Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (3)：
核酸化学
, 低分子
, 有機合成化学
Research theme for competitive and other funds (3)：
2020 - 2021 アミン骨格を有するCDN誘導体を利用した新規バイオフィルム形成阻害剤の開発
2019 - ペプチド構造を有する環状ジヌクレオチド等価体を利用した創薬研究
2018 - 2019 環状ジヌクレオチド等価体の効率的合成とその機能評価
Papers (72)：
Hanqiao Xu, Nobumichi Ohoka, Takao Inoue, Hidetomo Yokoo, Yosuke Demizu. Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation. Bioorganic & medicinal chemistry letters. 2024. 107. 129778-129778
Miki Nakamura, Nobumichi Ohoka, Norihito Shibata, Takao Inoue, Genichiro Tsuji, Yosuke Demizu. Development of STING degrader with double covalent ligands. Bioorganic & Medicinal Chemistry Letters. 2024. 102. 129677-129677
Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka. Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins. Bioorganic Chemistry. 2024. 145. 107204-107204
Hidetomo Yokoo, Yoshitaka Aoyama, Takashi Matsumoto, Eiichi Yamamoto, Nahoko Uchiyama, Yosuke Demizu. Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction. Chemical & pharmaceutical bulletin. 2024. 72. 5. 471-474
Motoharu Hirano, Hidetomo Yokoo, Nobumichi Ohoka, Takahito Ito, Takashi Misawa, Makoto Oba, Takao Inoue, Yosuke Demizu. Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures. Chemical & pharmaceutical bulletin. 2024. 72. 2. 149-154
水谷佐久美, 河村麻衣子, 田中理恵, 三澤隆史, 辻厳一郎, 黒原崇, 伊藤美千穂, 出水庸介, 花尻(木倉)瑠理. Simultaneous analysis of 23 compounds derived from constituents of cannabis. 日本薬学会年会要旨集(Web). 2023. 143rd
永沼美弥子, 大岡伸通, 辻厳一郎, 内藤幹彦, 井上貴雄, 出水庸介, 出水庸介, 出水庸介. Development of chemically stabilized decoy-based PROTAC. 日本薬学会年会要旨集(Web). 2023. 143rd
河村麻衣子, 三澤隆史, 辻厳一郎, 黒原崇, 伊藤美千穂, 出水庸介, 花尻(木倉)瑠理. Study on analytical methods for derivatives of cannabis constituents. 日本薬学会年会要旨集(Web). 2023. 143rd
古内志拓, 人見悠毅, 佐々木智未, 岡本岳大, 辻厳一郎, 黒原崇, 出水庸介, 大野修, 松野研司. Structure determination and total synthetic study on KNP-1, a cyclic depsipeptide that inhibits kynurenine production. 日本薬学会年会要旨集(Web). 2023. 143rd
2018/10 - 現在 National Institute of Health Sciences Division of Organic Chemistry Researcher
2017/09 - 2018/09 National Institute of Health Science Division of Organic Chemistry Researcher
2015/04 - 2017/08 University of Nagoya Deparement of Science Pos-Doc Researcher
2015/12 - 2016/03 University of Purdue Department of Chemistry Pos-Doc Researcher
2014/04 - 2015/11 University of Maryland, College Park Department of Chemistry and Biochemistry Pos-Doc researcher
2013/04 - 2014/03 University of Tohoku, IMRAM
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Association Membership(s) (5)：
JAPANESE SOCIETY FOR FOOD HYGIENE AND SAFETY
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE CHEMICAL SOCIETY OF JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, JAPANESE ASSOCIATION OF FORENSIC TOXICOLOGY
