Art

J-GLOBAL ID：201802223649800775   Reference number：18A2082531

An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva

mTORシグナル伝達調節因子は線維形成性骨化症進行の異所性骨化を抑制する【JST・京大機械翻訳】

Author (17)： Hino Kyosuke (iPS Cell-Based Drug Discovery, Sumitomo Dainippon Pharma Co., Ltd., Osaka 554-0022, Japan) ,  Hino Kyosuke (Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Zhao Chengzhu (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Horigome Kazuhiko (iPS Cell-Based Drug Discovery, Sumitomo Dainippon Pharma Co., Ltd., Osaka 554-0022, Japan) ,  Horigome Kazuhiko (Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Nishio Megumi (Department of Regeneration Sciences and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan) ,  Okanishi Yasue (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Nagata Sanae (Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Komura Shingo (Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan) ,  Komura Shingo (Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Yamada Yasuhiro (Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Toguchida Junya (Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Toguchida Junya (Department of Regeneration Sciences and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan) ,  Toguchida Junya (Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto 606-8507, Japan) ,  Toguchida Junya (Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan) ,  Ohta Akira (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan) ,  Ikeya Makoto (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)
Material： Stem Cell Reports
Volume： 11  Issue： 5  Page： 1106-1119  Publication year： 2018 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Fibrodysplasia ossificans prog...

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Thesaurus term： osteosarcoma ,  receptor ,  osteogenic factor ,  osteogenesis ,  *cellular signal transduction ,  variation(biology) ,  transgenic mouse ,  *heterotopic ossification ,  TGF beta ,  induced pluripotent stem cell ,  *fibrous disease ,  patient
Semi thesaurus term： 軟骨形成 ,  *骨化症 ,  *調節因子 , 【Automatic Indexing@JST】

Author keywords (10)： mammalian target of rapamycin (mTOR) ,  induced pluripotent stem cell (iPSC) ,  fibrodysplasia ossificans progressiva (FOP) ,  endochondral ossification ,  heterotopic ossification ,  bone morphogenetic protein (BMP) ,  transforming growth factor β (TGF-β) ,  activin A ,  high-throughput screening (HTS) ,  ACVR1

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Musculoskeletal diseases  (GG03000T)

Terms in the title (6)： mTOR ,  シグナル伝達 ,  調節因子 ,  線維形成 ,  骨化症 ,  異所性骨化