Art

J-GLOBAL ID：202002269818783822   Reference number：20A1084323

Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation

新規薬物候補はオートファジー活性化を伴うGM1神経節症モデルにおけるガングリオシド蓄積と神経機能障害を改善する【JST・京大機械翻訳】

Author (10)： Kajihara Ryutaro (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Kajihara Ryutaro (Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0976, Japan) ,  Numakawa Tadahiro (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Odaka Haruki (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan) ,  Yaginuma Yuji (Department of Morphological and Physiological Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0976, Japan) ,  Fusaki Noemi (University Research Administration Center, Office of Research Promotion, Tohoku University, Tohoku 980-8577, Japan) ,  Okumiya Toshika (Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0976, Japan) ,  Furuya Hirokazu (Department of Neurology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan) ,  Inui Seiji (Department of Biomedical Laboratory Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0976, Japan) ,  Era Takumi (Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan)
Material： Stem Cell Reports
Volume： 14  Issue： 5  Page： 909-923  Publication year： 2020 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： GM1 gangliosidosis is a lysoso...

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Thesaurus term： neuron ,  *ganglioside ,  synapse ,  *ganglia ,  lysosome ,  in vitro experiment ,  beta-galactosidase ,  induced pluripotent stem cell ,  *autophagy
Semi thesaurus term： 神経変性 ,  *ガングリオシドGM1 ,  細胞モデル ,  神経機能 ,  薬物スクリーニング ,  臨床応用 , 【Automatic Indexing@JST】

Author keywords (4)： induced pluripotent stem cells ,  lysosomal storage disease ,  GM1 gangliosidosis ,  drug development

JST classification (2)： Basic neurology  (GN01020W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Terms in the title (9)： 薬物 ,  オートファジー ,  活性化 ,  神経節 ,  モデル ,  ガングリオシド ,  蓄積 ,  神経 ,  機能障害