Osawa Tsuyoshi

Osawa Tsuyoshi | Osawa Tsuyoshi

Affiliation and department：
Homepage URL (1)： https://www.onc.rcast.u-tokyo.ac.jp/ja/

Research field (1)： Tumor biology

Research keywords (1)：分子腫瘍学

Research theme for competitive and other funds (16)：

2022 - 2025 横紋筋肉腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索
2022 - 2025 腎芽腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索
2021 - 2024 腎芽腫患児の代謝物網羅解析によるバイオマーカーの探索と創薬への挑戦
2021 - 2023 Elucidation of metabolointeractome in tumor microenvironments
2019 - 2023 Tolerance of cancer cells against amino acids deprivation in tumor microenvironments

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Papers (41)：

Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein expression and purification. 2023. 106375-106375
Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, et al. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO journal. 2023. e114032
Miki Kato, Keisuke Maeda, Ryuichi Nakahara, Haruka Hirose, Ayano Kondo, Sho Aki, Maki Sugaya, Sana Hibino, Miyuki Nishida, Manami Hasegawa, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS nexus. 2023. 2. 10. pgad306
Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi, Hideyuki Yanai. Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 24. e2305245120
Sho Aki, Ryuichi Nakahara, Keisuke Maeda, Tsuyoshi Osawa. Cancer metabolism within tumor microenvironments. Biochimica et biophysica acta. General subjects. 2023. 1867. 5. 130330-130330

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MISC (37)：

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Education (3)：

Professional career (1)：

Work history (6)：

2023/04 - 現在 The University of Tokyo Division of Nutriomics and Oncology, RCAST Associate Professor
2018/03 - 2023/03 The University of Tokyo Research Center for Advanced Science and Technology
2011/04 - 2018/02 The University of Tokyo Research Center for Advanced Science and Technology
2007/04 - 2011/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
2007/04 - 2007/12 The University of Tokyo The Institute of Medical Science

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Awards (11)：

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Association Membership(s) (3)：

The Molecular Biology Society of Japan , The Japanese Vascular Biology and Medicine Organization , Japanese Cancer Association

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