Rchr
J-GLOBAL ID：201801000271422685   Update date: Sep. 11, 2024

Mukae Kyosuke

ムカエ キョウスケ | Mukae Kyosuke
Affiliation and department：
Saitama Cancer Center Research Institute for Clinical Oncology

About Saitama Cancer Center Research Institute for Clinical Oncology


Research field  (2)： Plants: molecular biology and physiology ,  Tumor biology
Research keywords  (3)： iPS細胞 ,  神経芽腫 ,  腫瘍生物学
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 Research on highly efficient RNA and DNA extraction of trace specimens and systemization of pre-processing for analysis
  • 2022 - 2025 Development of treatment for malignant tumors using a neuroblastoma model derived from iPS cells
  • 2022 - 2023 MYCN増幅/ALK変異神経芽腫における発がん機構の解明(代表)
  • 2020 - 2023 神経芽腫発がんにおける網羅的遺伝子破壊を用いたセカンドヒット遺伝子領域の探索(分担)
  • 2019 - 2022 iPS細胞による神経芽腫発がんモデルを用いたALT陽性難治腫瘍の治療開発
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Papers (24)：
  • Ryu Okada, Hisanori Takenobu, Shunpei Satoh, Ryuichi P. Sugino, Ritsuko Onuki, Masayuki Haruta, Kyosuke Mukae, Atsuko Nakazawa, Jesmin Akter, Miki Ohira, et al. L3MBTL2 maintains MYCN-amplified neuroblastoma cell proliferation through silencing NRIP3 and BRME1 genes. Genes to Cells. 2024
  • Md Arif Sakil, Kyosuke Mukae, Junyu Bao, Abhishek Sadhu, Md. Shyduzzaman Roni, Yuko Inoue-Aono, Yuji Moriyasu. Autophagy promotes cell death induced by hydrogen peroxide in Physcomitrium patens. Plant And Cell Physiology. 2023
  • Kyosuke Mukae, Osamu Takei, Fumi Imai, Takehiko Kamijo. Development of RNA/DNA automated extraction and purification device for infectious disease diagnosis. Practical Laboratory Medicine. 2023. 37. e00335-e00335
  • Kyosuke Mukae, Md. Arif Sakil, Toshihisa Kotake, Yuko Inoue-Aono, Yuji Moriyasu. Autophagy accelerates cell death after desiccation and hydration stress in Physcomitrium. Environmental and Experimental Botany. 2023. 213. 105412-105412
  • Sultana Parvin, Jesmin Akter, Hisanori Takenobu, Yutaka Katai, Shunpei Satoh, Ryu Okada, Masayuki Haruta, Kyosuke Mukae, Tomoko Wada, Miki Ohira, et al. ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors. BMC Cancer. 2023. 23. 1
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MISC (6)：
  • 迎 恭輔, 竹信 尚典, 杉野 隆一, 大平 美紀, 佐藤 俊平, 遠藤 悠紀, 岡田 龍, 春田 雅之, 戸口田 淳也, 長船 健二, et al. iPS細胞由来神経堤細胞の神経芽腫発生メカニズム解析のための細胞モデル開発(Development of neuroblastoma model from iPS-based neural crest cells for analysis of neuroblastoma tumorigenesis). 日本癌学会総会記事. 2018. 77回. 1278-1278
  • 遠藤 悠紀, 竹信 尚典, 杉野 隆一, 春田 雅之, 迎 恭輔, 佐藤 俊平, 秦 佳孝, 長谷川 真理子, 岡田 龍, 片井 友貴, et al. 神経芽腫におけるEZH2阻害剤の感受性を制御する分子の探索(Identification of molecules that regulate the sensitivity of EZH2 inhibitor in neuroblastoma). 日本癌学会総会記事. 2018. 77回. 1965-1965
  • Hisanori Takenobu, Ryuichi Sugino, Miki Ohira, Koji Chikaraishi, Kyosuke Mukae, Yuki Endo, Sultana Parvin, Ryu Okada, Yutaka Katai, Masayuki Haruta, et al. Sphere Specific Transcription Factor CDX1 Regulates Stemness of Neuroblastoma. PEDIATRIC BLOOD & CANCER. 2017. 64. S46-S46
  • Hisanori Takenobu, Zhenghao Li, Amallia Setyawati, Nobuhiro Akita, Masayuki Haruta, Shunpei Satoh, Yoshitaka Shinno, Koji Chikaraishi, Kyosuke Mukae, Jesmin Akter, et al. EZH2 Regulates Neuroblastoma Cell Differentiation via NTRK1 Promoter Epigenetic Modifications. PEDIATRIC BLOOD & CANCER. 2017. 64. S22-S23
  • Koji Chikaraishi, Hisanori Takenobu, Ryuichi Sugino, Kyosuke Mukae, Akter Jesmin, Masayuki Haruta, Masafumi Kurosumi, Takaho Endo, Haruhiko Koseki, Naoki Shimojo, et al. Effect of CFC1 on Cancer Cell Stemness in Neuroblastoma. PEDIATRIC BLOOD & CANCER. 2017. 64. S49-S49
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Patents (2)：
  • 核酸抽出方法、及び核酸抽出装置
  • 環境ストレスに対する植物の耐性を強化させる方法
Lectures and oral presentations  (4)：
  • ヒトiPS細胞由来頭部神経堤細胞 からのTP53変異/MYCN高発現を伴う 軟骨芽細胞型骨肉腫モデルの開発
    (【先端モデル動物支援プラットフォーム】成果発表会 2024)
  • Development of a chondroblastic osteosarcoma model from iPSC-based neural crest cells
    (2021)
  • Development of artificial tumorigenesis model from iPSC-based neural crest cells
    (第62回日本小児血液・がん学会学術集会 2020)
  • iPS細胞由来神経堤細胞の神経芽腫発生メカニズム解析のための細胞モデル開発
    (第77回日本癌学会学術総会 2018)
Work history (1)：
  • 2015/10 - 現在 埼玉県立がんセンター
Awards (1)：
  • 2021/10 - JCA Young Researcher Poster Award Development of a chondroblastic osteosarcoma model from iPSC-based neural crest cells
Association Membership(s) (4)：
THE BOTANICAL SOCIETY OF JAPAN ,  JAPANESE SOCIETY FOR CRYOBIOLOGY AND CRYOTECHNOLOGY ,  THE JAPANESE CANCER ASSOCIATION ,  The Japanese Society of Pediatric Hematology/Oncology
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