild type ,  *Spinal Cord ,  gene ,  *Amyotrophic Lateral Sclerosis ,  *body fluid ,  bioassay ,  immunoassay

Author keywords (4)： Amyotrophic lateral sclerosis (ALS) ,  Cerebrospinal fluid (CSF) ,  Cu/Zn-superoxide dismutase (SOD1) ,  Protein misfolding

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U)

Reference (79)：

• Nat Rev Neurol; Clinical genetics of amyotrophic lateral sclerosis: what do we really know?; PM Andersen, A Al-Chalabi; 7; 2011; 603-615; 10.1038/nrneurol.2011.150; citation_id=CR1
• Nat Rev Neurosci; The changing scene of amyotrophic lateral sclerosis; W Robberecht, T Philips; 14; 2013; 248-264; 10.1038/nrn3430; citation_id=CR2
• Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59-62.
• Neurology.; Prevalence of SOD1 mutations in the Italian ALS population; A Chio, BJ Traynor, F Lombardo, M Fimognari, A Calvo, P Ghiglione; 70; 2008; 533-537; 10.1212/01.wnl.0000299187.90432.3f; citation_id=CR4
• Neurobiol Aging; Screening of the SOD1, FUS, TARDBP, ANG, and OPTN mutations in Korean patients with familial and sporadic ALS; MJ Kwon, W Baek, CS Ki, HY Kim, SH Koh, JW Kim; 33; 2012; 1017 e1017-1017 e1023; 10.1016/j.neurobiolaging.2011.12.003; citation_id=CR5

Terms in the title (6)： 野生型 ,  Cu ,  Zn ,  スーパーオキシドジスムターゼ ,  散発性筋萎縮性側索硬化症 ,  脳脊髄液