Ryoji Ito

イトウリョウジ | Ryoji Ito

Affiliation and department：
Job title： Lab head

Research field (2)： Immunology , Laboratory animal science

Research keywords (4)： Allergy , Hematopoietic stem cells , Immunology , humanized mice

Research theme for competitive and other funds (12)：

2023 - 2026 高生着性次世代NOGマウスの開発と汎用的ヒト化マウス作製の基盤技術構築
2021 - 2024 ヒトの腸内細菌叢と免疫系を再構築したデュアルヒト化マウスの開発
2021 - 2024 免疫ヒト化マウスを用いた心理社会的ストレス関連喘息の分子病態の解明
2020 - 2023 Development of atopic dermatitis models using humanized mice for eosinophil target therapy
2019 - 2022 Establishment and analysis of humanized murine model for refractory asthma

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Papers (66)：

Satoshi Nunomura, Ryoji Ito, Yasuhiro Nanri, Yusuke Ohno, Yuko Honda, Hironobu Takedomi, Kenji Izuhara. Novel mechanisms by which benralizumab suppresses IgE expression in human B cells in humanized mice. Allergy. 2023
Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Naoya Takayama, Naoki Itokawa, Shuhei Koide, Asuka Shibamiya, Yurie Miyamoto-Nagai, Mohamed Rizk, et al. UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. Leukemia. 2023. 37. 9. 1895-1907
Yuyo Ka, Ryoji Ito, Ryoko Nozu, Kayo Tomiyama, Masami Ueno, Tomoyuki Ogura, Riichi Takahashi. Establishment of a human microbiome- and immune system-reconstituted dual-humanized mouse model. Experimental animals. 2023. 72. 3. 402-412
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi, Norie Murayama, Hiroshi Yamazaki, Kazuhiro Murai, Hayato Hikita, Tetsuo Takehara, et al. HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. Biochemical and biophysical research communications. 2023. 663. 132-141
Masatoshi Sakurai, Kantaro Ishitsuka, Ryoji Ito, Adam C Wilkinson, Takaharu Kimura, Eiji Mizutani, Hidekazu Nishikii, Kazuhiro Sudo, Hans Jiro Becker, Hiroshi Takemoto, et al. Chemically defined cytokine-free expansion of human haematopoietic stem cells. Nature. 2023. 615. 7950. 127-133

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MISC (6)：

山田志保, 豊島翔太, 丸岡秀一郎, 伊藤亮治, 岡山吉道, 權寧博. ヒト化IgE依存性喘息モデルの作製. 日本呼吸器学会誌. 2022. 11. 増刊. 193-193
豊島翔太, 丸岡秀一郎, 曽田香織, 伊藤亮治, 山田志保, 岡山吉道, 権寧博. 喘息(自然免疫・性差) ヒト化自然免疫型喘息モデルを用いたベンラリズマブの治療効果検討. アレルギー. 2021. 70. 6-7. 793-793
丸岡秀一郎, 伊藤亮治, 布村聡, 権寧博, 曽田香織, 太田昭一郎, 出原賢治, 伊藤守, 橋本修. NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発. 日本呼吸器学会誌(Web). 2017. 6. 207
丸岡秀一郎, 伊藤亮治, 布村聡, 権寧博, 曽田香織, 太田昭一郎, 出原賢治, 伊藤守, 橋本修. NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発. 日本呼吸器学会誌. 2017. 6. 増刊. 207-207
Ken-ya Sato, Ryo Oiwa, Wakako Kumita, Akiko Shimada, Takashi Inoue, Takeshi Kuge, Norio Okahara, Junko Okahara, Ryoko Nozu, Ryoji Ito, et al. Production of an immunodeficient common marmoset by ZFN-based mutagenesis. TRANSGENIC RESEARCH. 2014. 23. 5. 873-874

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Patents (4)：

Education (1)：

Work history (4)：

2019/04 - 現在 Central Institute for Experimental Animals
2015/04 - 2019/03 Central Institute for Experimental Animals Immunology Laboratory
2014/04 - 2015/03 La Jolla Institute for Immunology Post doctoral fellow
2005/10 - 2014/03 Central Institute for Experimental Animals Immunology Laboratory

Awards (5)：

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