Rchr

J-GLOBAL ID：201801007844309646 Update date: Jun. 01, 2026

Yokoyama Shigeyuki

Yokoyama Shigeyuki

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (54)：

2024 - 2027 AM-RAMPシステムの全容解明と、生活習慣病・慢性臓器障害への治療応用
2021 - 2024 受容体活性調節システムによる生体内恒常性制御機構の解明と創薬への展開
2018 - 2023 新しい心不全治療薬としての新規PDK4阻害薬の開発
2016 - 2021 Structural analysis of neo-self
2014 - 2017 Building and establishing platform technologies for Structure Based Drug Design targeting AdipoR

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Papers (24)：

Eiko Seki, Tatsuo Yanagisawa, Mitsuo Kuratani, Kensaku Sakamoto, Shigeyuki Yokoyama. Fully Productive Cell-Free Genetic Code Expansion by Structure-Based Engineering of Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase. ACS synthetic biology. 2020. 9. 4. 718-732
Tatsuo Yanagisawa, Mitsuo Kuratani, Eiko Seki, Nobumasa Hino, Kensaku Sakamoto, Shigeyuki Yokoyama. Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell chemical biology. 2019. 26. 7. 936-949
Toru Sengoku, Takehiro Suzuki, Naoshi Dohmae, Chiduru Watanabe, Teruki Honma, Yasushi Hikida, Yoshiki Yamaguchi, Hideyuki Takahashi, Shigeyuki Yokoyama, Tatsuo Yanagisawa. Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP article. Nature Chemical Biology. 2018. 14. 4. 368-374
Eiko Seki, Tatsuo Yanagisawa, Shigeyuki Yokoyama. Cell-free protein synthesis for multiple site-specific incorporation of noncanonical amino acids using cell extracts from RF-1 deletion E. coli strains. Methods in Molecular Biology. 2018. 1728. 49-65
Masatoshi Wakamori, Yoshifumi Fujii, Noriyuki Suka, Mikako Shirouzu, Kensaku Sakamoto, Takashi Umehara, Shigeyuki Yokoyama. Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation. SCIENTIFIC REPORTS. 2015. 5

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