Tanaka Toshiaki

• 2022 - 2025 DNA修復時の「足場」として働く核膜でのリン脂質代謝の機能
• 2018 - 2021 開口分泌小胞形成過程における脂質二重膜の生理機能とその破綻による病態の解明
• 2017 - 2020 脂質代謝酵素ファミリーが織りなす生命現象と疾病:細胞応答から個体レベルの解析
• 2018 - 2020 脂質代謝酵素ファミリーが織りなす生命現象と疾病:細胞応答から個体レベルの解析
• 2012 - 2016 Functional roles of the lipid second messenger metabolizing enzyme family
2008 - 2011 Functional role of lipid second messenger metabolizing enzyme in cell cycle and stress response

• Keiko Seino, Tomoyuki Nakano, Toshiaki Tanaka, Yasukazu Hozumi, Matthew K Topham, Kaoru Goto, Ken Iseki. Ablation of DGKα facilitates α-smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4 -induced hepatic injury. FEBS open bio. 2024. 14. 2. 300-308
• Tomoyuki Nakano, Toshiaki Tanaka, Fumio Sakane, Mika K Kaneko, Yukinari Kato, Kaoru Goto. Immunocytochemical Analysis of DGKη in Cultured Cells Using a Monoclonal Antibody DhMab-4. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2021. 40. 6. 261-265
• Toshiaki Tanaka, Tomoyuki Nakano, Yasukazu Hozumi, Alberto M. Martelli, Kaoru Goto. Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2021. 1868. 4. 118953-118953
• Akimoto R, Tanaka T, Nakano T, Hozumi Y, Kawamae K, Goto K. DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia. Cellular Signaling. 2020. In press. In press. In press-In press
• Tanaka T, Hozumi Y, Martelli AM, Iino M, Goto K. Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate. BBA Molecular Cell Research. 2019

ｍore...

• 田中 俊昭, 岡田 雅司, 後藤 薫. DGKζ結合タンパクNAPはDGKζを細胞質へ移行させ細胞死を抑制する. 解剖学雑誌. 2012. 87. 1. 3-3
• 田中 俊昭, 岡田 雅司, 後藤 薫. 細胞質局在型ジアシルグリセロールキナーゼζはp53の発現を抑制する. 解剖学雑誌. 2009. 84. Suppl. 190-190

• ヒト骨肉腫由来細胞U2OSにおけるp38MAPK、MK2、HSP27リン酸化を介した細胞運動とアポトーシスは、Sec6によって調節される
  (Journal of Oral Biosciences Supplement 2018)

• 2011/04 - 現在 Yamagata University Faculty of Medicine School of Medicine Department of Anatomy and Cell Biology Assistant Professor
• 2010/04 - 2011/03 Yamagata University Faculty of Medicine School of Medicine Department of Dentistry, Oral and Maxillofacial Surgery Assistant Professor

• 2011/04 - NPO法人日本口腔科学会 学会賞優秀発表賞
• 2011/04 - NPO法人 日本口腔科学会 学会賞優秀発表賞受賞

分子生物学会 ,  障害者歯科学会 ,  有病者歯科医療学会 ,  日本抗加齢医学会 ,  THE JAPANESE SOCIETY FOR DISABILITY AND ORAL HEALTH ,  JAPANESE SOCIETY OF DENTISTRY FOR MEDICALLY COMPROMISED PATIENT ,  JAPANESE STOMATOLOGICAL SOCIETY ,  JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  JAPANESE ASSOCIATION FOR ORAL BIOLOGY ,  THE JAPANESE ASSOCIATION OF ANATOMISTS