odaka haruki

オダカハルキ | odaka haruki

Affiliation and department：

Research field (2)： Cell biology , Neuroanatomy and physiology

Research keywords (2)： iPS細胞 , 神経科学

Research theme for competitive and other funds (6)：

2022 - 2026 脳内老化細胞の1細胞糖鎖解析による新規細胞表面マーカーの探索と糖鎖機能の解明
2020 - 2023 Role of the interaction between microglia and neuron in the defected neuronal function in the lysosomal storage disease
2020 - 2023 Development of novel pathological analysis and medicine in neuropathic Gaucher disease.
2019 - 2021 ヒト脳スフェロイド内のグリア挙動に着目したストレスに起因する発達障害病態の解明
2016 - 2019 Investigation of cellular/molecular pathophysiology of brain disorders using human brain organoids established from iPS cells

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Papers (26)：

Tadahiro Numakawa, Haruki Odaka. The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases. International Journal of Molecular Sciences. 2022. 23. 14. 7726-7726
Haruki Odaka, Tadahiro Numakawa, Minami Soga, Jun Kido, Shiro Matsumoto, Ryutaro Kajihara, Toshika Okumiya, Naoki Tani, Yuki Tanoue, Takaichi Fukuda, et al. An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca2+ dynamics. Neurobiology of disease. 2021. 152. 105279-105279
Haruki Odaka, Keiko Hiemori, Asako Shimoda, Kazunari Akiyoshi, Hiroaki Tateno. Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. FEBS open bio. 2021. 11. 3. 741-752
Ryutaro Kajihara, Tadahiro Numakawa, Haruki Odaka, Yuji Yaginuma, Noemi Fusaki, Toshika Okumiya, Hirokazu Furuya, Seiji Inui, Takumi Era. Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation. Stem cell reports. 2020. 14. 5. 909-923
Takumi Era, Kozo Matsushita, Ryutaro Kajihara, Haruki Odaka, Minami Soga, Kimitoshi Nakamura, Tadahiro Numakawa. Abnormalities of neural function in neurons derived from induced pluripotent stem cells from Tay-Sachs disease patients. Molecular Genetics and Metabolism. 2020. 129. 2. S54-S54

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MISC (2)：

曽我美南, 梶原隆太郎, 沼川忠広, 小高陽樹, 柳沼裕二, 房木ノエミ, 奥宮敏可, 古谷博和, 乾誠治, 江良択実. ガングリオシドーシス由来神経細胞の新しい異常表現型とそれを使った薬剤開発. 日本先天代謝異常学会雑誌. 2021. 37. 140-140
Tadahiro Numakawa, Haruki Odaka. Brain-derived neurotrophic factor signaling in the pathophysiology of alzheimer’s disease: Beneficial effects of flavonoids for neuroprotection. International Journal of Molecular Sciences. 2021. 22. 11

Books (1)：

Factors Affecting Neurodevelopment 1st Edition Genetics, Neurology, Behavior, and Diet
Elsevier 2021

Lectures and oral presentations (8)：

SIALIDOSIS NEURONS FROM PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELL EXHIBIT SYNAPTIC DYSFUNCTION
(International Society for Stem Cell Research Annual Meeting 2018 2018)
シアリドーシス患者由来iPS細胞を用いた神経系細胞の病態解析
(幹細胞シンポジウム第7回幹細胞若手の会 2018)
シアリドーシス患者iPS 細胞を用いた神経障害の病理学的解析
(第59回日本先天性代謝異常学会総会 2017)
Improvement of genetically-encoded yellow fluorescent cAMP indicator for dual-color imaging
(第37回日本分子生物学会年会 2014)
培養大脳皮質ニューロンに対するカベルゴリン(ドーパミンD2受容体アゴニスト)の神経保護効果の解析
(第57回日本神経化学会大会 2014)

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Education (3)：

Professional career (1)：

Work history (4)：

2020/04 - 現在産業技術総合研究所細胞分子工学研究部門多細胞システム制御研究グループ研究員
2019/04 - 2020/03 熊本大学発生医学研究所幹細胞誘導分野特定事業研究員
2018/04 - 2019/03 Kumamoto University Institute of Molecular Embryology and Genetics
Waseda University Faculty of Science and Engineering

Association Membership(s) (3)：

日本先天性代謝異常学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY

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