Chengzhu Zhao

チョウセイシュ | Chengzhu Zhao

Affiliation and department：

Research field (5)： Pharmacology , Human pathology , Cell biology , Molecular biochemistry , Clinical pharmacy

Research keywords (6)： cell therapy , disease modeling , mesenchymal stem cell , osteogenesis imperfecta , fibrodysplasia ossificans progressiva , human induced pluripotent stem cell

Research theme for competitive and other funds (4)：

2020 - 2023 新規腱靭帯再生医療に向けた高機能靭帯節細胞誘導法の開発
2021 - 2022 ACVR1変異によるFOP細胞増殖亢進の原因分子の同定と解析
2019 - 2021 TGF-βシグナルに反応するFOPフレア・アップ期のメカニズム解明及び候補薬探索
2017 - 2019 FOP病態初期線維性細胞増殖機構の解明及び治療候補化合物の評価

Papers (12)：

Taiki Nakajima, Akihiro Nakahata, Naoki Yamada, Keiko Yoshizawa, Tomoaki M Kato, Mio Iwasaki, Chengzhu Zhao, Hiroshi Kuroki, Makoto Ikeya. Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Nature communications. 2021. 12. 1. 5012-5012
Masayoshi Yoshimatsu, Hiroe Ohnishi, Chengzhu Zhao, Yasuyuki Hayashi, Fumihiko Kuwata, Shinji Kaba, Hideaki Okuyama, Yoshitaka Kawai, Nao Hiwatashi, Yo Kishimoto, et al. In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells. Stem cell research. 2021. 52. 102233-102233
Sadaki Mitsuzawa, Chengzhu Zhao, Ryosuke Ikeguchi, Tomoki Aoyama, Daisuke Kamiya, Maki Ando, Hisataka Takeuchi, Shizuka Akieda, Koichi Nakayama, Shuichi Matsuda, et al. Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific reports. 2020. 10. 1. 12034-12034
Sadaki Mitsuzawa, Ryosuke Ikeguchi, Tomoki Aoyama, Maki Ando, Hisataka Takeuchi, Hirofumi Yurie, Hiroki Oda, Takashi Noguchi, Souichi Ohta, Chengzhu Zhao, et al. Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model. Microsurgery. 2019. 39. 8. 737-747
Kyosuke Hino, Chengzhu Zhao, Kazuhiko Horigome, Megumi Nishio, Yasue Okanishi, Sanae Nagata, Shingo Komura, Yasuhiro Yamada, Junya Toguchida, Akira Ohta, et al. An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva. Stem cell reports. 2018. 11. 5. 1106-1119

ｍore...

MISC (5)：

Naoki Yamada, Chengzhu Zhao, Akira Ito, Tianshu Wang, Akihiro Nakahata, Nan Liang, Taiki Nakajima, Mai Tanaka, Shizuka Akieda, Koichi Nakayama, et al. Peripheral nerve regeneration in a rat crushed sciatic nerve model: Using a Bio 3D sheets generated from human iPSC-derived mesenchymal stromal cells. 2019
Daiju Yamazaki, ChengZhu Zhao, ShengChen Tao, ChaoHong Wang, Miyuki Nishi, Hiroshi Takeshima. Isoproterenol-induced cardiac fibrosis in Tric-a-knockout mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 107P-107P
Chengzhu Zhao, Daiju Yamazaki, Fumiyo Aoyama, Tsunaki Iida, Miyuki Nishi, Akira Sawaguchi, Hiroshi Takeshima. Impaired Bone Formation in TRIC-B-Knockout Mice. BIOPHYSICAL JOURNAL. 2014. 106. 2. 763A-763A
Chengzhu Zhao, Kiho Park, Daisuke Naitou, Chaohong Wang, Daiju Yamazaki, Miyuki Nishi, Jianjie Ma, Hiroshi Takeshima. The Role of Ca2+ Handling in TRIC Knockout Neonatal Cardiomyocytes. BIOPHYSICAL JOURNAL. 2013. 104. 2. 316A-316A
Ki Ho Park, Daiju Yamazaki, Daisuke Naitou, Chengzhu Zhao, Zui Pan, Hiroshi Takeshima, Jianjie Ma. Arrhythmic Intracellular Ca2+ Signaling and Electrocardiogram in the Heart of the TRIC-A(-/-) Mice. BIOPHYSICAL JOURNAL. 2012. 102. 3. 101A-101A

Lectures and oral presentations (1)：

ER counter-ion channel TRIC-B regulates collagen production and bone mineralization
(136th Annual Meeting of the Pharmaceutical Society of Japan 2016)

Education (2)：

2011 - 2016 Kyoto University Graduate School of Pharmaceutical Sciences PhD course
2009 - 2011 Okayama University Graduate School of Pharmaceutical Sciences Master course

Professional career (1)：

PhD (Kyoto University)

Work history (2)：

2016/05 - 現在 Kyoto University Center for iPS Cell Research and Application Program-Specific Researcher
2014/04 - 2016/04 Kyoto University Graduate School of Pharmaceutical Sciences Program-Specific Researcher

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